Clinical trials: Airway Trauma
Respiratory Insufficiency of Prematurity
Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study)
Despite widely used of nasal CPAP in preterm infants, uncertainties regarding aspects of its application remain. Clinical indications vary greatly between institutions, especially when combined with varieties of systems, devices…
- Trial name
- L-CPAP (NCT00636324)
- Testing
- Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome
The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study
The dearth of Intensive care units in low resource settings portends for poor outcomes amongst patients with acute hypoxemic respiratory failure (AHRF) .
- Conditions
- Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- ARISE-AFRICA (NCT04693403)
- Testing
- HFNC, CPAP, Standard Oxygen
- Where
- 17 sites in Uganda
- Volunteers
- 705 people
- Sponsor
- Makerere University
Acute Lung Injury
Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial
The main hypothesis are: 1. Passive and Active-Passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2.
- Trial name
- AirconVAP (NCT01150864)
- Testing
- Airway Conditioning
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Università degli Studi dell'Insubria
Overjet, Dental
Sleep, Upper Airway and Dental Occlusion in Children With Large Overjet
This project examines sleep (e.g. prevalence of obstructive sleep apnea(OSA)), dimension of upper airway, jaw function, well-being and quality of life in children with large overjet compared to a control group.
- Trial name
- NCT04964830
- Testing
- Orthodontic treatment with functional appliance (MAD)
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Post Traumatic Stress Disorder, Anxiety
The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.
We hypothesize that prevention of Sleep Disordered Breathing among PTSD patients with nasal CPAP will result improve their anxiety, insomnia and alcohol craving (among those who use alcohol to control their symptoms).
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Nightmares, Unrefreshed Sleep
- Trial name
- PTSD (NCT01512771)
- Testing
- CPAP
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Northport Veterans Affairs Medical Center
ARDS (Acute Respiratory Distress Syndrome)
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS.
- Trial name
- NCT06790875
- Testing
- Airway Pressure Release Ventilation (APRV)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Cancer
Phase II Evaluation of Exhaled Nitric Oxide (NO)
The goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.
- Trial name
- NCT01392144
- Testing
- Nitric oxide breath test, Questionnaires
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Tracheostomy Decannulation, Acquired Brain Injury
Comparison of the Decannulation Protocol With Suctioning and Capping in Severe Acquired Brain Injury Patients
Single-center randomized trail focused on tracheostomized patients with severe acquired brain injury , comparing two different decannulation protocols: 1.
- Trial name
- NCT04835272
- Testing
- the Decannulation Protocol With Suctioning
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Pulmonary Disease
Mesenchymal Stem Cells Therapy for Treatment of Airway Remodeling in Mustard Patients
Background: Sulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung tissue. SM exposure leads to serious changes in morphological structure of airway system, which is associated with chronic…
- Trial name
- NCT02749448
- Testing
- mesenchymal stem cell
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dr. Mostafa Ghanei
Lung Diseases, Obstructive, Sarcoidosis
Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")
The purpose of this study is to evaluate the safety, effectiveness, and side effects of the CryoSpray AblationTM System (CryoSpray AblationTM, "CSA" or "cryospray therapy") to treat benign airway disease in the lung using liquid…
- Conditions
- Lung Diseases, Obstructive, Sarcoidosis, Wegener's Granulomatosis, Rhinoscleroma
- Trial name
- ICEtheBAD (NCT00747461)
- Testing
- CryoSpray Ablation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- CSA Medical, Inc.
Trauma Injury, Airway Control
LITES Task Order 0005 Prehospital Airway Control Trial (PACT)
The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients.
- Trial name
- PACT (NCT04100564)
- Testing
- Supraglottic airway device, Standard airway management
- Where
- 14 sites in United States
- Volunteers
- 2,010 people
- Sponsor
- Jason Sperry
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
NCPAP + Heliox as a Treatment for Infant Respiratory Distress Syndrome (RDS)
Infants born between 28 and 32 weeks' gestation with radiological findings and clinical symptoms of moderate RDS, requiring respiratory support with Nasal Continuous Positive Airway Pressure (NCPAP) within the first hour of life…
- Trial name
- NCT01383850
- Testing
- NCPAP + standard air, NCPAP + Heliox
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bronchopulmonary Dysplasia, Nasal High-frequency Oscillatory Ventilation
Nasal High-frequency Oscillatory Ventilation (NHFOV) for Ventilated Newborn Infants With BPD
Invasive ventilation(IV) remains one key cornerstone to reduce neonatal mortality for preterm infants with respiratory distress syndrome(RDS) and/or acute respiratory distress syndrome(ARDS).
- Conditions
- Bronchopulmonary Dysplasia, Nasal High-frequency Oscillatory Ventilation, Nasal Continuous Positive Airway Pressure, Neonate
- Trial name
- NCT04905732
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Injury Throat
Nasopharyngeal Versus Laryngeal Mask Airway in Anaesthesia for Bilateral Blepharoplasty
General anaesthesia demands securing patient's airway either with endotracheal tube or laryngeal mask (LMA); however, both carry the disadvantage of postoperative soar throat.
- Trial name
- NCT03510949
- Testing
- Nasopharyngeal airway or laryngeal mask airway
- Where
- Egypt
- Volunteers
- 148 people
- Sponsor
- Hala Salah El-Din El-Ozairy
Lung Cancer, Pleural Cancer
Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer
This study has been designed to utilize already obtained biopsy specimens for investigation of the utility of a new, non-invasive optical diagnostic technique.
- Conditions
- Lung Cancer, Pleural Cancer, Prostate Cancer
- Trial name
- NCT00581503
- Testing
- diagnostic
- Where
- 2 sites in United States
- Sponsor
- University of California, Irvine
ARDS: Acute Respiratory Distress Syndrome, ARDS
Compare Between APRV and Bipap Ventilation in ARDS Patients
To evaluate whether early use of airway pressure release ventilation would improve oxgyenation , improve lung compliance and shorten the time of mechanical ventilation compared to BIPAP ventilation in ARDS patients
- Trial name
- NCT06755320
- Testing
- mechanical ventilation (MV)
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Newborn, Pressure Injury
Pressure Injuries' Prevention in Newborn Infants Admitted to NICU
Nasal Continuous Positive Airway Pressure (NCPAP) is a respiratory support for neonates with Respiratory Distress Syndrome (RDS) and represents the gold standard for RDS treatment in many Neonatal Intensive Care Units (NICU).
- Trial name
- NCT04293601
- Testing
- interventional nursing care, Standard nursing care
- Where
- Italy
- Volunteers
- 280 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Airway Obstruction
Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture
The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of malignant central airway stricture.
- Trial name
- NCT02299830
- Testing
- cryotherapy, argon plasma coagulation, stent placement
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital