Clinical trials: Airway Trauma
Acute Pain, Multiple Trauma
Ketamine Patient-Controlled Analgesia for Acute Pain
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have…
- Conditions
- Acute Pain, Multiple Trauma, Fractures
- Trial name
- NCT02062879
- Testing
- Ketamine, Hydromorphone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Difficult Intubation, Cervical Injury Spine
Macintosh and D-Blade® in Simulated Difficult Airway
In the presented study, our aim was to compare intubation conditions regarding the modified Cormack \& Lehane score (CL) between the D-Blade® in indirect laryngoscopy or Macintosh blade in direct and indirect laryngoscopy with…
- Trial name
- NCT03403946
- Testing
- Macintosh blade, D-Blade, Intubation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Respiratory Insufficiency, Ventilator-Induced Lung Injury
APRV/BIPAP With Spontaneous Breathing on Lung Protection
Mechanical ventilation (MV) is a cornerstone of management of acute respiratory failure, but MV per se can provoke ventilator-induced lung injury (VILI), especially in acute respiratory distress syndrome (ARDS).
- Trial name
- APRV/BIPAP (NCT02071277)
- Testing
- Pressure targeted modes
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Chronic Cough
Remodelling of the Lower Airways in Chronic Cough
The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month .
- Trial name
- NCT07659860
- Testing
- chest computed tomography and bronchoscopy
- Where
- 4 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
Acute Brain Injury, Post-neurosurgical Status
High-Flow Nasal Cannula After Extubation in Acute Brain Injury
Patients with acute brain injury after neurosurgery are at increased risk of extubation failure after removal of the endotracheal tube.
- Conditions
- Acute Brain Injury, Post-neurosurgical Status, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07664085
- Where
- Vietnam
- Volunteers
- 285 people
- Sponsor
- Bach Mai Hospital
Trauma, Wounds and Injuries
Registry of Emergency Airways Arriving at Combat Hospitals
This represents the first prospective examination of advanced airway management under combat conditions. The findings will have a tremendous impact on both modern prehospital medical practice and on the treatment of our wounded…
- Conditions
- Trauma, Wounds and Injuries, Emergencies
- Trial name
- REACH (NCT01405001)
- Volunteers
- 292 people
- Sponsor
- William Beaumont Army Medical Center
Sleep Apnea, Obstructive, Hypoxia
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
The purpose of this study is to determine the factors that are associated with improved cardiovascular function with the use of CPAP therapy on subjects diagnosed with moderate to severe obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypoxia, Hypercapnia, Sleep Disorders
- Trial name
- NCT01317329
- Testing
- Clinically prescribed CPAP therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Out-Of-Hospital Cardiac Arrest, Trauma
AI to Improve Data From Danish Cardiac Arrest Registry
Out-of-hospital cardiac arrest is a leading cause of death worldwide and patient outcome vary substantially throughout regions suggesting further evaluation and potential for improvement.When focussing on subgroups of OHCA, data…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Trauma, Drug Overdose, Electrocution
- Trial name
- NCT05308303
- Where
- Denmark
- Volunteers
- 31,200 people
- Sponsor
- Prehospital Center, Region Zealand
Acute Respiratory Distress Syndrome
Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode.
- Trial name
- NCT04221737
- Testing
- APRV. General Electric Healthcare Engstrom ventilator system, Conventional. General Electric Healthcare Engstrom ventilator system
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Hospital Civil de Guadalajara
ARDS (Acute Respiratory Distress Syndrome)
Comparative Study Between Airway Pressure Release Ventilation and Pressure Regulated Volume Control (PRVC) in Protective Lung Strategy as a Recruitment Maneuver for Severe ARDS Mechanically Ventilated Patients Using Lung Ultrasound Score
The aim of this study is to elaborate on the effectiveness of recruitment maneuver by airway pressure release ventilation (APRV) as an open lung ventilatory strategy in comparison with PRVC mode in lung protective strategy…
- Trial name
- NCT07231107
- Testing
- Lung ultrasound
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Spinal Injuries
Comparison by Neuromonitoring of Two Techniques of Tracheal Intubation in Patients With Unstable Cervical Spine
Patients who present with an unstable cervical spine following an accident need a general anesthesia for the necessary surgery. Commonly, the management of the tracheal intubation is performed by a fiberoptic technique.
- Trial name
- NCT02382887
- Testing
- tracheal intubation, Airtraq, fiberscope
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Lausanne Hospitals
Acute Respiratory Failure, Mechanical Ventilation Complication
Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated Patients
Mechanical ventilation may be associated with ventilator-induced lung injury (VILI). Several respiratory variables have been employed to estimate the risk of VILI, such as tidal volumes, plateau pressure, driving pressure, and…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- P1P2Decay (NCT05991258)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Padova
Acute Lung Injury, Adult Respiratory Distress Syndrome
Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI)
Healthy biological systems are characterized by a normal range of "variability" in organ function. For example, many studies of heart rate clearly document that loss of the normal level of intrinsic, beat-to-beat variability in…
- Trial name
- NCT01083355
- Where
- United States
- Sponsor
- Boston Medical Center
Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia
Seattle-PAP Bubble Nasal CPAP and Work of Breathing
The investigators propose to test the hypothesis that Seattle bubble nasal continuous positive airway pressure (Seattle-PAP) supports respiratory physiology in very low birth weight (VLBW) infants more effectively than standard…
- Conditions
- Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia, Newborn Primary Sleep Apnea
- Trial name
- Seattle-PAP (NCT02210026)
- Testing
- Seattle-PAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore