Clinical trials: Alcohol Addiction
Alcohol Abuse
Genetic and Neural Factors in Alcohol-Related Cognition
This study examines the genetic factors that impact cognitive processes and behavior after alcohol consumption. Participation in this project will contribute to a better understanding of cognitive factors that influence alcohol…
- Trial name
- NCT03725345
- Testing
- MRI Scanner
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Alcohol Use Disorder (AUD), Schizophrenia and Related Disorders
Dynamics of Risk Perception and Risk Behavior in Alcohol Use Disorder and Schizophrenia
The hyper- or hypo-attribution of risks is deeply related to the core pathological mechanisms of mental disorders and at the same time engaging in risky behaviors influences their course and outcomes.
- Trial name
- PathRisk (NCT04985786)
- Testing
- Cognitive Behavioral Therapy for reducing risk behaviors, Cognitive Behavioral Therapy for increasing non-risk behaviors
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Alcohol Use Disorder
Automated Reinforcement Management Systems, Phase II
The Automated Reinforcement Management Systems Phase II (ARMS II) study is a phase II trial is a randomized controlled, non-medicated assisted trial to determine the effectiveness of Contingency Management (CM) treatment for…
- Trial name
- ARMS II (NCT06456905)
- Testing
- Contingency Management
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington State University
Alcohol Use Disorder
Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study
Study to enroll up to 90 individuals, those with an alcohol use disorder (AUD) (up to n=60) and non-dependent healthy volunteers (HV) (up to n=30).
- Trial name
- AUD (NCT05885594)
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
fMRI, Alcohol Drinking
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers
Background: Ghrelin is a hormone in the human body that is mostly produced by the stomach. It makes people feel hungry, and also is connected with the desire to drink alcohol.
- Conditions
- fMRI, Alcohol Drinking, Alcoholism
- Trial name
- NCT01779024
- Testing
- Ghrelin, fMRI, Alcohol
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorders
Randomized Trial of Intensive Motivational Interviewing (IMI) to Improve Drinking Outcomes Among Women
A Phase II Randomized Clinical Trial (RCT) is proposed to compare a 9-session model of intensive motivational interviewing (IMI) to standard motivational interviewing techniques (SMI) among alcohol dependent women.
- Trial name
- NCT02272023
- Testing
- Intensive Motivational Interviewing, Single session of Motivational Interviewing
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Public Health Institute, California
Hepatitis C, Transmission, Intravenous Drug Abuser
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose…
- Conditions
- Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate
- Trial name
- SCANVIR (NCT05361603)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Alcohol Abuse, Impulsive Behavior
Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users
The purpose of this study is to determine the effects of tolcapone on decision making and alcohol intake using a laboratory bar (on-site alcohol self-administration) in alcohol drinkers.
- Trial name
- NCT02740582
- Testing
- Tolcapone
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Jennifer Mitchell
Alcohol Use Disorder, Drug Use
A Hybrid Effectiveness Implementation Study of Latino/a Alcohol and Drug Users
Alcohol use is a significant problem among Latinxs and immigration-related stress increases risk for substance use. A theoretically-based cultural adaptation of motivational interviewing (CAMI) that specifically integrated…
- Conditions
- Alcohol Use Disorder, Drug Use, Psychological Distress
- Trial name
- CAMI-HI (NCT04771650)
- Testing
- CAMI
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alcoholism
The Effects of Levetiracetam on Alcohol Dependent Subjects
This study will attempt to examine whether Levetiracetam (Keppra (TM)) can help people with alcohol dependence cut down on their alcohol consumption.
- Trial name
- NCT00325182
- Testing
- Levetiracetam, Historical controls
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcohol Use Disorder, Trauma, Psychological
Adverse Childhood Experiences in Substance-related Disorders
Aversive childhood experiences (ACE) and their relation to the development of an alcohol use disorder will be measured with fMRI.
- Trial name
- NCT03758053
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Use Disorder
Citicoline in Youth Alcohol Use Disorder
The goal of this study is to evaluate how citicoline, an over-the-counter supplement, versus a placebo pill (i.e., an inactive pill) affects the immune system, brain, and cognition in adolescents who may use alcohol.
- Trial name
- NCT05870111
- Testing
- Citicoline (cytidine diphosphate-choline)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cardiovascular Disease, Alcohol Use Disorder
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
The purpose of this research study is to investigate if a personalized intervention including parts such as navigation (focus on patient outreach efforts, missed and completed encounters), personalization (individual health…
- Conditions
- Cardiovascular Disease, Alcohol Use Disorder, HIV Risk, Substance Use Disorders
- Trial name
- NCT05828849
- Testing
- Navigation, compensation, and personalization
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alcohol, Alcohol Use Disorders
A Phase I Study of the Interaction of Alcohol With Oral AFA-281 in Healthy Volunteers
The goal of this clinical trial is to evaluate if alcohol interacts with the drug candidate AFA-281 in adults (healthy volunteers). This trial will evaluate blood concentration levels of AFA-281 and ethanol.
- Trial name
- NCT06719908
- Testing
- AFA-281 is a small molecule, orally available, Alcohol (Ethanol)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Alcohol Abuse
Family Based Contingency Management for Adolescent Alcohol Abuse
The goal is to adapt the family-based CM treatment to target primary adolescent alcohol abuse and dependence. Specific Aim 1 is to provide a preliminary demonstration of the efficacy of a family-based CM intervention to treat…
- Trial name
- NCT00595478
- Testing
- Motivational Enhancement Therapy (MET)/CBT+CM, Motivational Enhancement Therapy (MET)/CBT
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Borderline Personality Disorder, Alcohol Use Disorder
Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder
The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.
- Trial name
- NCT00145678
- Testing
- Psychodynamic Therapy, Optimized Community Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alcoholism
Cognitive Vulnerability Factors in Alcohol-dependence
The purpose of this study is to specify the cognitive and genetic pattern associated with alcohol dependence. Results will help identifying more precisely vulnerability factors associated with this disorder.
- Trial name
- CoVAD (NCT02842528)
- Testing
- Diagnostic Interview for Genetic Studies, Family Informant Schedule and Criteria, Temperament and Character Inventory
- Where
- France
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell.
- Trial name
- NCT05677321
- Where
- United States
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Drinking, Alcohol Abuse
A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women
Sexual minority women in the United States are more likely to drink alcohol, engage in heavy drinking, and experience alcohol-related problems than are heterosexual women.
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
- Trial name
- NCT03884478
- Testing
- Personalized Normative Feedback
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University