Clinical trials: Alcohol Addiction
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention to Reduce Alcohol Use in Malawi
With a full-scale randomized control trial, the investigators will evaluate the efficacy and cost effectiveness of Mlambe, an economic and relationship-strengthening intervention that provides incentivized saving accounts…
- Trial name
- NCT06367348
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Drinking, Alcohol Use Disorder
Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study
In this study, the investigators aim to capture inter- and intra-brain mechanisms underlying alcohol reward in novel social context.
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT06687525
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcoholism
Health Focused Motivational Treatment for Alcohol Dependent Veterans
The purpose of this study is to determine whether a health focused motivational intervention will reduce alcohol use for dependent veterans who are receiving outpatient alcohol and drug treatment.
- Trial name
- NCT00252590
- Testing
- Health Motivational Feedback, Health Education, Control - treatment as usual
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcoholism
Neural Mechanisms Underlying Alcohol Induced Disinhibition
Forty 18-year-old social drinkers will be selected from the sample tested in specific aim 1 ("Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)"…
- Trial name
- NCT01097213
- Testing
- Ethanol
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Alcohol Abuse, Obesity
Project ACTIVE a Clinical Intervention
This is a clinical Randomized Controlled Trial where the study personnel will run a personalized prevention clinic with patients in attempts to improve their preventive health outcomes and compare their health outcomes with a…
- Trial name
- NCT04211883
- Testing
- ACTIVE intervention
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Drinking, Alcohol Use Disorder
Ketone Ester Intervention in Alcohol Use Disorder
The purpose of this research is to study how a nutritional ketone ester may effect brain function and alcohol consumption in regular alcohol users.
- Trial name
- NCT04616781
- Testing
- Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Alcohol drinks
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Addictive Behavior, Alcohol Use Disorder
90-Day Online Substance Use Program
Individuals indicating risky substance use are randomly assigned either to a three-month online intervention on the Workit Health platform or a waitlist/treatment as usual.
- Conditions
- Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse
- Trial name
- NCT03069118
- Testing
- Treatment - Workit Health Online Program, Control - Resource List
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Workit Health
Alcoholism, Depression
Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism.
The aim of the present study was to examine the influence of memantine, a noncompetitive NMDA receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor, escitalopram.
- Trial name
- NCT00368862
- Testing
- Ebixa (memantine hydrochloride), Cipralex (escitalopram)
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
HIV/AIDS, Alcohol Abuse
Couple-Based Motivational Interviewing With Mobile Breathalyzers to Reduce Alcohol Use in South Africa
This project aims to develop and pilot test an intervention using couple-based motivational interviewing (MI) and mobile breathalyzers to reduce heavy alcohol use with couples living with HIV in South Africa.
- Trial name
- NCT05756790
- Testing
- Motivational Interviewing, Motivational Interviewing plus Breathalyzer
- Where
- South Africa
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Cardiovascular Diseases, Obesity Prevention
Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial
Background: Chronic diseases, such as cardiovascular diseases, diabetes, and cancer, are a major global health issue. Their modifiable risk factors, including poor diet, physical inactivity, irregular sleep, tobacco use, and…
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Sedentary Behaviors, Sleep Perception
- Trial name
- NCT06894134
- Testing
- Team-based learning
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Alcoholism, Healthy
Serotonin in Alcoholism
This study uses positron emission tomography (PET) scanning to study how serotonin works in alcoholics. Serotonin is a chemical that allows brain cells to communicate.
- Trial name
- NCT00011752
- Testing
- FCWAY
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholism
Alcohol Addiction: A Systems-oriented Approach
The goal of the multicenter subproject (SP) 10 of the eMED Alcohol Addiction Consortium - A Systems-Oriented Approach is to study neuroimaging x genetics predictions in an existing sample (NGFNplus) of tightly endophenotyped and…
- Trial name
- eMedAlcohol (NCT02910193)
- Where
- Germany
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alcohol Abuse
Brief Intervention for Families of Teens Treated in the Emergency Department for an Alcohol-Related Event
The purpose of this study is to compare the effectiveness of a brief family intervention in reducing alcohol use and alcohol-related problems among families of underage drinkers (13-17 years old) who are treated in a hospital…
- Trial name
- NCT00247221
- Testing
- MI/Family Check-up, MI only
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder (AUD)
Measuring Beliefs and Norms About Persons With Alcohol Use Disorder
Survey experiment to estimate drivers of stigma toward people with alcohol use disorder
- Trial name
- NCT04832321
- Testing
- Survey questionnaire
- Where
- Uganda
- Volunteers
- 1,363 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Alcoholism
In this study, eligible alcoholic inpatients recruited from a specialized clinic for addiction treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions…
- Trial name
- tDCS_ALCOHOL (NCT02091284)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Unhealthy Alcohol Use, Alcohol Use Disorder
Relational Agent for Alcohol Screening and Treatment
This project will involve the development and initial evaluation of a promising computer-based intervention to improve the primary care management of risky alcohol use among Veterans.
- Conditions
- Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
- Trial name
- RAAST (NCT02030288)
- Testing
- Relational Agent Intervention
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development