Clinical trials: Alcohol Addiction
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse
Optimisation of Functional MRI-based Neurofeedback for Alcohol Use Disorders
Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour).
- Trial name
- NCT02406456
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Alcohol Dependence
A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects
The safety, tolerability, and pharmacokinetics of nalmefene at a single oral dose of 10 mg in healthy Japanese male subjects will be evaluated.
- Trial name
- NCT02679469
- Testing
- nalmefene hydrochloride 10 mg
- Where
- Japan
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Mental Health
An Evaluation of Innerview™, a Web-based Tool to Support the Integration of Mental Health in the Primary Care Setting
Innerview can address some of the challenges of integrating mental health and primary care by accurately and reliably collecting mental health evidence and activities directly from patients, and then organizing and automating…
- Trial name
- NCT02025647
- Where
- 5 sites in United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Pearson/Clinical Assessment
Obesity, Alcohol Dependence
Norepinephrine Transporter Imaging in Addiction Disorders
In this study we propose to study 24 unmedicated abstinent alcohol dependent patients, 24 obese individuals and 24 individually matched healthy control subjects and determine Norepinephrine Transporter (NET) expression in vivo…
- Trial name
- NCT01719458
- Testing
- (S,S)-[11C]MRB
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Alcoholism
The Tolerability and Effects of AZD0530 in Individuals With or Without a Family History of Alcoholism
Functional neuroimaging of alcoholism vulnerability: glutamate, reward, impulsivity, and Pavlovian-to-instrumental transfer (PIT), part II Saracatinib
- Trial name
- NCT02262026
- Testing
- 125 mg AZD0530, 50 mg AZD0530
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol; Harmful Use
Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults
This study will: (1) refine and finalize the SPEAR intervention manual for preventing alcohol use disorders (AUD) and associated harms for Pacific Islander young adults; and (2) test SPEAR for efficacy by conducting a…
- Trial name
- NCT06337721
- Testing
- SPEAR (Strategies for Pacific Empowerment and Alcohol Reduction)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Bipolar Disorder, Alcohol Dependence
Optimizing Pharmacotherapy for Bipolar Alcoholics
The purpose of this study is to test the efficacy of naltrexone and valproate in the treatment of comorbid bipolar disorder and alcohol dependence.
- Trial name
- NCT00302133
- Testing
- Naltrexone hydrochloride
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Miami
Healthy Controls, Alcohol Use Disorder
Deciphering the Role of Oxytocin in Motivation: an fMRI Study. Part II
The proposed study will investigate the effects of intranasal oxytocin administration on neural activity associated with social and non-social motivation.
- Trial name
- NCT02652195
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Utah
Alcohol-induced Cue-craving, Alcohol Sensitivity
A Gene by Medication Interaction to the Acute Effects of Alcohol
Alcohol dependence, or "alcoholism", affects approximately 14 million Americans. Currently, only three pharmacotherapies (disulfiram, naltrexone, and acamprosate) have been approved for the treatment of alcohol dependence and…
- Trial name
- ATX (NCT01343628)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol Use Disorder
The Efficacy of Probiotics for the Treatment of Alcohol Use Disorder Among Adult Males
This two-armed, parallel-group, double-blind, multi-center randomized control trial (RCT) aims to evaluate the efficacy of probiotic supplement compared with placebo in ameliorating alcohol craving and severity of alcohol use…
- Trial name
- NCT05830708
- Testing
- Lactobacillus sp. probiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Well Being, Drug Addiction
Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST )
Life Skills Training is a school-based prevention program aiming at promoting wellbeing and at preventig use of substances. It has a version for middle school and another for primary school students.
- Conditions
- Well Being, Drug Addiction, Tobacco Use, Alcohol Abuse
- Trial name
- Val3P-LST (NCT07858513)
- Testing
- life skills primary prevention
- Where
- Italy
- Volunteers
- 3,927 people, healthy volunteers welcome
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Alcohol Use Disorder, Inflammatory Response
Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use
The study design consists of a randomized, double-blind, placebo-controlled study of low dose endotoxin. Individuals with current AUD (n=32) and matched controls without AUD (n=32) will be randomly assigned to receive a single…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving
- Trial name
- NCT07452146
- Testing
- Endotoxin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Abuse, Peripheral Neuropathy
Cutaneous Denervation in Alcoholic Neuropathy
Peripheral neuropathy is a frequent neurological complication of chronic alcoholism. Most studies evaluated large-fiber involvement by nerve conduction studies (NCS).
- Trial name
- NCT00190073
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Alcohol Use Disorder
Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients
Background: Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse.
- Trial name
- REAL (NCT02881983)
- Testing
- the presentation of pictures (static stimuli) or videos (dynamic stimuli)
- Where
- 2 sites in France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alcohol Abuse or Dependence
FGF21 and Its Role in Alcohol Dependence
Plasma fibroblast growthfactor-21 (FGF21) responses to acute alcohol exposure will be evaluated in three groups: A: 15 individuals diagnosed with alcohol dependence (ICD10 code F10.2) and no alcoholic liver diseases, B: 15…
- Trial name
- AlcoDep (NCT03892369)
- Testing
- Ethanol
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Alcohol Abuse
Impact of a Brief Motivational Interview on Drinking Behaviors of At Risk Drinkers Screened in the Emergency Room
Alcohol abuse is associated with injury, chronic illness, absenteeism from work, and social costs to families and communities. The goal of this project is to translate motivational interventions successful in the primary care…
- Trial name
- NCT00183183
- Testing
- Screening and Brief Intervention
- Where
- 15 sites in United States
- Volunteers
- 1,137 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol; Use, Problem
Probiotics, Immune Function, and the Brain in Alcohol Consumers
This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no…
- Trial name
- NCT05232682
- Testing
- Seed DS-01 Daily Synbiotic
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder
Testing the Efficacy of an Online Integrated Treatment for Comorbid Alcohol Misuse and Emotional Problems
Considering the high comorbidity between alcohol use disorders and emotional problems, there is currently a need for accessible, integrated treatments designed to target both disorders simultaneously.
- Trial name
- NCT03406039
- Testing
- Integrated Online CBT and MI
- Where
- Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Alcohol Related Disorders, Alcoholism
Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects
To monitor the inhibition of 5a-reductase (5AR) enzyme activity at 1, 3, 7, 14, 21, 28 and 42 days following administration of a single dose of dutasteride (2, 3, or 4 mg) by measuring the change in blood levels of…
- Conditions
- Alcohol Related Disorders, Alcoholism, Alcohol Abuse
- Trial name
- NCT00802321
- Testing
- Dutasteride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UConn Health