Clinical trials: Alcohol Addiction
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder (AUD)
Study of DCR-AUD in Healthy Volunteers
DCR-AUD will be evaluated for safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
- Trial name
- NCT05021640
- Testing
- DCR-AUD
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Mental Disorder, Depressive Disorder
Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
A growing number of trials have demonstrated treatment effectiveness for mental illness by non-specialist providers, such as primary care providers, in low-resource settings.
- Conditions
- Mental Disorder, Depressive Disorder, Anxiety Disorder, Alcohol Use Disorder
- Trial name
- RESHAPE-cRCT (NCT04282915)
- Testing
- Reducing Stigma among Healthcare Providers (RESHAPE), mental health Gap Action Programme
- Where
- Nepal
- Volunteers
- 8,705 people, healthy volunteers welcome
- Sponsor
- George Washington University
Alcohol Use Disorder
Influence of n-Acetylcysteine Maintenance on Alcohol Effects
This study will evaluate the behavioral effects of alcohol during placebo and n-acetylcysteine maintenance using sophisticated human laboratory methods.
- Trial name
- NCT03216954
- Testing
- Alcohol, N-acetyl cysteine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- William Stoops
Alcohol Addiction, Opiate Addiction
Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction
Hypothesis: Patients who are addicted to opioids or alcohol will have reduced substance use, health care utilization if they have immediate and convenient access to pharmacotherapy and addiction counselling.
- Trial name
- H-SOAP (NCT01934751)
- Testing
- Delayed Intervention (DI), Rapid Intervention (RI)
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Risky Health Behavior, Drinking, Alcohol
STUN (STop UNhealthy) Alcohol Use Now! Implementing Evidence-Based Services for Unhealthy Alcohol Use in Primary Care
STUN Alcohol Use Now is an intervention designed to use primary care practice support services (practice facilitation) to help small to medium-size practices (10 or fewer providers) identify and provide services for people with…
- Conditions
- Risky Health Behavior, Drinking, Alcohol, Alcohol Use Disorder, Drinking, Binge
- Trial name
- STUN (NCT04317989)
- Testing
- Practice Facilitation
- Where
- 7 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Dependence
Fish Oil vs. Placebo on Subjective Effects of Alcohol
This project represents a first step in examining the potential use of fish oil for the treatment of alcohol use disorder (AUD).
- Trial name
- NCT03010917
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Yale University
Stress Disorders, Post-Traumatic, Alcoholism
The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD
This study will investigate the effects of oxytocin on alcohol-related behaviors, social abilities, and physiological startle responses in healthy individuals and patients with posttraumatic stress disorder (PTSD) and alcohol use…
- Trial name
- POP (NCT02469259)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Abuse
Family Intervention for Teen Drinking in the ER
The investigators propose a randomized controlled trial with five aims: 1. To investigate the engagement potential and effectiveness of a family-centered intervention (MDFT) and Family Motivational Interviewing Intervention…
- Trial name
- NCT01229748
- Testing
- Standard Care, Multidimensional Family Therapy, Family Motivational Interviewing Intervention
- Where
- 3 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alcohol Use Disorder
Identification of Cellular and Molecular Mechanisms Involved in the Pathophysiology of Alcohol Use Disorder by Examination of Cerebrospinal Fluid
BACKGROUND The brain and spinal cord are enveloped by cerebrospinal fluid (CSF), which extends down to the base of the spine, a few centimeters below the termination of the spinal cord.
- Trial name
- NCT06286449
- Testing
- Spinal tap
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Depression Disorders, Bipolar Affective Disorder
Epidemiological Study on the Prevalence of Mental Disorders in Slovakia
This study maps the current epidemiological situation of mental disorders in Slovakia. The aim of the study is to determine the prevalence of selected mental disorders in the adult population of the Slovak Republic, assess the…
- Conditions
- Depression Disorders, Bipolar Affective Disorder, Generalized Anxiety Disorder (GAD), Panic Disorder
- Trial name
- EpiMentDisSK (NCT07129408)
- Where
- Slovakia
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Comenius University
Alcohol Dependence
Network Support for Treatment of Alcohol Dependence
Relapse is the most serious problem in alcoholism treatment. The overall aim of the present study was to determine if a treatment directed at changing the patient's social network, from one that reinforces drinking behavior to…
- Trial name
- NCT00845208
- Testing
- Network Support
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- UConn Health
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alcohol Drinking, Alcohol Abuse
Using Counter Attitudinal Advocacy to Change Drinking Behavior
High volume drinking by young adults has proven resistant to change, so new approaches are needed. We adapt a theory-based attitude change strategy for use in alcohol prevention.
- Trial name
- NCT04042909
- Testing
- Counter Attitudinal Advocacy, Personalized Normative Feedback
- Where
- 2 sites in United States
- Volunteers
- 591 people, healthy volunteers welcome
- Sponsor
- Brown University
Schizophrenia, Bipolar Disorder
Individualizing Incentives for Alcohol in the Severely Mentally Ill
The investigators will evaluate the efficacy of a 2 various contingency management (CM) interventions (High-Magnitude CM, Shaping CM) for treating heavy drinking among individuals with serious mental illness and alcohol…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Alcohol Dependence
- Trial name
- NCT03481049
- Testing
- Usual CM, High-Magnitude CM, Shaping CM
- Where
- 2 sites in United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Washington State University
Alcohol Use Disorder
Semantic Networks in Alcohol Use Disorder Patients: Exploratory Study
Alcohol Use Disorder (AUD) is a major public health problem, characterized by a high rate of relapse. Chronic and excessive alcohol consumption notably induces frontal brain alterations and cognitive impairments such as executive…
- Trial name
- ALCOOLNET (NCT05636033)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Smoking Cessation, Alcohol-Related Disorders
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking.
- Trial name
- NCT00304707
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Addiction
Disulfiram as a Modulator of Amyloid Precursor Protein-processing
A causal therapeutic approach for treatment of Alzheimer's disease has not been established so far. The protein ADAM10 represents a promising target for an A-beta peptide preventing strategy.
- Trial name
- DIMAP (NCT03212599)
- Testing
- Disulfiram
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz