Clinical trials: Alcohol Addiction
Implementation Science
Implementation of Two Transdiagnostic Interventions Based on Emotional Regulation (DBT and UP) for Alcohol Addiction
The aim of this study is to evaluate the dissemination and implementation process of two transdiagnostic psychological interventions (Dialectical Behavioral Therapy for Substance Use Disorders-DBT-SUD and Unified Protocol-UP) to…
- Trial name
- NCT06366100
- Testing
- Dialectical Behavior Therapy for Substance Use Disorder (DBT-SUD), Unified Protocol (UP)
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
High Intensity Use of Urgent and Emergency Care, Emergency Medicine
High Intensity Use of Urgent and Emergency Care: A Mixed-Methods Study
This study aims to understand the health and social care needs and experiences of adults who frequently use urgent and emergency care services in Dorset.
- Conditions
- High Intensity Use of Urgent and Emergency Care, Emergency Medicine, Health Inequalities, Mental Health
- Trial name
- NCT07630012
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Alcohol Use Disorder, Cigarette Smoking
Semaglutide for Alcohol Use Disorder
This is an early-Phase II human laboratory trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol…
- Trial name
- NCT05520775
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcoholism
Levetiracetam XR in Very Heavy Drinkers
The primary objectives of this study are to assess the efficacy of levetiracetam XR in increasing the percentage of subjects with no heavy drinking days and in reducing the weekly percentage of heavy drinking days in subjects…
- Trial name
- NCIG 002 (NCT00970814)
- Testing
- BBCET, Levetiracetam XR, Sugar Pill
- Where
- 5 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Obesity, Alcohol Dependence
Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET
The aim of the present study is to conduct a human trial of [C-11]OMAR, a new PET imaging agent for the brain cannabinoid type 1 receptors (CB1), to determine its pharmacokinetics and binding characteristics.
- Conditions
- Obesity, Alcohol Dependence, High Stress
- Trial name
- NCT01719497
- Testing
- [C-11]OMAR
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Dependence, Alcohol Dependence
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
- Conditions
- Opioid Dependence, Alcohol Dependence, Multiple Sclerosis
- Trial name
- NCT05620940
- Testing
- Vivitrol Injectable Product, IVL3004, IVL4002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inventage Lab., Inc.
Alcohol Use Disorder
Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control Subjects
Impulsivity is a central feature of addiction. Nalmefen is an authorized treatment for alcohol addiction. Baclofen has empathically been advocated to have some efficacy in this indication.
- Trial name
- NCT03034408
- Testing
- Nalmefene, Baclofen
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Prof. Daniele Zullino
Alcohol Abuse
Attitudes & College Experiences
High volume drinking by young adults has proven resistant to long term change, so new approaches are needed. Given strong associations between alcohol-related attitudes and drinking behavior, the investigators adapt a…
- Trial name
- ACE (NCT04026633)
- Testing
- CAA, Control
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Brooklyn College of the City University of New York
Healthy, Alcohol Use Disorder (Mild vs. Moderate to Heavy)
Modification of Pavlovian and Instrumental Learning in Human Addiction
The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.
- Trial name
- NCT04032587
- Testing
- Modified training version of the Approach / Avoidance Task (AAT, see Wiers et al., 2011), Mindfulness-based interventions (e.g. body scan)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Abuse, Alcohol Use Disorder
Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
The primary aims of the study are to assess the user experience and initial efficacy of a mobile application designed to reduce problematic alcohol use.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Abuse, Episodic
- Trial name
- ALCMOD (NCT04286867)
- Testing
- Alcohol Moderation Mobile Application, Alcohol Moderation Drink Tracker
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kent State University
Alcohol Use Disorder
Supporting Adolescent Alcohol Treatment With Computer-Based ('Path180') Skills Training
This 8-week clinical trial will test a computer-based skills training program called Path180 with 112 adolescents aged 13 to 19 who are receiving mental health counseling or outpatient substance use treatment.
- Trial name
- NCT07713251
- Testing
- Path180
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder, Depression
Project VALOR: Veteran Stress and Wellbeing
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior veterans as the move into their second year post-Army.
- Trial name
- NCT06095817
- Testing
- Internet Delivered Brief Intervention (IDBI)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cornell University
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Related Disorders, Substance Related Disorders
The Co-Venture Trial: A Cluster Randomized Trial of Personality-targeted Interventions on Adolescent Substance Use and Cognitive Outcomes
The Preventure Program is the first and only school-based alcohol and drug prevention program that has been shown to prevent onset and growth in alcohol and substance misuse in British and Canadian youth.
- Trial name
- NCT01655615
- Testing
- Preventure programme
- Where
- Canada
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Alcohol Use Disorder
NIAAA Natural History Protocol
Background: About 17 million adults had an alcohol use disorder in 2012. Researchers want to follow people that have alcohol problems and want treatment, as well as those who do not want treatment and healthy volunteers.
- Trial name
- NCT02231840
- Where
- United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Anxiety, Loneliness
Loneliness and Health Outcomes in the High Need Population
The high need population are patients who have three or more chronic diseases and have a functional limitation in their ability to take care for themselves.
- Conditions
- Anxiety, Loneliness, Depression, Alcohol Use Disorder
- Trial name
- NCT05484258
- Testing
- Shared Medical Visit
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Healthy
Functional Neuroimaging of Alcoholism Vulnerability (PIT)
This project compares Family History Positive (FHP) for alcoholism subjects to matched Family History Negative (FHN) subjects derived from the project Principal Investigator's National Institute on Alcohol Abuse and…
- Trial name
- CTNA (NCT01585168)
- Testing
- Memantine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Dependance
Cortical rTMS as a Tool to Change Brain Reactivity to Alcohol Cues
The goal of this investigation is to determine if, in heavy alcohol users, a single session of transcranial magnetic brain stimulation (TMS) over a brain region involved in craving (medial prefrontal cortex) and a brain region…
- Trial name
- ARC4 (NCT02939313)
- Testing
- medial prefrontal cortex, dorsolateral prefrontal cortex
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina