Clinical trials: Alcohol Addiction
Addiction, Substance Use Disorder
Group Version of CRAFT Compared to Self-Directed CRAFT Delivery and Non-intervention: a Three-armed RCT
The aim of this study is to determine whether a group format Community Reinforcement and Family Training (CRAFT) and Self-Directed CRAFT Delivery are more effective than non-intervention in terms of Concerned Significant Others…
- Conditions
- Addiction, Substance Use Disorder, Alcohol Use Disorder, Substance- Related Disorder
- Trial name
- NCT02510508
- Testing
- Group CRAFT, Self-Directed CRAFT Delivery, Non-intervention
- Where
- 6 sites in Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- IrisZorg
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Posttraumatic Stress Disorder, Depression
The Pitt Center for Emergency Responder Wellness
Emergency responders protect the public despite occupational hazards that threaten their mental health. The Pitt Center for Emergency Responder Wellness will be a clinical innovation hub that: 1) delivers accessible interventions…
- Conditions
- Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
- Trial name
- NCT05357586
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Common Mental Disorders, Alcohol Use Disorder
Mental Health and Well-being of People Who Seek Help From Their Member of Parliament
This is an observational study to assess the prevalence of common mental disorders and alcohol use disorders in a population of individuals seeking help from their Member of Parliament (MP) in the UK.
- Trial name
- NCT04203966
- Testing
- 12-item General Health Questionnaire (GHQ-12), WHO AUDIT (World Health Organization- Alcohol Use Disorders Inventory Tool)
- Where
- United Kingdom
- Volunteers
- 662 people, healthy volunteers welcome
- Sponsor
- King's College London
Alcohol Use Disorder, Human Immunodeficiency Virus
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART).
- Trial name
- NCT06139224
- Testing
- 4 week prebiotic consumption
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Alcohol; Use, Problem, Stress
A Behavioral Activation Intervention Administered in a College Freshman Orientation Course
The transition from high school to college is a developmentally sensitive period that is high risk for escalations in alcohol use.
- Conditions
- Alcohol; Use, Problem, Stress, Binge Eating, Depression
- Trial name
- NCT04038190
- Testing
- behavioral activation
- Where
- United States
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Alcohol Use Disorder
Impulsivity Domains and Subjective Response
Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol.
- Trial name
- NCT05929677
- Testing
- Alcohol
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jessica Weafer
Tobacco Abstinence
Varenicline For Smokers In Recovery From Alcohol Dependence
The goal of this proposal is to explore the potential effectiveness of varenicline to treat tobacco dependence among recovering alcoholic smokers who, as a group, are at high risk for tobacco-caused morbidity and mortality.
- Trial name
- NCT01092702
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder, Alcohol Use Disorder
Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth
The goal of this project is to evaluate the effectiveness of a family-based tobacco use prevention intervention directed at immigrant Latino parents of middle school aged youth as delivered in partnership with seven community…
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Drug Use Disorder, Smoking
- Trial name
- NCT01442753
- Testing
- Family-Skills Training
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Alcohol Abuse
Bone Density in Patients With Schizophrenia
People with chronic mental disorder such as schizophrenia and alcohol abuse are high risk groups for developing osteoporosis. To evaluate the prevalence of bone mineral density in men patients with schizophrenia with alcohol…
- Trial name
- NCT00540267
- Testing
- No Intervention
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Inje University
Alcohol Dependence
Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence), ondansetron a serotonin 3 antagonist medication approved to treat nausea) or their…
- Trial name
- NCT00183222
- Testing
- naltrexone (up to 50 mg/day) for 8 days; ondansetron (0.25 mg twice a day) for 8 days
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcoholism
Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)
The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area.
- Trial name
- NCT01063166
- Where
- Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Major Depressive Disorder, Generalized Anxiety Disorder
Cohort Study on Medical Students' Mental Health
The main objective of this study is to identify risk factors for depression among medical students by comparing them to students who completed their first year but did not enter the medical program (students not accepted into the…
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Suicidal Ideation, Alcoholism
- Trial name
- OSMOSE (NCT07305701)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Alcohol Drinking, Alcohol Use Disorder
Understanding Alcohol Reward in Social Context
In this study, the investigators examine whether emotional and social reward from alcohol varies depending on the social context of consumption.
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT03449095
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcoholism, Healthy
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics
This study was designed to learn more about the areas of the brain involved in the experience of positive and negative emotions.
- Trial name
- NCT00001675
- Where
- United States
- Volunteers
- 1,194 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol; Liver
CM for Patients With ALD After Liver Transplant
Alcohol associated liver disease (ALD) refers to liver injury, such as cirrhosis, that is caused by alcohol use. It affects 2 million adults in the U.S.
- Conditions
- Alcohol Use Disorder, Alcohol; Liver, Post Liver Transplant, Contingency Management
- Trial name
- NCT06304467
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arpan A. Patel, MD
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bipolar Disorders
Bipolar Disorder With Alcoholism in Han Chinese
The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes.
- Trial name
- NCT01188395
- Where
- Taiwan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Alcohol Use Disorder
Internet-delivered Therapy for Alcohol Misuse: Investigating Patient Preference for Self-guided or Guided Treatment
Internet-delivered cognitive behaviour therapy (ICBT) shows promise as a method of treating alcohol misuse. In this form of treatment, patients complete online lessons over several weeks that assist patients in developing skills…
- Trial name
- NCT04611854
- Testing
- Guidance, ICBT for alcohol misuse
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Regina