Clinical trials: Alcohol Addiction
Alcohol-related Liver Disease, Alcohol Use Disorder
Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden.
Excessive alcohol use is a leading risk factor for preventable disability and death. Alcohol-related liver disease (ALD) is one of the better-known detrimental consequences of alcohol abuse and is the main cause of…
- Conditions
- Alcohol-related Liver Disease, Alcohol Use Disorder, Metabolic and Alcohol Related/Associated Liver Disease, Metabolic Disfunction Associated Steatotic Liver Disease
- Trial name
- StopALD (NCT06403332)
- Testing
- brief intervention
- Where
- 2 sites in Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Alcohol, Drinking
Michigan SPARC Trial
Unhealthy alcohol use is a major contributor to morbidity and mortality in the US. Although effective prevention for unhealthy alcohol use and medication treatment for alcohol use disorders (AUDs) can be provided in primary care…
- Conditions
- Alcohol, Drinking, Alcohol Use Disorder (AUD)
- Trial name
- MI-SPARC (NCT04861792)
- Testing
- Michigan SPARC Quality Improvement Intervention
- Where
- United States
- Volunteers
- 9,590 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alcoholism
Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism.
- Trial name
- NCT00612352
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Use Disorder
Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers
This study will examine the neural mechanisms underlying both spontaneous behavior change and behavior change in response to a brief intervention among problem drinkers.
- Trial name
- NCT03457077
- Testing
- Brief intervention
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcohol Dependence
A Study of Brain Receptor Occupancy in Healthy Subjects
To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.
- Trial name
- NCT01232439
- Testing
- opioid receptor kappa antagonist
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcoholism
The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects
This investigation will assess the effectiveness of topiramate in reducing ethanol consumption by alcohol dependent subjects. It also will seek to establish whether topiramate can be safely used in this population including…
- Trial name
- NCT00329407
- Testing
- Topiramate (Topamax)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcohol Use Disorder
Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)
This clinical trial aims to test the effectiveness and safety of semaglutide, a GLP-1 receptor agonist, in treating moderate to severe alcohol use disorder (AUD) in Veterans.
- Trial name
- CRAVE (NCT07218354)
- Testing
- Semaglutide
- Where
- 19 sites in United States
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Phase 1b Study of DCR-AUD in Healthy Volunteers
The goal of this clinical trial is to test the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of of repeat doses of DCR-AUD in adult healthy volunteers who are social drinkers.
- Trial name
- NCT05845398
- Testing
- DCR-AUD
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Alcohol Use Disorder
Considering Healthier Drinking Options in Collaborative Care
The purpose of this study is to evaluate the effectiveness of a collaborative care intervention for evidence based management of alcohol use disorders in primary care settings within the Veterans Administration Puget Sound Health…
- Trial name
- CHOICE (NCT01400581)
- Testing
- Collaborative Care Intervention
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alcohol Use Disorder (AUD), Alcohol Drinking
Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder
The goal of this study is to learn more about how a nutritional supplement "ketone ester" (deltaG ®) has an effect on brain and heart function and on alcohol consumption in individuals with and without alcohol use disorder.
- Trial name
- NCT05015881
- Testing
- Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", FDG
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcoholism, HIV Infection
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes…
- Conditions
- Alcoholism, HIV Infection, Homosexuality, Kaposi's Sarcoma
- Trial name
- NCT00001294
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Alcohol Use Disorder, Intermittent Explosive Disorder
Neural Correlates During Alcohol Intoxication
Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and…
- Trial name
- NCT06118580
- Testing
- Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Alcohol Use Disorder
INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers
In alcohol use disorder (AUD) and matched healthy control (HC) men and women, the proposed research examines the effects of MIFE, with demonstrated preclinical effects on drinking-related behaviors, compared with placebo on a…
- Trial name
- NCT02989662
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder
Phosphatidylethanol-Based Contingency Management for Housing
The investigators will evaluate the efficacy of contingency management (CM) in reducing alcohol use in individuals experiencing unstable housing but who are currently housed in shelters.
- Trial name
- NCT04038021
- Testing
- Phosphatidylethanol-based Contingency Management, Non-Contingent Control
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington State University
Alcohol Use Disorder
Preliminary Effectiveness of Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality
State the scientific aim(s) of the study, or the hypotheses to be tested. The purpose of the current study is to evaluate the usage and acceptability of the Soberlink's blood alcohol concentration (BAC) unit in collaboration with…
- Trial name
- Soberlink (NCT04380116)
- Testing
- Soberlink
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Drinking, Alcohol Use Disorder (AUD)
Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design
The study investigates the effects of alcohol consumption on social and individual behaviors using a within-subject design. Participants, aged 21-30, will attend two laboratory sessions approximately one week apart, participating…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder (AUD), Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT07125534
- Testing
- Alcohol beverage, Control - non alcoholic beverage
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcoholism
Alcohol Interaction Study
The purpose of this study is understand the effects of GSK114814 and alcohol in healthy volunteers when taken together.
- Trial name
- NCT01181908
- Testing
- single dose
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Focus: Effects of Nicotine and Alcohol on Brain Circuits
Neural Mechanisms Underlying Nicotine and Alcohol Combinations
Nicotine and alcohol are frequently used together and their combined use contributes to more than half a million deaths each year, with more alcoholics dying from smoking-related diseases than from alcohol-related diseases.
- Trial name
- QfMRI (NCT02049268)
- Testing
- Nicotine + Alcohol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcoholism
Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence
Validation of a Test System to develop new medications for alcoholism (TEMA) The 'TEMA', a progressive-work alcohol self-administration paradigm, can be validated by reproducing the effect of Acamprosate and prove the effect of…
- Trial name
- TEMACA (NCT03634917)
- Testing
- Acamprosate Calcium, Calcium Carbonate
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden