Clinical trials: Alcohol Addiction
Alcohol Use Disorder, Alcohol Associated Liver Disease
A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease
This study seeks to develop and test a novel digital pill system (DPS) that measures real-time medication ingestion and pairs it with a cognitive behavioral therapy (CBT)-based intervention to provide personalized, data-driven…
- Conditions
- Alcohol Use Disorder, Alcohol Associated Liver Disease, Medications for Alcohol Use Disorder, Behavioral Medicine
- Trial name
- NCT07553377
- Testing
- AcamproSync
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol-associated Liver Disease
Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)
The goal of this project is to improve provision of integrated medications for alcohol use disorder (MAUD) with brief counseling for patients with alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) in…
- Trial name
- NCT07525258
- Testing
- Implementation Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Addiction
Disulfiram as a Modulator of Amyloid Precursor Protein-processing
A causal therapeutic approach for treatment of Alzheimer's disease has not been established so far. The protein ADAM10 represents a promising target for an A-beta peptide preventing strategy.
- Trial name
- DIMAP (NCT03212599)
- Testing
- Disulfiram
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Alcohol Abuse
Brief Intervention for Heavy Drinkers
The purpose of the study is to determine whether a brief intervention (a short conversation build on the principles of motivational interviewing) is effective in lowering self reported alcohol use in heavy drinkers.
- Trial name
- NCT00728767
- Testing
- Brief intervention, Control group
- Where
- 9 sites in Denmark
- Volunteers
- 772 people
- Sponsor
- University of Southern Denmark
Alcohol Use Disorder
Effect of Adapted Physical Activity on Sleep Quality in People With Alcohol Use Disorder
This feasibility study aims to assess interest, recruitment, and adherence to a supervised physical activity (APA) program among individuals with Alcohol Use Disorder (AUD).
- Trial name
- APhysOH (NCT06706349)
- Testing
- APA managed by qualified instructor, Autonomous APA
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Alcoholism
Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking With Peer Phone Support
Hazardous drinking is common among Veteran primary care patients and increases risk for more costly and complex medical problems over the long-term. Yet, the vast majority of these Veterans go untreated.
- Trial name
- PS-Stand Down (NCT05473598)
- Testing
- Stand Down app, Peer-Supported Stand Down, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 234 people
- Sponsor
- VA Office of Research and Development
HIV Infections, Alcohol Use Disorder
An Effectiveness Trial of the PrEP for WINGS Study
(Effectiveness Aim 1) To test the comparative effectiveness of PreP for WINGS versus PrEP alone on primary outcomes of increasing PrEP initiation measured by self-report/medical records, recent adherence and longer-term adherence…
- Conditions
- HIV Infections, Alcohol Use Disorder, Violence, Gender-Based
- Trial name
- PFW (NCT06853314)
- Testing
- PrEP for WINGS, PrEP Decision Aid
- Where
- United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcoholic Hepatitis
Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.
Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease. Maddrey's discriminant function (mDF) >32 defines the severe form of AH, which is associated with a high mortality.
- Trial name
- AH2023 (NCT05883891)
- Testing
- prothrombin time
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alcohol Use Disorder (AUD)
Acceptability and Feasibility Study of Non-alcoholic Beverages
This project will elucidate the acceptability and feasibility of incorporating provision of non-alcoholic beers into alcohol use disorder treatment, for patients interested in using non-alcoholic beers as part of their recovery…
- Trial name
- NCT07451574
- Testing
- Non-alcoholic beer, Sparkling water
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Alcohol Use Disorder
Neurofeedback Training of Metacognition in Subjects With Alcohol Use Disorder. Disorder Induces Neural Modifications: an Event-related Potentials Study
Addressing cognitive deficits in alcohol use disorder (AUD) supports recovery. Impaired metacognitive functioning in AUD causes compromised recognition of the interoceptive state leading to the maintenance of alcohol abuse…
- Trial name
- NCT05913518
- Testing
- Neurofeedback active
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Brugmann University Hospital
Alcohol Use Disorder
Ibudilast and Withdrawal-Related Dysphoria
Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options.
- Trial name
- NCT03489850
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder (AUD), Alcohol Consumption
Probenecid Administration for Alcohol Craving and Consumption
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Consumption, Craving
- Trial name
- PROB2 (NCT07118618)
- Testing
- Probenecid Oral Tablet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brown University
Alcohol Dependence
Aripiprazole Effects on Alcohol Reactivity and Consumption
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving compared to placebo.
- Trial name
- NCT00183235
- Testing
- aripiprazole (up to 15 mg/day) for 8 days
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Bipolar Disorder
Cognitive-Behavior Therapy for Young Adults With Bipolar Disorder
The aim of the study is to develop and pilot test a cognitive-behavioral (CBT) intervention for young adults, ages 18-24 with bipolar disorder.
- Trial name
- NCT01176825
- Testing
- cognitive-behavior therapy (CBT)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Massachusetts General Hospital
Alcohol Abuse, Drug Abuse
Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population
In adolescents, mental health problems are frequently associated with substance misuse, even considered a risk factor for alcohol abuse and dependence.
- Conditions
- Alcohol Abuse, Drug Abuse, Mood Disorder, Anxiety Disorder
- Trial name
- NCT01595568
- Testing
- Personality-targeted interventions
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Justine's Hospital
Alcohol Use Disorder, Alcoholism
Naltrexone in AUD Reward Drinkers
This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive…
- Trial name
- NCT05028062
- Testing
- XR-NTX 380 mg, intramuscular injection, Medical Management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Alcohol; Use, Problem
Probiotics, Immune Function, and the Brain in Alcohol Consumers
This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no…
- Trial name
- NCT05232682
- Testing
- Seed DS-01 Daily Synbiotic
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Alcoholism
New Therapeutic Strategies for Inhibitory Control in Alcoholism
This experimental research studies the efficacy of two different treatments for inhibitory control improvement in alcohol-dependent individuals, one consisting of Retrieval-Extinction Learning ( alcohol AAT Task) and the other…
- Trial name
- NCT03058276
- Testing
- Retrieval-Extinction Learning, rTMS, SAM
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Hospital Universitario 12 de Octubre
Alcohol Drinking in College
Addiction Risk: Mindset Induction Effect on Brief Intervention
Brief Interventions (BI) based on Motivational Interviewing are effective to reduce alcohol use. In this study the investigators test the hypothesis that that an open Mindset increases the positive effects of BI.
- Trial name
- AddRiskStud (NCT03338491)
- Testing
- Induction of Implemental Mindset, Induction of Deliberative Mindset
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Konstanz