Clinical trials: Alcohol Craving, active
Healthy Volunteers, Alcohol Use Disorder (AUD)
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Background: Alcohol use disorder (AUD) is a leading cause of disease and death worldwide. New treatments for AUD are needed. Dopamine, a chemical that carries signals between brain cells, is thought to play a role in alcohol…
- Trial name
- NCT06484075
- Testing
- Siemens 3T PRISMA MR Scanner, PET/CT Scanner, Suvorexant
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Consumption, Heavy Drinker
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
- Conditions
- Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
- Trial name
- NCT06136195
- Testing
- Mavoglurant
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Transcranial Ultrasound Stimulation
Transcranial Ultrasound Stimulation as a Neuromodulation Therapy for Craving and Relapse Behaviors in Alcohol Use Disorder.
This study aims to evaluate the efficacy of transcranial ultrasound stimulation in reducing cravings and preventing relapse in individuals with alcohol use disorders.
- Trial name
- NCT06867224
- Testing
- Active TUS-vmPFC
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Use Disorder
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
This study is testing a new treatment called IR-TMS (image-guided, robot navigated transcranial magnetic stimulation) to see if it can help people who drink too much alcohol to reduce the amount they drink.
- Trial name
- NCT06648642
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Craving, Alcohol Drinking
Examining the Effectiveness of Dynamic Visual Noise (DVN) for Reducing Alcohol Cravings and Consumption in College Students
The goal of this clinical trial is to examine whether dynamic visual noise (DVN), a short video array of rapidly moving black and white squares, reduces cravings for and consumption of alcohol in college students who drink…
- Trial name
- NCT07157124
- Testing
- Dynamic Visual Noise (DVN), Static Visual Noise (SVN)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Wyoming
Alcohol Addiction, Alcoholism
A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol Dependence
Alcohol addiction (AD) is a chronic relapsing disorder with currently limited pharmacological treatment options. Alcohol craving, a hallmark symptom of AD that drives relapse in patients, is only insufficiently treated by…
- Trial name
- ICONICplus (NCT06845124)
- Testing
- Cannabidiol capsules, Naltrexone (drug)
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Use Disorder (AUD), Alcohol Consumption
Probenecid Administration for Alcohol Craving and Consumption
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Consumption, Craving
- Trial name
- PROB2 (NCT07118618)
- Testing
- Probenecid Oral Tablet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brown University
Alcohol Use Disorder, Inflammatory Response
Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use
The study design consists of a randomized, double-blind, placebo-controlled study of low dose endotoxin. Individuals with current AUD (n=32) and matched controls without AUD (n=32) will be randomly assigned to receive a single…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving
- Trial name
- NCT07452146
- Testing
- Endotoxin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder
Evaluating Cannabidiol as a Novel Anticraving Medication for Alcohol Use Disorder
This human laboratory study aims to assess the effects of cannabidiol on alcohol consumption and craving in participants with alcohol use disorder.
- Trial name
- NCT06512389
- Testing
- Oral solution
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder, Severe
Impact of Omega 3 in Alcohol Use Disorder
The goal of this clinical trial is to investigate the biological pathways underlying the beneficial effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on mental health in patients with alcohol use disorder.
- Trial name
- W3-AUD (NCT05899660)
- Testing
- Active Comparator: Omega-3
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Alcohol Use Disorder (AUD), Obesity (BMI Equal to or >30)
Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes
This study will examine two doses of 1.0 mg and 2.0 mg of Semaglutide versus placebo in patients with Alcohol Use Disorder (AUD) and Obesity (Ob) to assess if these doses improve alcohol craving, stress and alcohol use outcomes.
- Trial name
- SEMA AUD (NCT07772960)
- Testing
- Semaglutide 1.0 mg, Semaglutide 2.0 mg
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Alcohol Related Liver Disease
Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism
This randomized study will examine whether a 12-week supervised home-based endurance exercise program can reduce alcohol use and alcohol craving in adults with alcohol use disorder (AUD) and alcohol-related liver disease (ALD).
- Trial name
- NCT07824089
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Alcohol Use Disorder
Effects of Olfactory Stimuli in Virtual Reality Cue Exposure on Craving and Attentional Bias in Alcohol Use Disorder
Alcohol use disorder (AUD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol-often accompanied by an attentional bias toward alcohol-related…
- Trial name
- OLFA-VR (NCT07667790)
- Testing
- VR-CE
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Use Disorder (AUD), Suicide Ideation
A MRT to Optimize a JITAI for Alcohol Craving and Suicide Ideation
This study will develop and evaluate a brief, personalized, single-session telehealth intervention combined with a four-week just-in-time adaptive intervention (JITAI) delivered via text messaging for adults with alcohol use…
- Trial name
- NCT07922590
- Testing
- Text Message (to remind of Integrated Plan content)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder (AUD), Alcohol-Related Disorders
Body-Focused Mindfulness as an Add-on Intervention in Inpatient Alcohol Use Disorder Treatment (MBI-AUD-PL)
The goal of this clinical trial is to learn if a body-focused mindfulness program can help people with alcohol use disorder (AUD) feel more connected to their bodies and manage their emotions better.
- Trial name
- MBI-AUD-PL (NCT07706660)
- Testing
- Body-Focused Mindfulness Intervention, Standard Psychoeducation
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Alcohol-Related Disorders, Alcoholism
Comparing Combined Behavioral Intervention and Ericksonian Hypnotherapy for Alcohol Addiction
This clinical study is being conducted to compare the effectiveness of two psychological treatments for alcohol addiction: Combined Behavioral Intervention (CBI) and Ericksonian Hypnotherapy (EH).
- Conditions
- Alcohol-Related Disorders, Alcoholism, Substance-related Disorders
- Trial name
- NCT06916754
- Testing
- Combined Behavioral Intervention, Ericksonian Hypnotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Beykoz University
Normal Subjects
An Exploratory Preliminary Study on the Effect of Combined Transcranial Photobiomodulation(tPBM)-Transauricular Vagus Nerve Stimulation(taVNS) on Alcohol Craving and Neurophysiological Marker in Drinkers (in South Korea)
Study Summary This pilot study aims to explore the mechanisms and effects of non-invasive neurostimulation in individuals with alcohol use, in order to develop a more accessible and sustainable treatment approach for alcohol use…
- Trial name
- NCT07071493
- Testing
- tPBM Group, taVNS Group, Combined Treatment Group: Stimulation Program (5 Weeks)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification
Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals.
- Conditions
- Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification, Craving
- Trial name
- NCT07148843
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University