Clinical trials: Alcohol Dependence
Bipolar Disorder, Alcohol Dependence
Optimizing Pharmacotherapy for Bipolar Alcoholics
The purpose of this study is to test the efficacy of naltrexone and valproate in the treatment of comorbid bipolar disorder and alcohol dependence.
- Trial name
- NCT00302133
- Testing
- Naltrexone hydrochloride
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission.
- Trial name
- NGFN PLUS TP13 (NCT01503931)
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Heavy Drinking, Alcohol Abuse
Effects of Acute Exercise on Various Parameters in Individuals With Alcohol Use Disorders
The purpose of this research is to examine the effects of exercise of different intensities on psychological, physiological, biochemical, physiological and alcohol-related parameters in individuals with alcohol use disorders…
- Conditions
- Heavy Drinking, Alcohol Abuse, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- NCT02664727
- Testing
- The effects of acute exercise in heavy drinkers, The effects of acute exercise in alcoholic patients
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Alcohol Dependence, Cocaine Dependence
Combined Treatment for Cocaine-Alcohol Dependence - 1
The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy can be helpful in patients who want to stop using cocaine and alcohol.
- Trial name
- NCT00218569
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Substance Abuse Problem, Alcohol Abuse
Designing a Mobile App for Veterans With Substance Use Problems
The purpose of this study is to increase access for rural Veterans to evidence-based, person-centered, individually tailored treatment for alcohol use problems.
- Conditions
- Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01812187
- Testing
- SHIFT Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Alcohol Dependence
Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence
This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
- Trial name
- NCT02557815
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alcohol-dependence
Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants
Alcohol-dependence is the most widespread addiction in Western countries and leads to a wide range of impairments at cerebral and cognitive levels.
- Trial name
- ALCOLAT (NCT01633905)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alcohol Dependence
Cerebral Hemodynamics With rTMS in Alcohol Dependence
The present study measures the cerebral hemodynamic indices of alcohol dependent patients and observe the relative changes in these parameters with rTMS application.
- Trial name
- NCT02446067
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Alcohol Dependence, Alcohol Abuse
Community Reinforcement and Family Training (CRAFT) for Treatment-resistant Individuals With Alcohol Use Disorders
The present study examines the efficacy of the Community Reinforcement and Family Training (CRAFT) for Concerned Significant Others (CSOs) of individuals with alcohol use disorders (AUDs) using a randomized waiting list (WL)…
- Trial name
- CRAFT (NCT02112396)
- Testing
- Community Reinforcement and Family Training
- Where
- Germany
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Alcohol-Related Disorders, Alcohol Dependence
Acamprosate to Reduce Symptoms of Alcohol Withdrawal
This study will examine whether a new drug called acamprosate can be helpful for alcohol withdrawal, a result of drinking high amounts of alcohol for long periods of time.
- Conditions
- Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Healthy Volunteer
- Trial name
- NCT00106106
- Testing
- NMR-spectroscopy, Oral acamprosate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Dependence, Veterans
Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot Trial
The goal of the proposed project is to improve the primary care treatment of veterans with alcohol dependence. Alcohol dependence is a common behavioral health problem among veterans treated in VA primary care clinics.
- Trial name
- NCT00461890
- Testing
- Injectable Naltrexone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alcohol Dependence
ALK29-002: A Study of Baclofen Formulations in Healthy Adults
The purpose of this study is to determine the pharmacokinetics, safety, and tolerability of different baclofen formulations.
- Trial name
- NCT00802035
- Testing
- Baclofen IR, Baclofen ER
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Alcohol Dependence
ALK33-001: A Study of RDC-0313 Administered to Healthy Adults
The purpose of this study is to determine the pharmacokinetics, safety, and tolerability of RDC-0313 following oral administration.
- Trial name
- NCT00800319
- Testing
- RDC-0313
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Alcohol Dependence
A Study of Brain Receptor Occupancy in Healthy Subjects
To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.
- Trial name
- NCT01232439
- Testing
- opioid receptor kappa antagonist
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcohol Dependence
Effectiveness of Extended Telephone Monitoring
The purpose of this study is to determine the effectiveness of extended telephone monitoring for alcohol-dependent patients receiving intensive outpatient treatment.
- Trial name
- ETM (NCT00194103)
- Testing
- Telephone Monitoring and Feedback, Telephone Monitoring and Counseling
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Dependence
Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence), ondansetron a serotonin 3 antagonist medication approved to treat nausea) or their…
- Trial name
- NCT00183222
- Testing
- naltrexone (up to 50 mg/day) for 8 days; ondansetron (0.25 mg twice a day) for 8 days
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida