Clinical trials: Alcohol Dependence
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Alcohol Abuse, Alcohol Use Disorder
Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
The primary aims of the study are to assess the user experience and initial efficacy of a mobile application designed to reduce problematic alcohol use.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Abuse, Episodic
- Trial name
- ALCMOD (NCT04286867)
- Testing
- Alcohol Moderation Mobile Application, Alcohol Moderation Drink Tracker
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kent State University
Alcohol Dependence
Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism
Alcoholism is the third leading cause of preventable death in the US, accounting for 80,000 deaths annually. Almost 18 million US adults have alcohol use disorder (AUD); however, approved medications for the treatment of AUD has…
- Trial name
- NCT02901041
- Testing
- Zonisamide, Take Control
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Boston University Charles River Campus
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Abuse
Human Alcohol Seeking Despite Aversion
Prolonged alcohol use results in drinking despite resultant problems and adverse consequences. The investigators propose to test a laboratory model of human seeking despite aversion to use as an early marker of disease onset, and…
- Trial name
- NCT03648840
- Testing
- Aversive Cue, Neutral Cue
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcoholism
Varenicline for Alcohol Dependence
The primary objective of this study is to assess the efficacy of varenicline in reducing the proportion of heavy drinking days during the last 8 weeks of treatment in subjects with alcohol dependence confirmed by Diagnostic and…
- Trial name
- NCIG 003 (NCT01146613)
- Testing
- Varenicline
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Progesterone Effect on Individuals Diagnoses With AD and PTSD.
This is a randomized control trial with an anticipated 36 participants diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence. Participants will be randomized to receive either progesterone (200 mg.
- Trial name
- NCT02187224
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Insomnia
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & Relapse
Insomnia is a highly prevalent disorder in those recovering from alcoholism. It has been associated with anxiety and depressive symptoms, as well as an increased risk of relapse back to the drinking.
- Trial name
- NCT01987089
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol Dependence
The long-term safety and efficacy of nalmefene hydrochloride at 20 mg in patients with alcohol dependence will be evaluated in a multicenter, open-label, uncontrolled trial.
- Trial name
- NCT02382276
- Testing
- Nalmefene hydrochloride
- Where
- 7 sites in Japan
- Volunteers
- 405 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
PTSD, Alcohol Abuse
Helping Families Help Veterans With PTSD and Alcohol Abuse: An RCT of VA-CRAFT
This project begins to evaluate the effectiveness of a web-based family outreach tool that is designed to promote treatment engagement among Veterans with posttraumatic stress disorder (PTSD) or alcohol use disorders (AUDs) but…
- Trial name
- NCT01678196
- Testing
- VA-CRAFT, Control
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Effects of Cannabidiol in Alcohol Use Disorder
The goal of the proposed project is to begin rigorous study of the clinically relevant effects of non-psychoactive phytocannabinoid cannabidiol (CBD) in patients with severe alcohol use disorder (AUD).
- Trial name
- NCT03252756
- Testing
- Phytocannabinoid cannabidiol (CBD)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NYU Langone Health
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention for HIV-affected Couples Who Drink Alcohol in Malawi
A couples-based alcohol-reduction and economic and relationship-strengthening intervention for HIV-affected couples in Malawi.
- Trial name
- NCT04906616
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Alcohol Dependence, Anxiety Disorder
Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder
The proposed design is a single-group open-label trial. Qualified consenting participants with active alcohol dependence and primary or secondary anxiety disorder will receive monitored disulfiram and lorazepam, in the context of…
- Trial name
- NCT00721526
- Testing
- disulfiram plus lorazepam
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Alcohol Dependence, Insomnia
Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
Insomnia and other sleep abnormalities are common, persistent, and associated with relapse in alcohol-dependent patients. The overall, long-term objectives of the proposed research are to investigate the neurophysiologic…
- Trial name
- MA (NCT01014533)
- Testing
- Gabapentin dispensed to subject.
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Dr. Kirk Brower
Alcoholism
Understanding Treatment Response With Naltrexone Among White Alcoholics
This is a study involving treatment for alcohol dependence among males of European or Asian decent. The ultimate aim of this line of investigation is to further establish a genetic link between alcohol dependence and treatment by…
- Trial name
- DEFINE II (NCT00817089)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited brain activation and increases brain activation…
- Trial name
- NCT02949934
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking, Alcohol Abuse
Using Counter Attitudinal Advocacy to Change Drinking Behavior
High volume drinking by young adults has proven resistant to change, so new approaches are needed. We adapt a theory-based attitude change strategy for use in alcohol prevention.
- Trial name
- NCT04042909
- Testing
- Counter Attitudinal Advocacy, Personalized Normative Feedback
- Where
- 2 sites in United States
- Volunteers
- 591 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Dependence
Pilot Study of Depot NTX in Homeless Veterans
Almost 200,000 veterans are homeless each night, about one-quarter to one-third of homeless adults in the U.S. Half need treatment for a substance use disorder, usually alcohol dependence, but sobriety is often required to access…
- Trial name
- NCT01155869
- Testing
- Depot naltrexone, Oral Naltrexone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester