Clinical trials: Alcohol Disorders
Alcoholism, Schizophrenia
Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism
This placebo-controlled study is designed to evaluate the efficacy of glycine, an agonist of the glycine-B co-agonist site of the NMDA receptor, on alcohol consumption and craving as well as negative symptoms in schizophrenia.
- Trial name
- NCT00338598
- Testing
- Glycine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Binge Drinking
Cognitive Retraining and Brain Stimulation for Alcohol Use
The overarching goal of this study is to determine whether combined cognitive training and Transcranial Direct Current Stimulation (tDCS) reduces drinking in high-risk drinkers.
- Trial name
- NCT02045108
- Testing
- Active Retraining, Active TDCS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- The Mind Research Network
Alcohol Use Disorder
Preliminary Effectiveness of Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality
State the scientific aim(s) of the study, or the hypotheses to be tested. The purpose of the current study is to evaluate the usage and acceptability of the Soberlink's blood alcohol concentration (BAC) unit in collaboration with…
- Trial name
- Soberlink (NCT04380116)
- Testing
- Soberlink
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Alcoholic Hepatitis
Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
This study will compare two different treatments of acute alcoholic hepatitis. The current standard of care is treatment with corticosteroids (methylprednisolone).
- Trial name
- NCT01809132
- Testing
- Anakinra, Pentoxifylline, Zinc Sulfate
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Mack Mitchell
Alcohol Use Disorder, Tobacco Smoking
Laboratory Screening of Lorcaserin for Alcohol Use Disorder
Heavy-drinking smokers, including those with alcohol use disorder (AUD), are at increased risk for numerous negative health outcomes relative to those who use alcohol or cigarettes only.
- Trial name
- NCT04396847
- Testing
- Lorcaserin Oral Tablet
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The Mind Research Network
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Substance Related Disorders
Screening and Brief Advice to Reduce Teen Substance Use
The purpose of this study is to test the effectiveness of a brief intervention for alcohol and drug use in adolescents that a primary care doctor can give in his/her office.
- Trial name
- NCT00227877
- Testing
- cSBA - New England, USA, cSBA - Prague, CZR
- Where
- 6 sites in United States, Czechia
- Volunteers
- 2,695 people
- Sponsor
- Boston Children's Hospital
Mental Health Issue, Alcohol Use Disorder
Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
The current study aims to assess the acceptability and feasibility of an adapted version of Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS) for use with signing Deaf adults.
- Conditions
- Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- NCT05520190
- Testing
- Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Rochester
Alcohol Use Disorder
Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
This will be a single site randomized, 2-session, within-subject cross-over design pilot study. 20 enrolled (of 30 consented) subjects reporting varying levels of binge and high intensity drinking, defined as at least 2 episodes…
- Trial name
- NCT04971681
- Testing
- Low frequency repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Major Depressive Disorder, Alcohol Use Disorder
STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse
The purpose of this study is to determine if having an alcohol use disorder affects recovery from depression, and also whether recovery from depression in patients who have alcohol use disorders is also accompanied by improvement…
- Trial name
- NCT00369746
- Testing
- citalopram
- Where
- United States
- Volunteers
- 674 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders
To use pregnenolone (PREG; 300; 500mg) daily versus placebo (PLA) as a probe to assess the role of neuroactive steroids in individuals with alcohol use disorder (AUD).
- Trial name
- NCT03872128
- Testing
- Pregnenolone300, Pregnenolone500
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Alcohol Drinking, Veterans
Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder
Alcohol contributes to 88,000 deaths and costs an estimated $223 billion annually in the United States. Alcohol use disorder (AUD) is highly prevalent in veterans.
- Trial name
- NCT03987581
- Testing
- Cognitive Behavioral Therapy (CBT), Mobile Contingency Management (mCM), Long-term incentive
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Alcoholism, Alcohol Dependence
Baclofen for Treating Anxiety and Alcoholism
Background: Baclofen is a drug used to control muscle stiffness in people with neurological diseases. Some studies suggest that baclofen may reduce alcohol craving and use.
- Conditions
- Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems, Alcohol Drinking
- Trial name
- NCT01751386
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Dependence, Bipolar Disorder
Acamprosate vs. Placebo in Bipolar Alcoholics
To conduct a double-blind, randomized, placebo-controlled outpatient clinical trial of acamprosate in individuals with alcohol dependence and bipolar disorder who are also receiving mood stabilizing medication.
- Trial name
- NCT00466661
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking, Marijuana
Marijuana's Impact on Alcohol Motivation and Consumption
This laboratory study will employ a repeated measures experimental design to examine the effect of high (7.2% THC) and moderate (3.1% THC) dose of marijuana, relative to placebo, on alcohol craving and on behavioral economic…
- Trial name
- NCT02983773
- Testing
- THC 7.2%, THC 3.1%
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcoholism
N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol Dependence
The purpose of this study is to determine whether: (1) the combination of N-acetylcysteine + high-dose naltrexone (150 mg) works better than high-dose naltrexone (150 mg) alone in reducing alcohol drinking; and (2) high-dose…
- Trial name
- NCT01214083
- Testing
- N-acetylcysteine + high-dose naltrexone (150 mg), High-dose naltrexone (150 mg) alone, Low-dose naltrexone (50 mg) alone
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- VA Office of Research and Development
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Opioid-use Disorder, Alcohol Use Disorder
Medication Development for Opioid and Alcohol Abuse
The present proposal will evaluate the ability of gabapentin maintenance to reduce the abuse liability of alcohol, oxycodone, and alcohol in combination with oxycodone in participants with both Opioid Use Disorder and Alcohol Use…
- Trial name
- NCT03205423
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Pilot Evaluation of the Empower Neuromodulation System in AUD Patients
This study evaluates the effects of peripheral nerve stimulation on alcohol craving and consumption in participants with alcohol use disorder (AUD).
- Trial name
- NCT03983317
- Testing
- Empower Neuromodulation System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Theranova, L.L.C.