Clinical trials: Alcohol Disorders
Nonalcoholic Fatty Liver Disease, Light-to-moderate Alcohol Consumption
Alcohol Consumption and Type 2 Diabetes Mellitus Risk in Nonalcoholic Fatty Liver Disease
This study explored the cross-sectional and prospective associations between light-to-moderate alcohol consumption (LMAC) and risk of type 2 diabetes mellitus (T2DM) in individuals with nonalcoholic fatty liver disease (NAFLD).
- Conditions
- Nonalcoholic Fatty Liver Disease, Light-to-moderate Alcohol Consumption, Type2 Diabetes Mellitus
- Trial name
- NCT03847116
- Where
- China
- Volunteers
- 14,014 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Alcohol Drinking, Alcohol Abuse
Novel Real-world Methods in Social Drinkers and AUD
This research project proposes a novel approach to elucidate the biological adaptations associated with Alcohol Use Disorder and to assess whether such adaptations are predictive of higher alcohol craving in response to both…
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- ALR (NCT05155176)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Yale University
Stress, Alcoholism
Chronic Alcohol and Brain Stress Circuit Response
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol…
- Trial name
- NCT01031264
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol Abuse
Internet-delivered Cognitive Behavior Therapy for Problematic Alcohol Use in a Working Life Setting
Internet-based cognitive behavioral treatment (ICBT) for mental health issues has been successfully implemented in routine health care and research indicates that ICBT can also be applied to decrease problematic alcohol use in…
- Trial name
- Simba (NCT06774716)
- Testing
- Internet-based cognitive behavioural treatment and relapse prevention, Face-to-face cognitive behavioural treatment or short-term psycodynamic therapy with relapse prevention
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Stockholm University
Alcohol Abuse, Drug Abuse
Personality-targeted Interventions for Adolescent Alcohol Misuse
Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press).
- Conditions
- Alcohol Abuse, Drug Abuse, Depression, Panic Disorder
- Trial name
- Preventure (NCT00344474)
- Testing
- PRE-Venture: Personality Risk Education
- Where
- United Kingdom
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- King's College London
Chronic Liver Disease
Mobile Chat Messaging for Alcohol Reduction in Patients With Chronic Liver Diseases
The goal of this pilot randomized controlled trial is to evaluate the trial feasibility and acceptability of mobile chat messaging for reducing alcohol use among patients with chronic liver diseases.
- Trial name
- NCT06587568
- Testing
- Mobile chat messaging, Screening, brief intervention and referral to treatment
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- The University of Hong Kong
Alcohol Abuse, Alcohol Use Disorder
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs).
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal
- Trial name
- NCT05619185
- Testing
- CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook
- Where
- United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cannabis Intoxication, Alcohol Intoxication
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis.
- Trial name
- NCT06293040
- Testing
- Cannabis, Alcohol
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Abuse
Health Explorer - Optimizing Alcohol Brief Interventions
The aims of the study are to develop and refine tailored motivational brief interventions that are parallel in structure but have varied delivery modalities (computer vs.
- Trial name
- NCT01370226
- Testing
- CBI, TBI
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Tobacco Use, Alcohol Abuse
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform
The goal of this study is to validate the TAPS-ESP as a screen and assessment that can be used in primary care for the screening and treatment of substance use.
- Conditions
- Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
- Trial name
- TAPS-ESP (NCT05476588)
- Testing
- Screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Major Depressive Disorder
A Study of LY2216684 in Healthy Participants
This study will evaluate the pharmacodynamic and pharmacokinetic interaction of LY2216684 with alcohol in healthy participants. This study will run approximately for 34 days.
- Trial name
- NCT01380691
- Testing
- LY2216684, Alcoholic beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcohol Addiction, Alcohol Dependence
Qi Gong as a Method of Craving Reduction in Severe Addict Patients
Craving arises in response to an affective tone that is associated with perceptual representations of a sensory object, rather than directly in response to the object.
- Trial name
- QICA (NCT03589118)
- Testing
- Qi Gong sessions
- Where
- 3 sites in France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcoholic Liver Disease, Severe Alcoholic Hepatitis
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
Alcoholic hepatitis carries a risk of high mortality at short term, especially in its severe form. Its diagnosis is confirmed by liver biopsy.
- Conditions
- Alcoholic Liver Disease, Severe Alcoholic Hepatitis, Alcoholic Cirrhosis
- Trial name
- COMADHAA (NCT04106518)
- Where
- 9 sites in France
- Volunteers
- 447 people
- Sponsor
- University Hospital, Lille
Alcoholic Hepatitis
Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid
Steroid is the treatment of choice in patients with severe alcoholic hepatitis. However, null- or partial responder of steroid treatment is recommended to consider liver transplantation.
- Trial name
- GraCiAH (NCT02442180)
- Testing
- G-CSF (Filgrastim injection), steroid
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Alcohol Abuse
Deep Repetitive Transcranial Magnetic Stimulation for Alcohol Use Disorder
dTMS intervention to reduce recurrent alcohol abuse among alcohol users who are abstinent for at least 5 days.
- Trial name
- NCT02691390
- Testing
- Active dTMS
- Volunteers
- 51 people
- Sponsor
- Soroka University Medical Center
Hiv, Alcohol Use, Unspecified
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as…
- Trial name
- NCT05241990
- Testing
- Practice Facilitation, Alcohol Stepped Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Substance Abuse
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings
Substance abuse and dependence is highly prevalent among people living with HIV and significantly exacerbates morbidity and mortality and accelerates HIV disease progression.
- Trial name
- NCT03092596
- Testing
- Patient-administered screening tool, Patient health navigator-administered screening tool, Patient health navigator-assisted linkage to treatment
- Where
- United States
- Volunteers
- 3,358 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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