Clinical trials: Alcohol Disorders
Healthy Volunteers, Alcohol Drinking Related Problems
A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder
Background: Problem drinking affects nearly half the people who drink alcohol. Drinking alcohol affects a person's social behavior and brain structure, but researchers don't have a good understanding of how.
- Conditions
- Healthy Volunteers, Alcohol Drinking Related Problems, Alcohol-Related Disorders
- Trial name
- NCT03535129
- Testing
- Real time fMRI neurofeedback
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Alcohol Abuse
Brief Electronic Intervention for Heavy Drinking and Sex Risk Among MSM Seeking HIV Testing
The overall objective of this research is to use both qualitative and quantitative data to inform the development of a technology-based intervention for heavy drinking and sexual risk behavior among men who have sex with men…
- Trial name
- NCT03435783
- Testing
- Brief Electronic Intervention, Attention-Matched Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brown University
Human Immunodeficiency Virus (HIV)
Alcohol Monitor Validation
This study will validate a wrist-worn alcohol monitor (BACtrack Skyn) in both laboratory and real-life settings.
- Trial name
- NCT03617705
- Testing
- Skyn Monitor Lab Session 1, Skyn Monitor Field Test with EMA App, Skyn Monitor Lab Session 2
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Florida
Binge Drinking, HIV
Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among Men Who Have Sex With Men (MSM)
This is a double-blind, placebo-controlled trial of 120 binge-drinking MSM to 12 weeks of naltrexone 50mg, to be taken in anticipation of heavy drinking.
- Trial name
- SayWhen (NCT02330419)
- Testing
- Naltrexone, Medical Management (MM) counseling for alcohol use:, Urinalysis for novel alcohol biochemical markers:
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol and Tobacco/Cannabis Use
FASD Prevention R33
This R33 application proposes to adapt and test an evidence-based behavioral intervention to decrease polysubstance use (i.e., alcohol and tobacco/cannabis) during pregnancy and lactation and prevent adverse clinical outcomes…
- Trial name
- R33 (NCT07828275)
- Testing
- Intervention, Usual Care
- Where
- South Africa
- Volunteers
- 184 people
- Sponsor
- Philadelphia College of Osteopathic Medicine
Alcoholic Hepatitis
Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease
Background: Alcoholic liver disease is one of the most important causes of chronic liver disease in this country. There is currently no treatment for chronic alcoholic liver disease other than abstinence.
- Trial name
- RCT SAMe (NCT00851981)
- Testing
- SAMe
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Loma Linda University
Depression, Adolescent Health
Reducing Health Risk Behavior and Improving Health in Adolescents With Depression
This study will determine the effectiveness of a health education intervention in reducing health risk behavior and improving health in adolescents with depression.
- Trial name
- NCT00461539
- Testing
- Treatment as usual, Behavioral health intervention
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- University of California, Los Angeles
CRAFT, Concern Significant Others
Community Reinforcement and Family Training (CRAFT)
The present study is dedicated to empowering individuals close to an addicted person (i.e. concerned significant others, CSOs) to create changes in their family environment: changes that increase the likelihood of the addicted…
- Conditions
- CRAFT, Concern Significant Others, Alcohol Use Disorder
- Trial name
- CRAFT (NCT03281057)
- Testing
- CRAFT
- Where
- 2 sites in Denmark
- Volunteers
- 255 people
- Sponsor
- Kjeld Andersen
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse
Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments
The investigators developed the Kisoboka ("It is possible") Intervention to address limitations of existing evidence-based interventions to optimize treatment as prevention among men living with HIV who drink alcohol at hazardous…
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse, HIV Infection, Alcohol Use Disorder
- Trial name
- Kisoboka (NCT06771843)
- Testing
- Kisoboka, Behavioral Economics, Motivational Interviewing
- Where
- Uganda
- Volunteers
- 716 people
- Sponsor
- San Diego State University
Depressive Disorder, Anxiety Disorder
Collaborative and Stepped Care in Mental Health (COMET)
The aims of COMET are the implementation and evaluation of effectiveness and cost-effectiveness as well as processes of a collaborative and stepped care model for depressive, anxiety, somatoform and/or alcohol abuse disorders…
- Conditions
- Depressive Disorder, Anxiety Disorder, Somatoform Disorder, Alcohol Use Disorder
- Trial name
- COMET (NCT03226743)
- Testing
- collaborative and stepped care model
- Where
- Germany
- Volunteers
- 615 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Bipolar Disorder, Alcohol Use Disorder
Ondansetron for Bipolar Disorder and Alcohol Use Disorders
The purpose of the study is to determine if ondansetron, as an add-on therapy, is associated with reduced depressive symptoms and alcohol use in outpatients with bipolar disorder (BPD), cyclothymic disorder, schizoaffective…
- Conditions
- Bipolar Disorder, Alcohol Use Disorder, Dual Diagnosis
- Trial name
- NCT02082678
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Texas Southwestern Medical Center
Tremor
Effect of Alcohol on Tremors
Tremors are involuntary movements of a part or parts of the body that occur because of alternating contraction and relaxation of muscles. The causes behind most tremors are poorly understood.
- Trial name
- NCT00001925
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Fetal Alcohol Spectrum Disorders
Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention
This study on children with fetal alcohol spectrum disorder (FASD) aims to (i) characterize their self-regulation deficits, a process important for controlling emotions and behavior, (ii) describe brain structure and function…
- Trial name
- NCT02457676
- Testing
- Alert Program for Self-Regulation
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Alcohol-Related Disorders, Cocaine-Related Disorders
Disulfiram for Cocaine-Alcohol Abuse - 3
The purpose of this study is to evaluate disulfiram for cocaine-alcohol abuse.
- Trial name
- NCT00000278
- Testing
- Disulfiram
- Where
- United States
- Sponsor
- Yale University
Alcohol Dependence
Ambivalence Model of Craving: Re-examining the Drinking-craving Relationship
The current study combines both clinical trial and daily process methodology to examine the dynamic longitudinal relationships between daily approach and avoidance inclinations (i.e., craving) and drinking behaviors in those…
- Trial name
- NCT01883089
- Testing
- Motivational Enhancement Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Binge Drinking, Alcohol Drinking
Alcohol Consumption: Norms, Identities, & Motivations
The emergence of new problematic alcohol consumption practices among young people requires new dynamics in prevention strategies.
- Trial name
- ALCONIM (NCT06447350)
- Testing
- Induced hypocrisy, social identity mapping, Motivational modeling
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Musculoskeletal Pain, Osteoarthritis
Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas.
This study aims to compare the effects of an in-person physiotherapist-led lifestyle-focused pain care intervention with a virtual multidisciplinary lifestyle-focused pain care intervention on pain impact in people with…
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Low Back Pain
- Trial name
- HeLP-R (NCT07173335)
- Testing
- In-person physiotherapist led integrated healthy lifestyle and pain care, Virtual multidisciplinary integrated healthy lifestyle and pain care
- Where
- 3 sites in Australia
- Volunteers
- 354 people
- Sponsor
- University of Sydney
Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD), Hepatomegaly
Gepaktiv vs UDCA and Ademetionine in MAFLD With Hepatomegaly
This study compares the effectiveness of the dietary supplement Gepaktiv with standard medications (UDCA and Ademetionine) in patients with fatty liver disease (MAFLD) and liver enlargement (hepatomegaly).
- Conditions
- Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD), Hepatomegaly, Nonalcoholic Fatty Liver (NAFL), Nonalcoholic Fatty Liver Disease (NAFLD)
- Trial name
- HEPACT (NCT07068191)
- Testing
- Dietary supplement "Gepaktiv", UDCA (Ursodeoxycholic acid), Ademetionine
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Phenomen Pharma
Frailty, Vision and Hearing Loss
Health Determinants in Older Adults Living At Home
The observational study will conduct interprofessional assessments by registered nurses, physiotherapists, and occupational therapists of health determinants (i.e., frailty, physical, cognitive, and sensory function, mental and…
- Conditions
- Frailty, Vision and Hearing Loss, Cognitive Function, Social 1, Mental Health Issue
- Trial name
- NCT05837728
- Testing
- Health promoting assessment of older adults living at home
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Stavanger
Alcoholic Hepatitis
Effect of Saturated Fat (Desi Ghee) on Gut-Liver Axis in Alcoholic Hepatitis
The pathogenesis of the alcoholic liver disease (ALD) is a complex interplay of various etiopathological factors other than direct alcohol toxicity.
- Trial name
- SFAH (NCT04084522)
- Testing
- Saturated Fat- Desi Ghee (Clarified Butter), Soyabean Oil
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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