Clinical trials: Alcohol Disorders
Alcoholism
Trial for the Treatment of Alcohol Dependence
The purpose of this study is to compare the effectiveness of two anti-craving medications, naltrexone versus acamprosate, in the treatment of alcohol dependence.
- Trial name
- NCT00120601
- Testing
- Naltrexone, Acamprosate
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- University of Sydney
Alcohol Use Disorder (AUD), Alcohol Abuse
Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder
Background: Alcohol Use Disorder (AUD) is a complex psychiatric disorder, involving several brain areas and neurocircuits. Transcranial Direct Current Stimulation (tDCS) allows to stimulate superficial areas of brain using a weak…
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- NCT04897295
- Testing
- Active transcranial Direct Current Stimulation
- Volunteers
- 30 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD)
Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training on the treatment of individuals with alcohol use…
- Conditions
- Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD), Alcoholism
- Trial name
- Nektar (NCT06969937)
- Testing
- Ketamine, Real-time fMRI Neurofeedback Training
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Dr. med. Marcus Herdener
Alcoholism
Use of Naltrexone in a Clinical Setting
This 12-week trial will compare individuals receiving naltrexone or placebo plus substance abuse counseling therapy versus those receiving only substance abuse counseling therapy in a rural, nonacademic setting.
- Trial name
- NCT00000445
- Testing
- naltrexone (Revia)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholism, Alcohol Drinking
Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for…
- Conditions
- Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders
- Trial name
- NCT04934553
- Testing
- Amplification of Positivity Training, Cognitive-behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Charles Taylor
Substance-related Disorders, Depression
Primary Care iSBIRT to Reduce Serious Teen Health Risks
The goal of the project is to develop and test an internet/intranet-based Screening, Brief Intervention, and Referral to Treatment (iSBIRT) system for adolescents that targets a broad range of serious health-risks and problem…
- Conditions
- Substance-related Disorders, Depression, High-risk Sex
- Trial name
- NCT00891631
- Testing
- iSBIRT, iSBIRT/TE
- Where
- United States
- Sponsor
- Boston Children's Hospital
HIV, Substance Use Disorders
The Collaborative Care PrTNER Study
A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk…
- Conditions
- HIV, Substance Use Disorders, Substance Use, AIDS
- Trial name
- PrTNER (NCT06585631)
- Testing
- CC PrTNER
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Alcohol Use Disorder, Severe
Impact of Omega 3 in Alcohol Use Disorder
The goal of this clinical trial is to investigate the biological pathways underlying the beneficial effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on mental health in patients with alcohol use disorder.
- Trial name
- W3-AUD (NCT05899660)
- Testing
- Active Comparator: Omega-3
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Depression, Problem Drinking
Brief Internet Intervention for Hazardous Alcohol Use to People Seeking Online Help for Depression
Hazardous alcohol consumption is common among people suffering from depression. There are effective Internet interventions that target hazardous alcohol consumption or depression separately but none that combine these online…
- Trial name
- NCT03421080
- Testing
- MoodGYM, Check Your Drinking
- Where
- Canada
- Volunteers
- 988 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking, Nicotine Dependence
Alcohol Counseling for Telephone Quitline Callers
The goal of this study is to train phone counselors working for the New York (NY) State Smokers' Quitline to advise callers who drink at hazardous levels to limit or abstain from alcohol use to determine whether this improves…
- Conditions
- Smoking, Nicotine Dependence, Alcohol Dependence
- Trial name
- NCT01120080
- Testing
- Practical Counseling, Alcohol Intervention Counseling
- Where
- United States
- Volunteers
- 1,948 people
- Sponsor
- Yale University
Alcohol Use Disorder
Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder
Alcohol activates reward systems in different brain areas, i.e., the nucleus accumbens, dorsal striatum, extended amygdala, and prefrontal cortex.
- Trial name
- NCT06866379
- Testing
- Brain imaging
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Opioid-use Disorder, Harmful; Use, Alcohol
Patient Driven Recovery With Nalmefene and Coaching
In collaboration with the First Pavlov State Medical University in St. Petersburg, Russia, we are proposing a pilot, open label, non-randomized clinical trial to evaluate the safety, feasibility, acceptability, and preliminary…
- Trial name
- NCT03279562
- Testing
- Nalmefene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Alcohol-induced Brain Injury
Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury
Alcohol is one of most common harmful substance, and alcohol intake brings great burden on health worldwide. Excess alcohol intake may lead to alcohol-related brain injuries and cognitive impairment.
- Trial name
- NCT03968042
- Testing
- Nerve Growth Factor, Edaravone, Combination of vitamin B1, B6, C, E and mecobalamine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Alcohol Use Disorder
The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers
A double-blind, randomized, placebo-controlled, crossover design trial was used to test the effect of exenatide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03645408
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Alcoholic Hepatitis, Alcohol-related Liver Disease
Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease
This is a study to measure liver recovery in patients with recent alcohol-associated liver injury by assessing liver function and physiology using HepQuant DuO.
- Trial name
- NCT07060547
- Testing
- HepQuant DuO Test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- HepQuant, LLC
Fetal Alcohol Spectrum Disorder
Parenting Training for Children With FASD
Prenatal alcohol exposure can lead to a myriad of adverse developmental outcomes in children, and is the leading cause of mental disability in Canada.
- Trial name
- SF-FASD (NCT02210455)
- Testing
- Strongest Families FASD intervention, Psychoeducation
- Where
- Canada
- Volunteers
- 119 people
- Sponsor
- IWK Health Centre
Cannabis, Alcohol Drinking
Effects of THC and Alcohol on Driving Performance
Low blood concentrations of THC and alcohol appear to have a minimal effect on driving performance.However, there is a gap in the literature about the combined effects of THC and alcohol.
- Conditions
- Cannabis, Alcohol Drinking, Accident, Traffic
- Trial name
- NCT03555968
- Testing
- THC 0, THC 5, THC 10
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lakehead University
NAFLD, Alcoholic Hepatitis
EUS Guided Liver Biopsy - Will it Give Better Yield, More Tissue With Less Complication?
Liver biopsy would be done by Endoscopic Ultrasound using Acquire needle.
- Trial name
- NCT04235855
- Testing
- Endoscopic USG guided Liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Alcohol Use Disorder (AUD)
Combining a Smartphone App With Medications to Manage Heavy Drinking
One in 10 Veterans have an alcohol use disorder. However, few Veterans receive evidenced-based psychosocial interventions or medications to treat alcohol use disorder.
- Trial name
- NCT06303778
- Testing
- Stand Down mobile app, Standard Care
- Where
- 15 sites in United States
- Volunteers
- 330 people
- Sponsor
- VA Office of Research and Development
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