Clinical trials: Alcohol Disorders
Major Depressive Disorder, Alcohol Use Disorder
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
The purpose of this study is to determine whether psilocybin, a hallucinogenic drug, is effective in reducing depressive symptoms and amount of drinking in patients with co-occurring Major Depressive Disorder (MDD) and Alcohol…
- Trial name
- PsiloMDDAUD (NCT04620759)
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder…
- Trial name
- Mu Kappa (NCT05957159)
- Testing
- Detoxification Program, PKAB, CFN
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder
Alcohol activates reward systems in different brain areas, i.e., the nucleus accumbens, dorsal striatum, extended amygdala, and prefrontal cortex.
- Trial name
- NCT06866379
- Testing
- Brain imaging
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Alcoholism
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
This study will evaluate a safe and useful medication for outpatient detoxification that is as effective as benzodiazepines in the short-term, and more effective in the protracted withdrawal period.
- Trial name
- NCT00011297
- Testing
- gabapentin (Neurontin), lorazepam (Ativan)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
HIV-1-infection, Alcohol Drinking
Acute Neural and Immune Effects of Alcohol in People Living With HIV Infection
This study will examine whether moderate alcohol use in the context of HIV infection exacerbates inflammatory signaling in the immune system and brain.
- Trial name
- NCT04050735
- Testing
- Alcohol, ethyl, moderate dose
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Brown University
Chemically-Induced Disorders, Substance-Related Disorders
Study of Structural Imaging
Background: The way alcohol affects brain structure has been widely studied. But the way it affects all parts of the brain is still unknown.
- Conditions
- Chemically-Induced Disorders, Substance-Related Disorders, Mental Disorders, Alcohol Dependence
- Trial name
- NCT02564991
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
AODD and AODR Disorder
The Efficacy of Brief Motivational Interviewing for Trauma Patients Related to Alcohol or Other Abuse Drugs.
The purpose of this study is to determine whether the Brief Motivational Interview will produce a significantly reduction in risk behavior than usual treatment 3 months after discharge from hospital in people who have survived a…
- Trial name
- MOTIVA (NCT02159391)
- Testing
- Brief Motivational Interview
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Substance Abuse
Impact of Personalized Feedback Alone on Substance Use Behaviors
The investigators seek to develop a more efficient and effective approach to providing brief behavioral health interventions for risky substance use behaviors by comparing a brief coach directed intervention to a tailored report…
- Trial name
- NCT01501318
- Testing
- Personalized feedback report, Personalized feedback report plus education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Endometrioma, Fertility Disorders
Anti-mullerian Hormone (AMH) After Treatment of Endometriomas With Alcohol Sclerotherapy Versus Surgery: Clinical Trial
The purpose of this multicenter study is to compare the ovarian reserve after alcohol sclerosis of the endometriomas against conventional surgery (AMH, follicle stimulating hormone (FSH) and antral follicles count) as well as the…
- Trial name
- NCT03571776
- Testing
- Surgery, Sclerotherapy
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Hospital Universitari de Bellvitge
Alcoholism
Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study
Background: Alcohol use disorder (AUD) affects about 10 percent of people in the U.S. Studies show a relationship between the bacteria (microbiota) in the gut and the brain. Researchers think this may influence AUD.
- Trial name
- NCT03152760
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drinking, Alcohol
A Targeted, Real-Time, Technology-Supported Intervention for Patients With Alcohol Use Disorder on Disulfiram
Alcohol use disorders (AUDs) are a costly and burdensome health concern, affecting over 15 million adults each year in the United States.
- Trial name
- Wisepill+SMS (NCT03543735)
- Testing
- Wisepill+SMS, Wisepill-only
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Butler Hospital
Severe Alcoholic Hepatitis
A Comparison of Fecal Microbiota Transplantation and Steroid Therapy in Patients With Severe Alcoholic Hepatitis.
Study population: Patients attending the Out Patient Department and admitted to Institute of Liver and Biliary Sciences. Study design: Prospective randomized controlled trial Study period: One year- January 2017- December 2018…
- Trial name
- NCT03091010
- Testing
- Fecal Microbiota Transplantation, Steroids
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol-related Disorders, Alcohol Drinking
Alcohol Expert System Intervention for Problematic Alcohol Use
In a randomized controlled trial, patients recruited in a general hospital and fulfilling criteria for alcohol dependence, alcohol abuse or at-risk drinking will be randomly allocated to two conditions:(1) Transtheoretical Model…
- Trial name
- NCT00400010
- Testing
- Expert System Intervention
- Where
- Germany
- Volunteers
- 347 people
- Sponsor
- University of Luebeck
Lysosomal Acid Lipase Deficiency, Wolman Disease
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency
This was an open-label, repeat-dose, intra-participant dose-escalation study of SBC-102 (sebelipase alfa) in children with growth failure due to lysosomal acid lipase (LAL) Deficiency.
- Trial name
- NCT01371825
- Testing
- Sebelipase alfa (SBC-102)
- Where
- 7 sites in United States, Egypt and 3 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Cannabis, Alcohol Effect
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II
The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
- Conditions
- Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
- Trial name
- THC-ETOH-II (NCT02710097)
- Testing
- Active inhaled cannabis, Active Oral Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder (AUD)
eTSF for Latinx Young Adults With Alcohol Use Disorder
The goal of this clinical trial is to learn if the eTSF intervention is feasible among Latinx young adults with alcohol use disorder.
- Trial name
- NCT06722690
- Testing
- eTSF, Educational materials
- Volunteers
- 40 people
- Sponsor
- Tulane University
Binge Drinking
Cognitive Retraining and Brain Stimulation for Alcohol Use
The overarching goal of this study is to determine whether combined cognitive training and Transcranial Direct Current Stimulation (tDCS) reduces drinking in high-risk drinkers.
- Trial name
- NCT02045108
- Testing
- Active Retraining, Active TDCS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- The Mind Research Network
Motivational Interviewing, Alcohol Use Disorder
ClientBot: a Conversational Agent That Supports Skills Practice and Feedback for Motivational Interviewing
This multi-stage study includes qualitative interviews, usability research, and a randomized training study of technology implementation in a real-world clinical setting.
- Trial name
- NCT05479890
- Testing
- ClientBot
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Lyssn.io, Inc.
Alcohol Withdrawal
Remote Treatment of Alcohol Withdrawal
This study will evaluate the feasibility of delivering symptom-triggered alcohol withdrawal management by telemedicine and determine whether this intervention is satisfactory to patients.
- Trial name
- NCT04858490
- Testing
- Diazepam
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
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