Clinical trials: Alcohol Disorders
Alcohol Use Disorder, Mild Cognitive Impairment
The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder
This is an open label feasibility trial to learn whether the combination of donepezil and cognitive remediation therapy (Donepezil + CRT) may improve neurocognitive functioning and decreasing alcohol use in Veterans with alcohol…
- Trial name
- NCT04318639
- Testing
- Donepazil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Connecticut Healthcare System
Alcohol Related Disorders, Alcoholism
Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects
To monitor the inhibition of 5a-reductase (5AR) enzyme activity at 1, 3, 7, 14, 21, 28 and 42 days following administration of a single dose of dutasteride (2, 3, or 4 mg) by measuring the change in blood levels of…
- Conditions
- Alcohol Related Disorders, Alcoholism, Alcohol Abuse
- Trial name
- NCT00802321
- Testing
- Dutasteride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UConn Health
Heavy Drinking, HIV
Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers
Heavy drinking (HD) is a risk factor for HIV transmission and is more common in HIV+ individuals than in the general population.
- Conditions
- Heavy Drinking, HIV, Alcohol Dependence
- Trial name
- NCT01764685
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pennsylvania
Alcoholism, Attention Deficit Disorder With Hyperactivity
ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse
Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence.
- Trial name
- AGADIR (NCT02364817)
- Testing
- cognitive and psychiatric assessment
- Where
- 3 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Lille
Borderline Personality Disorder, Alcohol Use Disorder
Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder
The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.
- Trial name
- NCT00145678
- Testing
- Psychodynamic Therapy, Optimized Community Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alcoholism, Substance-related Disorders
Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services
Homeless Veterans with substance use disorders (SUDs) are a major group served by VA and are heavily represented in VA housing. VA recently adopted a 'Housing First' approach emphasizing rapid housing placement to initiate…
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- NCT02233738
- Testing
- Group Motivational Interviewing (GMI), Control Treatment Condition (CT)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- VA Office of Research and Development
Self-Efficacy, Health Literacy
Health Literacy and Self-efficacy Expectations in Patients With Alcohol-related Liver Cirrhosis
The goal of this observational study is to quantify the health literacy and self-efficacy in people with alcohol-related liver cirrhosis.
- Conditions
- Self-Efficacy, Health Literacy, Liver Cirrhosis, ALD - Alcoholic Liver Disease
- Trial name
- GESA (NCT07169526)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Risk for an Alcohol-Exposed Pregnancy, Hazardous Alcohol Use
Project CHOICES Efficacy Study
Project CHOICES Efficacy Study is a randomized controlled trial (RCT) designed to evaluate the clinical efficacy of a brief motivational intervention aimed at reducing alcohol-exposed pregnancies(AEP)in high-risk preconceptional…
- Conditions
- Risk for an Alcohol-Exposed Pregnancy, Hazardous Alcohol Use, Risk for Unintended Pregnancy
- Trial name
- NCT00153478
- Testing
- Brief Motivational Counseling
- Where
- 11 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- Centers for Disease Control and Prevention
Alcoholism, Substance-related Disorders
CRP and S&A for Inpatient Veterans
The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems.
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- CRP and S&A (NCT05054738)
- Testing
- Combined Recovery Program, Stable & Able (S&A)
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders
Adaptive Treatment for Alcohol and Cocaine Dependence
1. Primary objective #1: Determine the relative effectiveness of MI-IOP and MI-PC in the full study sample with regard to treatment engagement over weeks 1-12 and cocaine/alcohol use over weeks 1-24.
- Trial name
- NCT01032135
- Testing
- Motivational Interviewing, Telephone counseling, Cognitive Behavioral Therapy (CBT) Counseling
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Pennsylvania
Glaucoma Open-Angle
Social History and Glaucoma Progression
The objective of this study is to predict of glaucoma progression. By imaging of the retinal nerve fiber layer RNFL, optic nerve head (ONH) and macular measurements using spectral-domain OCT (SD-OCT) instruments
- Trial name
- OCT (NCT06434155)
- Where
- Egypt
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Assiut University
Substance Use, Binge Drinking
Substance Use Screening to Encourage Behavior Change Among Young People in Primary Care
This study evaluates whether completing a short screening questionnaire about health behaviours in the waiting room before a primary care consultation decreases excessive substance use in young people aged 14 to 24 years.
- Conditions
- Substance Use, Binge Drinking, Cannabis Use, Adolescent Behavior
- Trial name
- YP-HEALTH (NCT04146714)
- Testing
- Substance use questionnaire, Physical activity questionnaire
- Where
- Switzerland
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Prof. Dagmar M. Haller
Alcoholic Cirrhosis
EUS Based Prevalence of Chronic Pancreatitis in Alcoholic Cirrhosis
Alcohol is the common precipitating factor for both cirrhosis of liver as well as alcohol related chronic pancreatitis. However, in real life clinical setting, clinicians do not frequently see many cases of symptomatic…
- Trial name
- NCT04245189
- Testing
- Endoscopic ultrasound for detection of Chronic pancreatitis
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Alcoholism
Overcoming Addictions: A Randomized Clinical Trial of a Web Application Based on SMART Recovery
The objective of this research project is to develop, evaluate, and disseminate an Internet-based (web) application for SMART Recovery: Overcoming Addictions (OA).
- Trial name
- NCT01389297
- Testing
- SMART Recovery face-to-face meetings, Overcoming Addictions web application
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Behavior Therapy Associates, LLP
Alcoholic Hepatitis
Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid
Steroid is the treatment of choice in patients with severe alcoholic hepatitis. However, null- or partial responder of steroid treatment is recommended to consider liver transplantation.
- Trial name
- GraCiAH (NCT02442180)
- Testing
- G-CSF (Filgrastim injection), steroid
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Chuncheon Sacred Heart Hospital
ICU Patients Requiring a Central Venous Access
Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions.
- Trial name
- NCT00259350
- Testing
- Skin disinfection
- Where
- France
- Volunteers
- 520 people
- Sponsor
- Poitiers University Hospital
Alcohol-Related Disorders, Marijuana Abuse
Substance Dependent Teens - Impact of Treating Depression Study 1 - 1
The purpose of this study is to evaluate the impact of treating depression on substance dependent teens.
- Conditions
- Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
- Trial name
- NCT00061113
- Testing
- Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Abuse
Puerarin Effects on Alcohol Drinking
This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking.
- Trial name
- PAD (NCT00854724)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Abuse
Benefit of Carbohydrate Deficient Transferrin to Detect Chronic Alcohol Abuse in the Elderly
Alcohol misuse affects 5 million people in France. Even though the elderly are also concerned by this pathology, there is not much information about chronic alcohol misuse of this population in particular.
- Trial name
- Caesar (NCT02822911)
- Testing
- Alcohol Used Disorders Identification Test (AUDIT C), Carbohydrate deficient transferrin, Gamma glutamyl transpeptidase
- Where
- 2 sites in France
- Volunteers
- 194 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Alcoholism
Naltrexone Maintenance Treatment of Alcoholism
The purpose of this study is to determine the long-term effectiveness of naltrexone treatment in alcohol-dependent patients who respond to short-term treatment.
- Trial name
- NCT00000450
- Testing
- Naltrexone Tablet
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- The Scripps Research Institute
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