Clinical trials: Alcohol Disorders
Marijuana Usage, Alcohol Drinking
Neuroscience of Alcohol and Marijuana Impaired Driving
Alcohol is one of the most widely used intoxicants. The effects of driving while intoxicated are well documented, leading to the laws and regulations behind drunk driving.
- Trial name
- NCT03431987
- Testing
- One day with a dose of active THC cannabis paired with alcohol
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Alcohol Withdrawal, Alcohol Use Disorder
Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal
The purpose of this study is to see if stimulation of the vagus nerve via a non-invasive device placed behind external ear can reduce physical and psychological discomfort during acute alcohol withdrawal in patients with alcohol…
- Trial name
- NCT04159909
- Testing
- Transcutaneous Nerve Stimulation
- Where
- United States
- Sponsor
- Northwell Health
Alcoholism
Chicago Social Drinking Project
This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by: 1.
- Trial name
- CSDP (NCT00961792)
- Testing
- Ethanol, Diphenhydramine, Caffeine
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Severe Alcohol Use Disorder (DSM 5)
Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH
Randomized clinical trial of 11 days Cannabidiol versus placebo as an adjunctive treatment during inpatient alcohol detoxification to improve abstinence in patients with severe alcohol use disorder.
- Trial name
- CBD-OH (NCT05860699)
- Testing
- Half dose CBD, Full dose CBD
- Where
- 12 sites in France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Use Disorder
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder.
- Trial name
- NCT04098302
- Testing
- Dutasteride Capsules
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- UConn Health
Alcohol Use, Posttraumatic Stress Disorder
CBT vs. Supportive Texts for PTSD & Hazardous Drinking (Project Better Study 2)
The study aims to test the efficacy of a CBT-enhanced text message intervention and a supportive text message intervention to reduce symptom burden in individuals with post-traumatic stress disorder symptoms and co-occurring…
- Trial name
- NCT06648395
- Testing
- CBT Text Messages, Supportive Messages
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- University of Washington
Atrial Fibrillation (AF)
Alcohol as a Modifiable Risk Factor for Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, diagnosed in approximately 50 million people worldwide. Its prevalence is expected to increase, eventually affecting every third person, which will result in significant…
- Trial name
- AFFAIR (NCT07528729)
- Testing
- alcohol abstinence
- Volunteers
- 414 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tobacco Abstinence
Varenicline For Smokers In Recovery From Alcohol Dependence
The goal of this proposal is to explore the potential effectiveness of varenicline to treat tobacco dependence among recovering alcoholic smokers who, as a group, are at high risk for tobacco-caused morbidity and mortality.
- Trial name
- NCT01092702
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity
Effects of Alcohol After Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: gastric bypass, sleeve gastrectomy, and lap banding. The surgery is not part of the clinical trial.
- Trial name
- RBA (NCT01843257)
- Testing
- Alcohol challenge test Alcohol visit first
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcohol Dependence
Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism
The overarching aim of this trial is to evaluate naltrexone's efficacy in light of genetic variation and brain response to alcohol cues utilizing a neuroimaging paradigm. This trial has four specific aims.
- Trial name
- NCT00920829
- Testing
- Naltrexone 50 Mg
- Where
- 2 sites in United States
- Volunteers
- 358 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, HIV-infection/Aids
Development of an Intervention to Reduce Heavy Drinking and Improve HIV Care Engagement Among Fisherfolk in Uganda
Fisherfolk are a high risk population for HIV and are prioritized to receive antiretroviral treatment (ART) in Uganda, but risky alcohol use among fisherfolk is a barrier to HIV care engagement; multilevel factors influence…
- Trial name
- NCT03919695
- Testing
- Kisoboka: Behavioral and Structural Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- San Diego State University
Myopia, Astigmatism
Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol)
surgical correction of ametropia. A number of improvements have been introduced to overcome the side effects and complications such as corneal haze, epithelial irregularities induced by wound healing, pain and delayed visual…
- Trial name
- H-TransPKR (NCT05072977)
- Testing
- TransPRK, Alcohol PRK
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Alcohol Consumption, Alcohol Intoxication
A Text Message Behavioral Intervention to Reduce Alcohol Consumption in Young Adults
Investigators aim to test the effectiveness of a text-message-based behaivoral intervention in reducing binge drinking among young adults.
- Trial name
- TRAC (NCT01688245)
- Testing
- SMS Assessments & Feedback, SMS Assessments
- Where
- United States
- Volunteers
- 765 people
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Harmful Alcohol Use
Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment
Many people who have risky alcohol use or alcohol dependence do not seek help, often is due to concerns about potential consequences or feelings of shame.
- Conditions
- Alcohol Abuse, Harmful Alcohol Use, Hazardous Alcohol Use, Hazardous Drinking
- Trial name
- NCT06675812
- Testing
- Information intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorder, Alcohol Abuse
Effectiveness of a WeChat-based Alcohol Consumption Intervention Mini-program ("Sober Time ACT") in China
The purpose of this study is to explore whether "Sober Time ACT", a digital intervention tool for alcohol use developed based on wechat mini program, is effective in improving risky alcohol use among Chinese local drinkers.
- Trial name
- NCT05827822
- Testing
- Sober Time ACT
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Dependence
Effects of Sulfasalazine on BOLD Response to Alcohol Cues
The overarching objective of this pilot study is to apply both neuroimaging and pharmacogenetic tools to the study of alcohol dependence.
- Trial name
- NCT01312129
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Mind Research Network
Alcoholism, Depression
Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism.
The aim of the present study was to examine the influence of memantine, a noncompetitive NMDA receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor, escitalopram.
- Trial name
- NCT00368862
- Testing
- Ebixa (memantine hydrochloride), Cipralex (escitalopram)
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Ventral Hernia, Surgery
STRONG for Surgery & Strong for Life - Intensive Prehabilitation for Risk Reduction in Ventral Hernia Repair
The five risky lifestyles Smoking, Nutrition (obesity and malnutrition), risky Alcohol intake, and Physical inactivity (SNAP) are common in surgical patients and associated with worse postoperative outcomes.
- Conditions
- Ventral Hernia, Surgery, Risk Reduction, Lifestyle
- Trial name
- STRONG-Hernia (NCT06611462)
- Testing
- Prehabilitation (the STRONG programme)
- Where
- 3 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Bispebjerg Hospital
Essential Tremor
Octanol to Treat Essential Tremor
This study will evaluate the effectiveness of 1-octanol, a substance similar to alcohol but less intoxicating, for treating essential tremor.
- Trial name
- NCT00080366
- Testing
- 1-Octanol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Fetal Alcohol Spectrum Disorders
Nutritional Risk Factors for FASD in Ukraine
Interventional study randomizing pregnant women at two sites in Ukraine who have or have not already consumed moderate to heavy levels of alcohol in pregnancy to receiving a standard prenatal vitamin supplement with or without…
- Trial name
- NCT03782935
- Testing
- Prenatal multivitamin mineral supplement
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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