Clinical trials: Alcohol Drinking
Alcohol Use Disorders, Stress Disorders, Posttraumatic
Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD
The purpose of the study is to evaluate if the drug prazosin: will decrease alcohol use in active duty members of the military who served in Iraq and/or Afghanistan and determine if presence or absence of posttraumatic stress…
- Conditions
- Alcohol Use Disorders, Stress Disorders, Posttraumatic, Combat Disorders
- Trial name
- NCT02226367
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Use Disorder, HIV/AIDS
Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV
Among patients with HIV, especially those also infected with HCV, heavy drinking is associated with significant risks to health.
- Conditions
- Alcohol Use Disorder, HIV/AIDS, Hepatitis C, Binge Drinking
- Trial name
- NCT03652675
- Testing
- Intervention: (Clinician's Guide + HealthCall for HIV/HCV)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Use, Drug Use
Alcohol Screening in an Ethnically Diverse Sample of Adolescents in Primary Care
Screening youth in the primary care setting is one way to identify adolescents who may be at-risk for future alcohol problems. The current study tests the new NIAAA screening guide questions, which ask about friend and adolescent…
- Trial name
- NCT01797835
- Testing
- CHAT brief MI intervention, usual care
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- RAND
Alcohol Abuse, Drug Abuse
Effects of Levetiracetam (Keppra) on Alcohol Consumption
The overall goals of this study are to (1) expand knowledge about interactions of levetiracetam with alcohol by assessing the effects of levetiracetam compared to placebo in moderate and heavy social alcohol users and (2) to test…
- Trial name
- NCT01168687
- Testing
- Levetiracetam (Keppra)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder, Couples
Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder
This project will develop and pilot test a new smartphone-based system for AUD patients, their partners, and clinicians called PartnerCHESS. PartnerCHESS will integrate key features of ABCT and A-CHESS.
- Conditions
- Alcohol Use Disorder, Couples, Behavior, Addictive
- Trial name
- NCT04059549
- Testing
- PartnerCHESS, A-CHESS
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Driving Drunk, Alcohol Drinking
Impacts of Subsidized Ridesharing on Drunk Driving, Alcohol Consumption, and Mobility
The purpose of this research study is to understand people's alcohol use in public places and their risks for harm. The overall goal of this study is to test the effects of subsidized ridesharing as an intervention to reduce…
- Trial name
- NCT04949711
- Testing
- ridesharing voucher, online shopping voucher
- Where
- United States
- Volunteers
- 7,034 people, healthy volunteers welcome
- Sponsor
- Columbia University
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Pancreatitis, Genetic Mutation
An Observational Study on the Natural Course of Chronic Pancreatitis
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
- Conditions
- Chronic Pancreatitis, Genetic Mutation, Smoking, Tobacco, Drinking, Alcohol
- Trial name
- NCT04574297
- Testing
- smoking and alcohol assumption, genetic sequencing
- Volunteers
- 798 people
- Sponsor
- Changhai Hospital
Alcohol Dependence
Aripiprazole Effects on Alcohol Drinking and Craving
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving and drinking compared to placebo depending on participant's baseline level of impulsivity.
- Trial name
- NCT01292057
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical University of South Carolina
Underage Alcohol Use
Alcohol Intervention for First Year College Students
While a large focus of research on U.S. college drinking has focused on the prevalence of and problems related to heavy-episodic drinking, less has focused on college students who are either abstainers or lighter drinkers (i.e.…
- Trial name
- NCT03750838
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Alcohol Use Disorder
Pilot Human Lab Study of Lacosamide in Alcohol Use Disorder (AUD)
The overall goal of the proposed project is to improve the treatment of individuals with AUD. The investigators will conduct the first pilot human laboratory study to assess the effects of two doses of lacosamide on alcohol…
- Trial name
- ACGT (NCT03897348)
- Testing
- Lacosamide 100 mg, Lacosamide 200 mg
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Insomnia, Alcohol Use Disorder
CBT-I on Alcohol Treatment Outcomes Among Veterans
Project SAVE aims to examine the feasibility, acceptability, and initial efficacy of a CBT-I supplement to alcohol treatment of Veterans.
- Trial name
- Project SAVE (NCT03806491)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene, Alcohol Use Disorder Treatment as Usual
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcohol Dependence, Alcohol Use Disorders
Mifepristone Treatment of Alcohol Use Disorder
This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up…
- Conditions
- Alcohol Dependence, Alcohol Use Disorders, Alcohol Abuse, Alcoholism
- Trial name
- NCT02179749
- Testing
- Mifepristone 1200 mg daily, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Scripps Research Institute
Youth Drinking, Alcohol Drinking
Alcohol Feedback, Reflection and Morning Evaluation
The investigators propose to examine mornings after drinking as an optimal time to provide repeated, personalized feedback, with the goal of reducing hazardous drinking.
- Trial name
- (A-FRAME) (NCT05509218)
- Testing
- Mobile-delivered personalized feedback
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder (AUD), Transcranial Magnetic Stimulation
Examining the Effectiveness of Deep TMS in Veterans With Alcohol Use Disorder
This study aims to evaluate the efficacy of deep transcranial magnetic stimulation (dTMS) as a treatment for Veterans with an alcohol use disorder (AUD).
- Trial name
- NCT04927364
- Testing
- Deep Transcranial Magnetic Stimulation (dTMS) H7 coil
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Palo Alto Health Care System
Alcohol Drinking
Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors
The primary purpose of the study is to increase our knowledge of receptor function in the brains of people who are heavy drinkers and taking naltrexone (NTX), a medication that has been approved for the treatment of alcohol…
- Trial name
- NCT01625611
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Yale University
Human Immunodeficiency Virus, STI
A Savings Intervention to Reduce Men's Engagement in HIV Risk Behaviors
This randomized control trial will test an economic intervention to reduce Kenyan men's engagement in behaviors that increase the risk of HIV/STIs.
- Conditions
- Human Immunodeficiency Virus, STI, Alcohol Consumption, Incentives
- Trial name
- NCT05385484
- Testing
- Receives mobile banking account with incentives to save, Basic Health and financial education
- Where
- Kenya
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Drinking, Telemedicine
Mobile Health for Alcohol Use Disorders in Clinical Practice
This study evaluates the impact on risky drinking days and quality of life for patients with alcohol use disorder among patients who use a mobile health smart phone application.
- Trial name
- NCT04011644
- Testing
- A-CHESS self-monitored, A-CHESS peer-supported, A-CHESS clinically-integrated
- Where
- United States
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison