Clinical trials: Alcohol Use Disorder, Moderate
Alcohol Use Disorder
Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder
The purpose of this study is to evaluate the efficacy of sunobinop compared to placebo on alcohol consumption in subjects with alcohol use disorder.
- Trial name
- NCT06545916
- Testing
- Sunobinop
- Where
- 7 sites in United States, Romania
- Volunteers
- 209 people
- Sponsor
- Knoa Pharma LLC
Alcohol Use Disorder, Alcohol Use, Unspecified
Drinking, Acetate, and Stress
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry.
- Conditions
- Alcohol Use Disorder, Alcohol Use, Unspecified, Heavy Drinker, Alcohol Use Disorder, Moderate, in Sustained Remission
- Trial name
- NCT06584448
- Testing
- Deuterium Metabolic Imaging with deuterated acetate tracer
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Addiction, Alcohol
Impact of a Brief Motivational Intervention Including Counter-marketing Arguments With a Population of Patients With Moderate to Severe Alcohol Use Disorders Who Are Followed up on an Outpatient Basis (Primary Care or Addictology) (DEPREV_Phase 3)
Alcohol consumption is the second cause of avoidable death after tobacco. The Evin law was constructed in 1991 with the aim of reducing exposure to alcohol marketing among the youngest.
- Trial name
- NCT04881500
- Testing
- Motivational interview, Routine Care
- Where
- 6 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Alcohol Use Disorder
Oxytocin on Approach Bias and Craving
This will be a laboratory-based investigation of the behavioral and neural effects of intranasal oxytocin on craving for alcohol and approach bias in moderate to heavy alcohol using subjects.
- Trial name
- NCT03865615
- Testing
- Oxytocin
- Where
- United States
- Sponsor
- Jennifer Mitchell
Alcohol Use Disorder
ED Initiated Oral Naltrexone for AUD
This study will recruit Emergency Department (ED) patients with moderate to severe alcohol use disorder (AUD) who are interested in initiating medication assisted treatment (MAT). The study is split into two phases.
- Trial name
- NCT04817410
- Testing
- Emergency Department Initiated Oral Naltrexone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Use Disorder
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use Disorder (AUD). Participation in this study will last approximately 56 weeks.
- Trial name
- RENEW-ALC-1 (NCT07219966)
- Testing
- LY3537031
- Where
- 117 sites in United States, Belgium and 6 more
- Volunteers
- 1,100 people
- Sponsor
- Eli Lilly and Company
Alcohol Use Disorder
Oxytocin Treatment for Alcohol Use Disorders
To further test the effectiveness of oxytocin in heavy drinkers, half of the cohort in the proposed study will meet criteria for heavy drinking (>35 standard drinks/week [men], >28 standard drinks/week [women] for at least 4…
- Trial name
- OT-ETOH-4 (NCT03636555)
- Testing
- Oxytocin
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Use Disorder, Mild, Alcohol Use Disorder, Moderate
Ultrabrief Behavioral Activation for Reducing Alcohol Use
This is a pilot study to assess feasibility, acceptability, and preliminary efficacy of a single-session ("ultrabrief") psychological intervention to reduce alcohol use in participants with mild to moderate alcohol use disorder…
- Trial name
- UBA (NCT05086172)
- Testing
- Ultrabrief Behavioral Activation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol-Related Disorders, Alcohol Use Disorders
Component Analysis for Motivational Interviewing
The purpose of this study is to investigate the critical components of motivational interviewing (MI), a psychotherapeutic intervention, in reducing heavy or problematic drinking.
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01642381
- Testing
- Full Motivational Interviewing ("FMI"), Spirit Only Motivational Interviewing ("SOMI")
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Northwell Health
Alcohol Use Disorder, Mild, Alcohol Use Disorder, Moderate
Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes
The goal of this clinical trial is to test whether a technology-substituted intervention (mhGAP-Remote) derived from the World Health Organization's (WHO) Mental Health Gap Action Programme-Intervention Guide (mhGAP-IG) is…
- Trial name
- NCT05925270
- Testing
- mhGAP-Remote, mhGAP-Standard
- Where
- 3 sites in Lesotho
- Volunteers
- 255 people
- Sponsor
- University Hospital, Basel, Switzerland
Alcohol Use Disorder, Mild-Moderate Traumatic Brain Injury
Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury
The project will examine the neural associations of alcohol approach-bias and investigate the extent to which a neuroscience-based personalized cognitive training program will remediate alcohol approach-bias and improve recovery…
- Trial name
- TABM (NCT06380985)
- Testing
- Personalized VR Alcohol Approach Bias Modification (ApBM) Condition
- Where
- United States
- Sponsor
- VA Office of Research and Development
Alcohol-Related Disorders, Alcohol Use Disorders
Tailored Mobile Text Messaging to Reduce Problem Drinking
This study is designed to develop and test a tailored adaptive text messaging/short message service (SMS) intervention for individuals interested in stopping or reducing their alcohol consumption; and test and compare it to…
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01885312
- Testing
- Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy, Alcohol Use Disorder (Mild vs. Moderate to Heavy)
Modification of Pavlovian and Instrumental Learning in Human Addiction
The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.
- Trial name
- NCT04032587
- Testing
- Modified training version of the Approach / Avoidance Task (AAT, see Wiers et al., 2011), Mindfulness-based interventions (e.g. body scan)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hepatic Fibrogenesis, Hepatitis C
Impact of Moderate Alcohol Use on Hepatitis C Virus (HCV) Progression
The purpose of this study is to determine the effect of moderate alcohol intake on liver disease caused by HCV in terms of speed of progression as compared to those not drinking alcohol.
- Trial name
- NCT00205075
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Wisconsin, Madison
Alcohol-Related Disorders, Alcohol Use Disorders
Messaging Interventions to Reduce Alcohol Problems Project
The study is designed to develop and test a tailored adaptive text messaging/short message service (SMS) intervention for individuals interested in reducing their alcohol consumption.
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- MIRAP (NCT03695653)
- Testing
- Drink Tracking (MA), Adaptive Tailored (TA), Tailored (TO)
- Where
- United States
- Volunteers
- 730 people
- Sponsor
- Partnership to End Addiction
Alcohol Abuse
Perception of the Risks of Alcohol and Individual Vulnerabilities in Young Adults
Alcohol use is the second leading cause of preventable death after smoking. The Evin law was built in 1991 with the goal of reducing exposure to alcohol marketing among the youngest.
- Trial name
- DEPREV (NCT03876132)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest
Substance Use Disorders
The Effects of an Acute Bout of Exercise on Alcohol and Cocaine Craving - an fNIRS Study
The study is a crossover randomised controlled trial. Alcohol or cocaine dependent participants will be recruited from inpatient and outpatient psychiatric treatment centres, on the approval of their treating physician.
- Trial name
- ExAlCo (NCT03502486)
- Testing
- Moderate exercise, Intense exercise, Reading
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Basel
Alcohol Use Disorder
Study of Sunobinop on Craving in Alcohol Use Disorder
The purpose of this study is to evaluate the efficacy of sunobinop compared to placebo on alcohol craving in subjects with moderate to severe alcohol use disorder and these subjects are seeking treatment.
- Trial name
- NCT06545929
- Testing
- Sunobinop
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Knoa Pharma LLC
Alcohol Abuse, Alcohol Use Disorder
Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
The primary aims of the study are to assess the user experience and initial efficacy of a mobile application designed to reduce problematic alcohol use.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Abuse, Episodic
- Trial name
- ALCMOD (NCT04286867)
- Testing
- Alcohol Moderation Mobile Application, Alcohol Moderation Drink Tracker
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kent State University