Clinical trials: Alcohol Use Disorders
Alcohol Use Disorder (AUD), Schizophrenia and Related Disorders
Dynamics of Risk Perception and Risk Behavior in Alcohol Use Disorder and Schizophrenia
The hyper- or hypo-attribution of risks is deeply related to the core pathological mechanisms of mental disorders and at the same time engaging in risky behaviors influences their course and outcomes.
- Trial name
- PathRisk (NCT04985786)
- Testing
- Cognitive Behavioral Therapy for reducing risk behaviors, Cognitive Behavioral Therapy for increasing non-risk behaviors
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Alcohol Use Disorder, Human Immunodeficiency Virus
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART).
- Trial name
- NCT06139224
- Testing
- 4 week prebiotic consumption
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Drug Use Disorders During Pregnancy
Reinforcement-Based Treatment for Pregnant Drug Abusers
Objectives: This project is a Stage II behavioral development study designed to answer remaining critical questions necessary before disseminating Reinforcement Based Treatment (RBT) to the larger treatment community.
- Trial name
- HOME II (NCT01177982)
- Testing
- Usual RBT (t-RBT), Reduced RBT (r-RBT), Abbreviated RBT (a-RBT)
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Environment and Alcohol: A Pilot Study
Background: Alcohol use disorder (AUD) is a chronic disease that causes more than 140,000 US deaths each year. AUD treatment often includes therapy and medication.
- Trial name
- NCT06860607
- Testing
- Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Alcohol Use Disorder
COVID-19-Related Opioid Treatment Policy Evaluation
Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT.
- Trial name
- COPE (NCT05028998)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Suicide, Alcohol Use Disorder
Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth
For the past 20+ years the investigators have focused on addressing two interrelated public health issues, alcohol use disorder (AUD) and suicide in Alaska.
- Trial name
- NCT05400135
- Testing
- Qungasvik (Tools for Life)
- Where
- United States
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Alcohol Use Disorder, PTSD
Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder
The project will examine whether a computerized neuroscience-based cognitive training program can improve cognitive functioning and recovery outcomes among Veterans with Alcohol Use Disorder and co-occurring PTSD.
- Conditions
- Alcohol Use Disorder, PTSD, Cognitive Dysfunction
- Trial name
- NCT02929979
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers
A double-blind, randomized, placebo-controlled, crossover design trial was used to test the effect of exenatide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03645408
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Substance Use Disorders, Overdose
Emergency Medicine Peer Outreach Worker Engagement for Recovery
This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART).
- Conditions
- Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
- Trial name
- EMPOWER (NCT06320015)
- Testing
- Substance Misuse Assistance Response Team (SMART), Usual Care Group
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Condomless Sex, Human Immunodeficiency Virus (HIV)
Cape Town Young Women's Health CoOp
This two-arm cluster randomized trial tested a gender-focused comprehensive HIV testing and counselling (HTC) program, the Young Women's Health CoOp (YWHC) with a standard HTC program and targeted female adolescents (aged 16-19)…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug Use
- Trial name
- NCT02974998
- Testing
- Young Women's Health CoOp (YWHC), Standard HTC
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Temporomandibular Joint Disorders
Acute Effects of Alcohol Use on Chronic Orofacial Pain
Self-medication of pain with alcohol is a common, yet risky, behavior among individuals with chronic orofacial pain. Chronic pain status may affect the degree to which alcohol use relieves pain, but the independent contributions…
- Trial name
- NCT04019093
- Testing
- Ethanol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Florida
Post Traumatic Stress Disorder, Alcohol Use Disorder
FAAH Availability in Psychiatric Disorders: A PET Study
The aim of the present study is to examine Fatty Acid Amide Hydrolase (FAAH) availability in humans, including healthy individuals and across a spectrum of psychiatric disorders in which alterations in the endocannabinoid system…
- Conditions
- Post Traumatic Stress Disorder, Alcohol Use Disorder, Psychosis
- Trial name
- NCT04404712
- Testing
- [11C]MK-3168
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder, Early Trauma Complications
Neurobiological Responses in Alcoholism and Early Trauma
Alcohol use disorder (AUD) accompanied by early trauma presents clinical challenges, including elevated rates of comorbid emotional symptoms and relapse.
- Trial name
- NCT04128228
- Testing
- 8-week outpatient treatment
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol; Liver
CM for Patients With ALD After Liver Transplant
Alcohol associated liver disease (ALD) refers to liver injury, such as cirrhosis, that is caused by alcohol use. It affects 2 million adults in the U.S.
- Conditions
- Alcohol Use Disorder, Alcohol; Liver, Post Liver Transplant, Contingency Management
- Trial name
- NCT06304467
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arpan A. Patel, MD
Support Persons, Family Members
Recovery Inspired Support Engagement (RISE) Pilot
The goal of this clinical trial is to learn if a 1-on-1 support program is easy to complete and acceptable for people supporting loved ones who have recently received treatment for substance use.
- Conditions
- Support Persons, Family Members, Chosen Family, Romantic Partners
- Trial name
- (RISE) (NCT07519759)
- Testing
- ITC
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Use Disorder
The Effects of Sex Hormones and Alcohol on Sleep
Rates of heavy drinking and Alcohol Use Disorder (AUD) are increasing in women, but research on alcohol-related harms in women - including alcohol's impact on sleep - has been minimal.
- Trial name
- NCT06143059
- Testing
- Ethanol, Saline
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ohio State University
College Drinking, Underage Drinking
Revolutionizing Normative Re-education
Personalized Normative Feedback (PNF), the most widely-used college alcohol intervention approach, suffers from several limitations innovatively remedied in the current proposal through CampusGANDR, a smartphone-based app for…
- Conditions
- College Drinking, Underage Drinking, Alcohol Use Disorder
- Trial name
- GANDR (NCT04356261)
- Testing
- Gamified Personalized Normative Feedback
- Where
- United States
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida