Clinical trials: Alcohol and Drug Use
Depression, Substance Use
Group CBT for Depression and AOD Disorders
The investigators will adapt and test an existing treatment (group CBT for depression) for use in outpatient substance use treatment settings as delivered by trained substance use counselors.
- Trial name
- BRIGHT2 (NCT01154309)
- Testing
- Group CBT for Depression and AOD Disorders
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- RAND
Alcohol Use, Cannabis Use
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer.
- Conditions
- Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use
- Trial name
- MATAspire (NCT06553196)
- Testing
- MATAspire Web-app
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
Primary Care Quality Metrics, Well Child Visits in First 15 Months of Life NQF 1392
The Impact of Patient Complexity on Healthcare Utilization
Healthcare providers are routinely being assessed for metrics designed to assess the quality of the care they deliver. There is growing consensus that these measurements, which typically assess the percentage of patients meeting…
- Conditions
- Primary Care Quality Metrics, Well Child Visits in First 15 Months of Life NQF 1392, Diabetes Mellitus NQF 0059, Colorectal Cancer Screening NQF 0034
- Trial name
- NCT03327896
- Testing
- Charlson score and Community Social Deprivation
- Volunteers
- 200,000 people
- Sponsor
- OCHIN, Inc.
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
This treatment intervention trial is designed for men and women with substance dependence and comorbid Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01365247
- Testing
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The City College of New York
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use
TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use Electronic Spanish Platform
This Phase 1 STTR project will develop a technology platform for delivering the TAPS Tool to a Spanish-speaking, health disparity population in a community health center.
- Trial name
- TASP-ESP (NCT03879785)
- Testing
- Screening
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
HIV, Alcohol Use
Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Alcohol use is increasingly recognized as a key factor in morbidity and mortality among HIV-positive individuals and represents an important public health concern, given its associations with medication non-adherence, increases…
- Conditions
- HIV, Alcohol Use, Medication Adherence
- Trial name
- PLUS (NCT02390908)
- Testing
- Immediate PLUS intervention, Wait-list PLUS intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Trauma, Alcohol Use, Unspecified
Secondary Prevention and Recidivism Reduction in Trauma Patients
The consumption of alcohol and other drugs is one of the main risk factors for traumatism. In addition, patients who have suffered an accident in relation to the consumption of these substances present a high risk of recidivism.
- Conditions
- Trauma, Alcohol Use, Unspecified, Drug Use
- Trial name
- NCT03967262
- Testing
- Brief Motivational Intervention
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Corporacion Parc Tauli
Healthy, Condom Use
Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth
We Are Here Now - Plus (NE+) is a holistic, culturally centered, and multilevel intervention for American Indian youth to improve sexual health, mental health, and substance use outcomes.
- Conditions
- Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol)
- Trial name
- NE+ (NCT07460973)
- Testing
- NE+, Control
- Where
- United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Montana State University
Alcohol Use Disorder
A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults
American emerging adults (EAs; aged 18-29 years) have the highest rates of alcohol use disorder (AUD) and the lowest levels of treatment engagement of any age group.
- Trial name
- NCT07214831
- Testing
- Large language model-based chatbot brief alcohol intervention session
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Alcoholism, Substance-Related Disorders
Study of Effectiveness of Adding the Health Promotion and Rehabilitation for Treatment for Alcohol and Drug Abusers
The purpose of this study is to evaluate the effect of adding the Health Promotion activities and rehabilitation to the usual alcohol and drug interventions on the outcome for alcohol and drug abusers compared to the usual…
- Conditions
- Alcoholism, Substance-Related Disorders, Smoking, Chronic Disease
- Trial name
- VIP (NCT01414907)
- Testing
- Health promotion activities
- Where
- Sweden
- Volunteers
- 214 people
- Sponsor
- Skane University Hospital
Alcohol-Related Disorders, Anxiety Disorders
Psychosocial and Medication Treatment for Anxiety in Alcoholism
The proposed project is written as a "typical clinical practice" test and is a fully-controlled trial of a combined anxiety-focused CBT and pharmacotherapy (venlafaxine; CBT-VEN) delivered for patients with comorbid alcohol-use…
- Trial name
- NCT00248612
- Testing
- Venlafaxine, CBT, Progressive muscle relaxation therapy (PMR)
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- Boston Medical Center
Relapse/Recurrence, Substance Use (Drugs, Alcohol)
Mindfulness-based Relapse Prevention for Peer Workers
Adapt and test the effectiveness of MBRP for substance use peer workers compared to a standard of care (referral to 12-step) control condition on substance use, relapse risk, and burnout among peers in a pilot hybrid type 1…
- Conditions
- Relapse/Recurrence, Substance Use (Drugs, Alcohol), Burnout
- Trial name
- MBRP (NCT07741825)
- Testing
- Mindfulness Based Relapse Prevention, Standard of Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas at Austin
Substance Abuse, Risk Reduction
First Years Away From Home: Letting Go and Staying Connected
Alcohol abuse is the leading cause of death and serious injury among college students, and students also experience significant harms from other types of substance misuse and risk behaviors.
- Conditions
- Substance Abuse, Risk Reduction, RIsky Sexual Behavior
- Trial name
- FYAH:LGSC (NCT03227809)
- Testing
- Handbook condition, Handbook plus condition
- Where
- United States
- Volunteers
- 910 people, healthy volunteers welcome
- Sponsor
- Washington State University
Posttraumatic Stress Disorder, Depression
Trauma Survivors Outcomes and Support Study IV
After traumatic injuries some people have difficulty returning to the routine of their everyday activities and may experience physical and emotional pain.
- Conditions
- Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury
- Trial name
- TSOS IV (NCT01625416)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Washington
Substance Use Disorders, Alcohol Use Disorder
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- IMPACT (NCT07232641)
- Where
- United States
- Volunteers
- 185,810 people
- Sponsor
- Boston University
Alcohol Use Disorder, Bipolar Disorder
Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders
Preclinical and clinical data as well as mechanistic justification have been presented suggesting citicoline and pregnenolone are each promising treatments for alcohol use in BPD.
- Conditions
- Alcohol Use Disorder, Bipolar Disorder, Schizoaffective Disorder Bipolar Type
- Trial name
- NCT02582905
- Testing
- Citicoline, Pregnenolone
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Sherwood Brown, MD, PhD
Substance Use Disorders
Implementation and Evaluation of SBIRT
Alarming rates of unhealthy alcohol, non-prescription drug, and tobacco use highlight the preventable health risks of substance abuse and the urgent need to advance behavioral health systems.
- Trial name
- NCT03560076
- Testing
- SBIRT Training and Implementation Strategies
- Where
- United States
- Volunteers
- 2,562 people
- Sponsor
- Indiana University
Drink Too Much, Drinking, Binge
Group-based Intervention for Club Patrons
The purpose of this study is to develop and test a group-based strategy for encouraging groups of young adults who are engaged in party behaviors at nightclubs to intervene with each other to reduce harms associated with overuse…
- Conditions
- Drink Too Much, Drinking, Binge, Drunk, Drug Use
- Trial name
- NCT03652688
- Testing
- Nightlife Safety Plans (NSP), Fire Safety
- Where
- 2 sites in United States
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation