Clinical trials: Alcohol-Related Liver Disease
Alcohol-Related Disorders
AlcoChange: An Open Label Pilot Study of Smartphone Monitoring for Alcoholic Liver Disease
Alcohol contributes to over 5% of deaths worldwide, and death rates from alcohol-related liver disease (ARLD) in the UK continue to rise sharply.
- Trial name
- NCT03474328
- Testing
- AlcoChange
- Volunteers
- 60 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Acute-On-Chronic Liver Failure, Alcoholic Hepatitis
A-TANGO Phase 2 Study
The purpose of this research is to know if a new combination of drugs (TAK-242 and G-CSF) in combination with standard therapy for acute-on-chronic liver failure (ACLF) is more effective than standard therapy for ACLF treatment…
- Conditions
- Acute-On-Chronic Liver Failure, Alcoholic Hepatitis, Liver Cirrhosis, Alcoholic
- Trial name
- A-TANGO (NCT06890039)
- Testing
- TAK-242, G-CSF (Filgrastim)
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Yaqrit Ltd
Alcoholic Liver Disease, Liver Cirrhosis, Alcoholic
Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic Microbiota
Investigators wishes to influence the gut microbiota in patients with alcoholic liver disease in a randomized controlled clinical trial.
- Conditions
- Alcoholic Liver Disease, Liver Cirrhosis, Alcoholic, Probiotics, Liver Fibrosis
- Trial name
- SYN-ALD (NCT03863730)
- Testing
- Profermin Plus, FSMP, probiotics, Fresubin, dietary supplement
- Where
- 2 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Odense University Hospital
Liver Disease; Alcohol-Related, Gut Microbiota
Alterations of Gut Microbiota and Metabolites in ALD Patients
Alcohol-associated liver disease is one of the most prevalent liver diseases worldwide, and the leading cause of liver transplantation in the U.S.
- Trial name
- NCT05448144
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Alcohol-associated Liver Disease
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Alcohol Liver Disease
alcohol-associated liver disease (ALD) is a leading cause of cirrhosis, yet the role of gut microbiota-derived peptidoglycan (PG) metabolites in liver injury remains unclear.
- Trial name
- NCT07284862
- Testing
- An observational, non-interventional study design.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Alcohol Dependence
Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use
The purpose of this study is to explore the treatment effects of Selincro in alcohol dependent patients with liver impairment.
- Trial name
- NCT02197598
- Testing
- nalmefene
- Where
- 3 sites in Germany
- Volunteers
- 45 people
- Sponsor
- H. Lundbeck A/S
Severe Alcoholic Hepatitis
Rifaximin Use in Severe Alcoholic Hepatitis
This study aimed to investigate the effect of decontamination by rifaximin in severe alcoholic hepatitis patients. Patients who take corticosteroid or pentoxifylline will be randomly allocated to rifaximin group or control group.
- Trial name
- NCT02485106
- Testing
- Rifaximin, Corticosteroid or pentoxifylline
- Volunteers
- 170 people
- Sponsor
- Saint Vincent's Hospital, Korea
Alcoholic Liver Disease
Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis
Background/Aims: The investigators explored the therapeutic effects of probiotics in patients with AH. Methods: Between December 2012 and January 2015, the investigators conducted a 7-day, double-controlled, randomized…
- Trial name
- NCT02335632
- Testing
- Probiotics (Lacidofil®)
- Volunteers
- 140 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Acute on Chronic Hepatic Failure, Acute Liver Failure
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
The study will evaluate the pharmacokinetics, pharmacodynamics, safety and preliminary efficacy of IDN-6556 in subjects with cirrhosis of the liver who are hospitalized for more than 24 hours due to acute deterioration of liver…
- Conditions
- Acute on Chronic Hepatic Failure, Acute Liver Failure, Liver Cirrhosis, Acute Alcoholic Hepatitis
- Trial name
- NCT01937130
- Testing
- IDN-6556
- Where
- 26 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Alcoholic Hepatitis, Infection
N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis
Recent data have suggested that monocyte oxidative burst defect is associated with the development of infection in patients with severe alcoholic hepatitis.
- Trial name
- NACAH (NCT03069300)
- Testing
- N-acetyl cysteine (NAC)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Steatotic Liver Disease, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study)
The rational to conduct the LOVE study builds on the lack of available data on outcomes in steatotic liver disease in well characterized patients over a time frame of several years.
- Conditions
- Steatotic Liver Disease, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Steatotic Liver Disease of Mixed Origin (MetALD), ALD - Alcoholic Liver Disease
- Trial name
- LOVE (NCT06907563)
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 30,000 people
- Sponsor
- Universität des Saarlandes
Alcoholic Hepatitis
IL-1 Signal Inhibition in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption.
- Trial name
- ISAIAH (NCT03775109)
- Testing
- Canakinumab 150mg/ml solution for injection
- Where
- 16 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Imperial College London
Alcoholic Hepatitis, Alcoholic Liver Disease
Meta-Analysis of Drug Therapy in Patients With Severe Alcoholic Hepatitis
In the specific setting of the evaluation of corticosteroids, pentoxifylline of their combination in severe alcoholic hepatitis, only meta-analysis combining individual data is able to provide detailed information from each…
- Trial name
- NCT02796469
- Testing
- Pentoxifylline, Corticosteroid
- Volunteers
- 1,974 people
- Sponsor
- University Hospital, Lille
Alcoholic Liver Disease, Alcohol Dependence
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
To explore the effectiveness and biobehavioural basis of baclofen in improving treatment outcomes for alcohol dependence in people with or without alcoholic cirrhosis in a double-blind randomised placebo-controlled trial.
- Trial name
- BacALD (NCT01711125)
- Testing
- Baclofen 30mg/day, Baclofen 75mg/day
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- South West Sydney Local Health District
Alcoholic Hepatitis, Alcoholic Cirrhosis
Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis
The study is aimed to evaluate the additional role of ciprofloxacin therapy in severe alcoholic hepatitis combined to prednisolone therapy in an open-label placebo controlled manner.
- Trial name
- NCT02326103
- Testing
- Ciprofloxacin
- Where
- Finland
- Volunteers
- 22 people
- Sponsor
- University of Helsinki
Alcoholic Hepatitis
Bovine Colostrum In The Treatment Of Severe Alcohol-Associated Hepatitis
Severe Alcohol-associated hepatitis, is associated with significant morbidity and mortality.1,2 Of the various treatment modalities evaluated for treatment of Severe Alcoholic hepatitis, corticosteroids have been the most…
- Trial name
- BASH (NCT07898761)
- Testing
- Bovine Colostrum Preparation
- Where
- India
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Dayanand Medical College and Hospital
Alcohol Use Disorder, Alcohol-associated Liver Disease
LGG Supplementation in Patients With AUD and ALD
To test the efficacy of 6-month LGG compared to placebo in treating Alcoholic Use Disorder (AUD) and liver injury in Alcoholic Hepatitis (AH).
- Trial name
- AUD+ALD (NCT05178069)
- Testing
- Lactobacillus Rhamnosus GG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Louisville
Alcoholic Liver Disease
THE IMMUNOLOGICAL EFFECTS AND METABOLIC TOLERANCE OF LIPID INFUSION IN PATIENTS WITH CIRRHOSIS.
The study will be an experimental pre-post trial in which patients with ethanol related liver disease (both severe alcoholic hepatitis and decompensated ) admitted in our institute from Jun 2013-Dec 2014 will be enrolled in the…
- Trial name
- NCT02381769
- Testing
- Soybean based lipid emulsion
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholic Hepatitis
Complex Exploratory Study of Alcohol-Associated Hepatitis
Alcohol-associated hepatitis is a clinical syndrome distinct from steatohepatitis or liver cirrhosis. It is associated with high mortality and characterized by an absence of effective treatment, while corticosteroids, which are…
- Trial name
- CESAH (NCT06358196)
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- Pavol Jozef Safarik University
Self-Efficacy, Health Literacy
Health Literacy and Self-efficacy Expectations in Patients With Alcohol-related Liver Cirrhosis
The goal of this observational study is to quantify the health literacy and self-efficacy in people with alcohol-related liver cirrhosis.
- Conditions
- Self-Efficacy, Health Literacy, Liver Cirrhosis, ALD - Alcoholic Liver Disease
- Trial name
- GESA (NCT07169526)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School