Clinical trials: Alcohol-induced Disorders
Teen Drinking
Online Education Hubs and Chat-based Text Messaging for Reducing Alcohol Consumption and Binge Drinking in Adolescents: A Pilot Randomized Controlled Trial
Online education hubs and Chat-based text messaging for reducing alcohol consumption and binge drinking in adolescents: A pilot randomized controlled trial
- Trial name
- NCT07143565
- Testing
- Online platform hub and mHealth Text Messaging, Self-help material
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alcohol Use Disorder
StuDy AimED at Increasing AlCohol AbsTinEnce
The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs.
- Trial name
- NCT05778734
- Testing
- CM-PST, CM only
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Alcohol Use Disorder, PTSD
Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder
The project will examine whether a computerized neuroscience-based cognitive training program can improve cognitive functioning and recovery outcomes among Veterans with Alcohol Use Disorder and co-occurring PTSD.
- Conditions
- Alcohol Use Disorder, PTSD, Cognitive Dysfunction
- Trial name
- NCT02929979
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Abuse
Optimisation of Functional MRI-based Neurofeedback for Alcohol Use Disorders
Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour).
- Trial name
- NCT02406456
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Depression, Anxiety, Alcohol Abuse
Cognitive-Behavioral Therapy for Young Adult Lesbian, Gay and Bisexual: Transdiagnostic Minority Stress Approach
Background: LGB people experience a large number of anxiety and mood disorders, and risk behaviors than heterosexual (Marshall et al., 2011).
- Conditions
- Depression, Anxiety, Alcohol Abuse, Sexual Compulsivity, Unsafe Sex
- Trial name
- NCT03980873
- Testing
- ESTEEM (Effective Sikills to Empower Effective Men)
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Alcoholism
Levetiracetam XR in Very Heavy Drinkers
The primary objectives of this study are to assess the efficacy of levetiracetam XR in increasing the percentage of subjects with no heavy drinking days and in reducing the weekly percentage of heavy drinking days in subjects…
- Trial name
- NCIG 002 (NCT00970814)
- Testing
- BBCET, Levetiracetam XR, Sugar Pill
- Where
- 5 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Bipolar Disorder, Alcohol Dependence
Optimizing Pharmacotherapy for Bipolar Alcoholics
The purpose of this study is to test the efficacy of naltrexone and valproate in the treatment of comorbid bipolar disorder and alcohol dependence.
- Trial name
- NCT00302133
- Testing
- Naltrexone hydrochloride
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alcohol-Related Disorders
Socioeconomic Differences in Alcohol Harm in Finland in a Nationwide Cohort Study
This is a nationwide cohort study of Finnish adults aged 25 and older, who are followed up for the incidence of an alcohol-attributable hospitalization or death.
- Trial name
- NCT05865847
- Testing
- Not applicable, this is an observational study
- Volunteers
- 3,950,000 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Opioid-Related Disorders, Substance-Related Disorders
Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16
The purpose of this study is to examine the subjective, psychomotor, and reinforcing effects of combined alcohol and nitrous oxide intake in healthy volunteers.
- Trial name
- NCT00000264
- Testing
- 30% Nitrous oxide, 0.35 g/Kg ethanol, 0.7 g/Kg ethanol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Alcohol Dependence
Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence
This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
- Trial name
- NCT02557815
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Depression, Anxiety
Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use
This 3-arm study compares the effectiveness of an (1) 8-week mindfulness-based intervention, MBCT-R (Mindfulness-Based Cognitive Therapy for Resilience During COVID-19)+CHA MindWell vs.
- Conditions
- Depression, Anxiety, Substance Use, Stress, Psychological
- Trial name
- NCT04595084
- Testing
- Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alcohol Intoxication
Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention
The goal of this experimental study is to examine the effect of alcohol, gender, and bystander attitudes on bystander barriers and sexual violence intervention among young adult men and women (age 21-20).
- Trial name
- NCT05701865
- Testing
- Alcohol Intoxication- Ascending Limb, Alcohol Intoxication- Descending Limb, No Alcohol Control
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcoholism
OPRM1 A118G SNP, Alcohol Response, and Striatal Dopamine
This study will examine the relationship between variations in a gene called OPRM1 and the response to alcohol. The OPRM1 (Mu-opioid Receptor-1) gene helps regulate brain pathways involved in experiencing pleasure.
- Trial name
- NCT00401999
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Insomnia
Mobile App Intervention for Sleep Problems and Alcohol Use Among Veterans
The goal of this clinical trial is to test the preliminary efficacy of a brief mobile app targeting insomnia symptoms among veterans.
- Trial name
- NCT06487793
- Testing
- Enhanced Insomnia Coach, Sleep hygiene comparator
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alcohol Use Disorder
Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control Subjects
Impulsivity is a central feature of addiction. Nalmefen is an authorized treatment for alcohol addiction. Baclofen has empathically been advocated to have some efficacy in this indication.
- Trial name
- NCT03034408
- Testing
- Nalmefene, Baclofen
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Prof. Daniele Zullino
Substance Use Disorders
Prevention of Substance Use in Youth in Ukraine
The objective of this study is to explore the efficacy of brief motivational interventions (BMIs) for treatment of youth with alcohol and other drug problems after at least 3 months.
- Trial name
- PSUUKR (NCT02347644)
- Testing
- Brief Motivational Interview
- Where
- 2 sites in United States, Ukraine
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cannabis Intoxication, Alcohol Intoxication
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis.
- Trial name
- NCT06293040
- Testing
- Cannabis, Alcohol
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University