Clinical trials: Alcohol-induced Disorders
HIV, Tobacco Use
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
People with HIV (PWH) smoke tobacco cigarettes and drink alcohol at higher rates than the general population, both in the US and internationally, including low- and middle-income countries.
- Conditions
- HIV, Tobacco Use, Alcohol Use Disorder
- Trial name
- NCT06790342
- Testing
- Cystine, Positively Smoke Free, Standard of Care
- Where
- 2 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- University of Chicago
Alcohol Use Disorder, Deep Brain Stimulation
Efficacy and Safety of Dual-target DBS for Treatment-resistant Alcohol Use Disorder
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of dual-target deep brain stimulation for treatment-resistant alcohol use disorder.
- Trial name
- NCT05786872
- Testing
- dual-target deep brain stimulation
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Shanghai Mental Health Center
Alcoholic Hepatitis
Nutritional Interventions in Patients With Alcohol-associated Hepatitis
Alcohol-associated hepatitis (AH) is a life-threatening condition with high 90-days mortality (up to 40%) and limited treatment options.
- Trial name
- NCT06131177
- Testing
- Nutritional supplement
- Volunteers
- 2,000 people
- Sponsor
- Western University, Canada
Alcohol Abuse
Prevention of Alcohol Related Incidents in the US Air Force
Alcohol misuse poses significant public health concerns in the U.S. military. A Brief Alcohol Intervention (BAI) have been shown to reduce alcohol related incidents among Airmen undergoing training.
- Trial name
- AFIV (NCT01398319)
- Testing
- Group Brief Alcohol Intervention, Group Brief Alcohol Intervention Booster, Bystander Intervention
- Where
- United States
- Volunteers
- 26,231 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hiv, Alcohol Problem
Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA
This study is designed to examine the efficacy of an alcohol-focused brief intervention alone versus the brief intervention plus referral to a transdiagnostic cognitive-behavioral intervention to address unhealthy alcohol use and…
- Trial name
- TALC (NCT04955795)
- Testing
- Alcohol Brief Intervention (BI), Common Elements Treatment Approach (CETA) via Telemedicine
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Alabama at Birmingham
Alcohol Use Disorder
Deep Brain Stimulation to Understand and Treat Addiction
This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments.
- Trial name
- Brain-PACER (NCT07341230)
- Testing
- Dual-Target Deep Brain Stimulation, Nucleus Accumbens Deep Brain Stimulation, Ventral Internal Capsule Deep Brain Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Cambridge
Depression, Anger
Clinical Trial With Ziprasidone for the Treatment of Psychiatric Pathology Associated to Alcoholism
Alcohol dependent patients show comorbid psychiatric symptoms, related to malfunction of dopamine, norepinephrine and serotonin neurotransmission, during early recovery.
- Conditions
- Depression, Anger, Anxiety, Alcoholism
- Trial name
- NCT00197951
- Testing
- Treatment of psychiatric symptoms associated to alcoholism
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Alcohol Use Disorder, Alcohol Abuse
Effectiveness of a WeChat-based Alcohol Consumption Intervention Mini-program ("Sober Time ACT") in China
The purpose of this study is to explore whether "Sober Time ACT", a digital intervention tool for alcohol use developed based on wechat mini program, is effective in improving risky alcohol use among Chinese local drinkers.
- Trial name
- NCT05827822
- Testing
- Sober Time ACT
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Mental Health Center
HIV-infection/Aids, Intimate Partner Violence
Improving HIV Care Engagement Among Ugandan Adolescent Girls and Young Women: The Kisoboka Mukwano Intervention
This study will develop and pilot test a couples-based intervention to help adolescent girls and young women living with HIV (WLHIV (15-24 years) living in Uganda access HIV care and improve the outcomes of their HIV treatment by…
- Conditions
- HIV-infection/Aids, Intimate Partner Violence, Domestic Violence, Alcohol Use Disorder
- Trial name
- NCT05947539
- Testing
- Kisoboka Mukwano ("It is possible, my love!") Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 80 people
- Sponsor
- Arizona State University
Alcoholism, Alcohol Dependence
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
This study will assess the ability of naltrexone (Revia) to reduce the risk of relapse in Alaska natives with alcohol dependence.
- Trial name
- NCT00000451
- Testing
- sertraline, naltrexone
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Yale University
Alcohol Consumption, Alcohol Use Disorder
Effectiveness of an Intervention in Patients With Excessive Alcohol Consumption
Main objective: to verify the effectiveness of a brief intervention, based on the motivational interview (MI), in patients with excessive alcohol consumption assisted in Primary Care (PC).
- Trial name
- ALCO-AP20 (NCT04811729)
- Testing
- Motivational interview, Medical advice
- Where
- Spain
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Alcoholic Hepatitis
Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline
Alcoholic hepatitis represents one of the more serious forms of alcoholic liver disease. Critically ill patients with alcoholic hepatitis have high morbidity and mortality rate.
- Trial name
- NCT01455337
- Testing
- pentoxifylline, Prednisolone
- Volunteers
- 126 people
- Sponsor
- Inje University
Binge Drinking, Suicidal Ideation
Open Pilot Trial Evaluating an Avatar-Guided Intervention for Emerging Adults With Alcohol Use Problems and Suicide Risk
This study is an open pilot usability trial to test the 1) usability of a newly developed mobile health intervention to help manage suicidal ideation and alcohol use problems and 2) feasibility of research protocols with emerging…
- Trial name
- EA-Avatar (NCT06595862)
- Testing
- EA-Avatar
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Liver Cirrhosis, Alcoholic
Feasibility of Wearable Biosensors for Monitoring Daily Activity, Heart Rate, and Sleep Among Patients With Decompensated Cirrhosis
In this protocol, the investigators will determine compliance, acceptability, and patient satisfaction regarding the use of remote monitors and summarize changes in activity over time among patients with decompensated cirrhosis.
- Trial name
- NCT06057870
- Testing
- Application on Apple watch
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Alcoholic Cirrhosis
Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients
The aim of this study was assesment of splanchnic and systemic hemodynamic effects of chronic administration (2 month) of spironolactone or propranolol, alone or in association in alcoholic cirrhotic patients.
- Trial name
- NCT00188045
- Testing
- Propranolol - Spironolactone
- Volunteers
- 54 people
- Sponsor
- University Hospital, Angers
Alcohol Addiction
Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System
About 10% of the calculable loss of health and quality of life in industrial countries can be attributed to excessive alcohol consumption.
- Trial name
- NCT03854942
- Testing
- Naltrexone
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Alcohol Use Disorder (AUD)
Medication Development in Alcoholism: Suvorexant Versus Placebo
The primary hypotheses under test are that alcohol dependent subjects treated with suvorexant will report decreased craving for alcohol following alcohol exposure in the laboratory and report significantly less drinking under…
- Trial name
- NCT04229095
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- The Scripps Research Institute
Alcohol Consumption
Culturally Adapted Brief Intervention for Heavy Drinking Hispanic Men
In this comparative-effectiveness study, investigators will recruit 400 English-speaking, Spanish-speaking, or bilingual heavy-drinking Mexican-origin men admitted to a community hospital for medical treatment of an…
- Trial name
- Project Valor (NCT02429401)
- Testing
- Non-adapted brief motivational interview, Culturally adapted brief motivational interview
- Where
- 2 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Alcoholism, Attention Deficit Disorder
Treatment of Patients With Alcoholism and Attention Deficit Disorder
This study of persons with both alcoholism and ADHD will determine whether adding the drug methylphenidate to a standard treatment program will decrease alcohol use.
- Trial name
- NCT00261872
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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