Clinical trials: Alcohol-induced Disorders
PTSD, Alcohol Dependence
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence
Purpose: Phase I focus groups with clinicians and patients will gather qualitative data to focus and inform the content of Phase II.
- Trial name
- NCT00622921
- Testing
- Couples-based behavioral psychotherapy
- Where
- United States
- Sponsor
- Yale University
Liver Diseases, Alcoholic, Fibrosis
Screening At-risk Populations for Hepatic Fibrosis With Non-invasive Markers
Prospective screening study at Odense University Hospital to assess the effect of transient elastography and other serum and imaging markers of liver fibrosis to detect advanced fibrosis (Kleiner Fibrosis score F3-F4) in patients…
- Trial name
- SIPHON (NCT03308916)
- Testing
- transient elastography, Enhanced liver fibrosis test, Indirect serum markers of liver fibrosis
- Where
- Denmark
- Volunteers
- 6,500 people
- Sponsor
- Maja Thiele
Alcohol Use Disorder
Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control Subjects
Impulsivity is a central feature of addiction. Nalmefen is an authorized treatment for alcohol addiction. Baclofen has empathically been advocated to have some efficacy in this indication.
- Trial name
- NCT03034408
- Testing
- Nalmefene, Baclofen
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Prof. Daniele Zullino
Substance Use
Primary Connections for Youth and Families
The goal of this clinical trial is to compare a standard adolescent-only approach to substance use screening, brief intervention, and referral to treatment to a in primary care settings.
- Trial name
- PCYF (NCT05964010)
- Testing
- Standard Screening, Standard Psychoeducation, Standard Brief Negotiated Interview (BNI)
- Where
- United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Alcohol Use Disorder (AUD), Obesity (BMI Equal to or >30)
Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes
This study will examine two doses of 1.0 mg and 2.0 mg of Semaglutide versus placebo in patients with Alcohol Use Disorder (AUD) and Obesity (Ob) to assess if these doses improve alcohol craving, stress and alcohol use outcomes.
- Trial name
- SEMA AUD (NCT07772960)
- Testing
- Semaglutide 1.0 mg, Semaglutide 2.0 mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD)
A Critical Illness Recovery Navigator for Alcohol
Excessive alcohol consumption is common in patients admitted to the intensive care unit (ICU). Among patients who survive an ICU admission, excessive alcohol consumption is associated with a higher risk of being admitted the…
- Trial name
- CIRNA (NCT03059082)
- Testing
- Recovery Navigator on an as needed basis up to 6 months, Recovery Navigator prior to hospital discharge, No interaction with Recovery Navigator
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Alcohol Abuse
Contingency Management Treatment Duration
310 alcohol abusing or dependent patients beginning intensive outpatient day treatment at community-based clinics will be randomly assigned to one of four conditions: (a) standard treatment as usual (ST) at the clinic without…
- Trial name
- Duration (NCT00732342)
- Testing
- Contingency Management
- Where
- 5 sites in United States
- Volunteers
- 310 people
- Sponsor
- UConn Health
Alcoholism
ALK21-010: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol-dependent Adults
This was a Phase 3, multi-center extension of Alkermes' Study ALK21-003EXT (NCT01218971) to further assess the long-term safety of repeat monthly doses of Medisorb® naltrexone (VIVITROL®).
- Trial name
- NCT00156923
- Testing
- Medisorb naltrexone 380 mg, Medisorb naltrexone 190 mg
- Volunteers
- 108 people
- Sponsor
- Alkermes, Inc.
Cannabis, Alcohol Effect
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II
The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
- Conditions
- Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
- Trial name
- THC-ETOH-II (NCT02710097)
- Testing
- Active inhaled cannabis, Active Oral Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Nonorganic Insomnia, Neurodevelopmental Disorders
Better Nights, Better Days for Children With Neurodevelopment Disorders
More than 90% of children with neurodevelopmental disorders (NDD) experience sleep problems, whereas less than 25% of typically developing children experience sleep problems.
- Conditions
- Nonorganic Insomnia, Neurodevelopmental Disorders, Primary Insomnia
- Trial name
- BNBD-NDD (NCT02694003)
- Testing
- BNBD-NDD Intervention
- Where
- Canada
- Volunteers
- 218 people
- Sponsor
- IWK Health Centre
Alcohol Dependence
A New Pharmacotherapy for Alcohol Dependence: Olanzapine
Craving for alcohol has been related to loss of control drinking and is a major target of biological and behavioral interventions for alcohol dependence.
- Trial name
- NCT00746785
- Testing
- 2.5 mg Olanzapine, 5mg Olanzapine
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- The Mind Research Network
Alcoholism
Study To Examine Effect Of CP-866,087 On Consumption And Craving Of Alcohol In Alcohol Dependent Subjects.
Test the hypothesis that increasing doses of CP-866,087 will decrease the total number of drinks consumed during a 2 hour acute alcohol consumption assessment and to determine the safety and tolerability of multiple doses of…
- Trial name
- NCT00147576
- Testing
- CP-866,087
- Where
- 11 sites in United States
- Volunteers
- 88 people
- Sponsor
- Pfizer
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure
Although the adverse effects associated with prenatal alcohol exposure (PAE) are well known, many women continue to drink heavily during pregnancy, putting their infants at risk for fetal alcohol spectrum disorders.
- Trial name
- NCT04395196
- Testing
- Choline bitartrate
- Where
- South Africa
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Suicidal Ideation, Social Behavior
Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA Survey Protocol
The objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in Mexico City (approximately 30,000 students aged between 15 and 22 years), taking also into…
- Conditions
- Suicidal Ideation, Social Behavior, Depression, Depressive Disorder
- Trial name
- TEDUCA (NCT04067076)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 30,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Alcohol-Related Disorders, Substance-Related Disorders
Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance…
- Conditions
- Alcohol-Related Disorders, Substance-Related Disorders, Mental Health, Reproductive Health
- Trial name
- NCT05910580
- Testing
- Screening, Brief Intervention, and Referral to Treatment (SBIRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Emory University
Alcohol Dependence
ALK33-005: A Study of ALKS33 (RDC-0313) in Adults With Alcohol Dependence
This study will evaluate the safety and efficacy of ALKS33 (RDC-0313) compared with placebo in adults with alcohol dependence. There will be 11 study visits conducted over a period of about 4 months.
- Trial name
- NCT00981617
- Testing
- ALKS33 (RDC-0313) (1 mg), ALKS33 (RDC-0313) (2.5 mg), ALKS33 (RDC-0313) (10 mg)
- Where
- 27 sites in United States
- Volunteers
- 406 people
- Sponsor
- Alkermes, Inc.
Alcohol-related Disorders, Alcohol Drinking
Medication and Counseling for Controlled Drinking (Project SMART)
The purpose of this study is to study the effectiveness of medication and specialized psychotherapy in helping gay and bisexual men who do not want to quit drinking learn how to reduce their drinking to healthier levels.
- Conditions
- Alcohol-related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
- Trial name
- NCT00444418
- Testing
- Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Inflammatory Response
An Inflammatory Challenge Using Endotoxin
The study design consists of a randomized, double-blind, placebo-controlled trial of low dose endotoxin. The low dose endotoxin challenge induces a transient systemic inflammatory response with normalization of cytokine levels…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
- Trial name
- NCT04310423
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Dependence, Alcohol Abuse
Community Reinforcement and Family Training (CRAFT) for Treatment-resistant Individuals With Alcohol Use Disorders
The present study examines the efficacy of the Community Reinforcement and Family Training (CRAFT) for Concerned Significant Others (CSOs) of individuals with alcohol use disorders (AUDs) using a randomized waiting list (WL)…
- Trial name
- CRAFT (NCT02112396)
- Testing
- Community Reinforcement and Family Training
- Where
- Germany
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
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