Clinical trials: Alcohol-induced Disorders
Alcohol Dependence
Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study
12-week, open-label study of topiramate in hospitalized patients with alcoholism
- Trial name
- THoPA-O (NCT01135602)
- Testing
- Topiramate
- Where
- 2 sites in Thailand
- Volunteers
- 150 people
- Sponsor
- Chiang Mai University
Nonsuicidal Self Injury, Alcohol Abuse
Technology Enhanced Adolescent Mental Health (TEAM)
Adolescent nonsuicidal self-injury (NSSI) and alcohol misuse, alone and especially in combination, portend significant functional impairment in adulthood (e.g., relationship dysfunction, depression, suicidality).
- Conditions
- Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
- Trial name
- TEAM (NCT05343039)
- Testing
- Non-invasive Transcutaneous Nerve Stimulation (tVNS), No Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Alcohol Use Disorder, Alcoholic Hepatitis
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH
Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant…
- Trial name
- NCT03845205
- Testing
- Integrated AUD Treatment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
HIV/AIDS and Infections, Drug Abuse
A Community-University Approach to Preventing HIV
Examine the feasibility and acceptability of delivering the S4E intervention to 20 African-American youths between the ages 16-21 in Flint, Michigan.
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03938077
- Testing
- Storytelling 4 Empowerment
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Alcohol Dependence
A Tailored Physical Activity Smartphone App for Patients With Alcohol Dependence
The purpose of the study twofold: first, a smartphone-based physical activity application (app), which will be called Fit\&Sober, will be developed and tailored specifically for patients with alcohol use disorders (AUDs); then…
- Trial name
- NCT02958280
- Testing
- Fit&Sober App, Brief Advice
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Butler Hospital
Alcoholic Intoxication
Interest of tDCS in Help for Supporting Alcohol Abstinence
The aim of the study is to evaluate in patients with alcohol disorder and forehand weaned the efficiency of 10 active tDCS sessions versus 10 sham (placebo) sessions in the support of abstinence at 3 months.
- Trial name
- ITAMAA (NCT03287154)
- Testing
- Active tDCS stimulations
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Henri Laborit
Alcoholism, Alcohol Abuse
EMPOWER AUD Pivotal Trial
Multi-site, double-blinded, prospective, randomized, sham-controlled study
- Conditions
- Alcoholism, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT05948605
- Testing
- Empower Neuromodulation System
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Theranova, L.L.C.
Alcoholic Liver Disease, Non-Alcoholic Fatty Liver Disease
Integrated Approaches for Identifying Molecular Targets in Liver Disease
To provide a framework for successful clinical trials testing novel targets for therapy in liver disease. To identify molecular and cellular drivers of liver disease to provide a molecular classification and study the…
- Conditions
- Alcoholic Liver Disease, Non-Alcoholic Fatty Liver Disease, Steatohepatitis, Nonalcoholic, Steatohepatitis
- Trial name
- InLi (NCT03915002)
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder
Effects of Nimodipine on Alcohol Drinking
This is a randomized placebo-controlled trial (RCT). Participants will be non-treatment seeking adults, 21-50 years of age, with Alcohol Use Disorders.
- Trial name
- NCT07681869
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Alcohol Withdrawal Syndrome
Treatment of Alcohol Withdrawal Syndrome With Alpha-2 Agonists and/or Anticonvulsants
Complicated alcohol withdrawal syndrome (AWS) increases morbidity and mortality of hospitalized, medically ill patients. The Psychosomatic Medicine Service is commonly consulted to assist in the management of these patients when…
- Trial name
- NCT05438641
- Testing
- BZDP-Sparing Protocol, BZDP-Based Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Alcohol Dependence, Alcohol-Related Disorders
Remote Alcohol Monitoring and Episodic Thinking
Nearly 18% of United States adults meet criteria for alcohol dependence sometime in their lifetime, with only 24% of those individuals ever receiving any treatment for their disorder (Hasin et al., 2007).
- Trial name
- RMET (NCT03340051)
- Testing
- Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Adolescent Substance Use
Guiding Good Choices for Health
This study evaluates the feasibility and effectiveness of implementing Guiding Good Choices (GGC), an anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems.
- Trial name
- GGC4H (NCT04040153)
- Testing
- Guiding Good Choices
- Where
- 3 sites in United States
- Volunteers
- 3,636 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Abuse, Substance Abuse
Project BrEAtHe: A Culturally Tailored MBSR Intervention for Young Adult Black Men
The purpose of this study is to create a program focused on mindfulness and stress reduction specifically tailored to young adult Black males.
- Conditions
- Alcohol Abuse, Substance Abuse, Post Traumatic Stress Disorder
- Trial name
- BrEAtHe (NCT07009977)
- Testing
- self-guided mHealth app only, self-guided mHealth app + 'real-time' feedback
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol Dependence
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission.
- Trial name
- NGFN PLUS TP13 (NCT01503931)
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hepatitis, Alcoholic
Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis
To determine the efficacy and safety S-adenosyl-l-methionine in alcoholic hepatitis with cholestasis.
- Trial name
- NCT02024295
- Testing
- Ademethionine, Polyene Phosphatidyl choline
- Where
- 2 sites in China
- Volunteers
- 118 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Depression, Anxiety
The EARN-Health Trial of Financial Savings and Health
The current literature in social epidemiology and public health suggests that low financial savings has an unsurprising negative relationship with subjective well-being, and increases the odds of making visits to a healthcare…
- Conditions
- Depression, Anxiety, Alcohol Abuse, Tobacco Abuse
- Trial name
- EARN-Health (NCT02185612)
- Testing
- Savings program
- Where
- United States
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alcohol Abuse or Dependence
Guided Self-Change Prevention Program for Alcohol Abuse in Adolescents in Educational Settings
This study corresponds to a pretest-posttest randomized experimental design with two arms. Arm 1 includes Guided Self-Change program, and Arm 2 a psychoeducational program to promote healthy habits.
- Trial name
- PREVENALC (NCT05281172)
- Testing
- Guided Self-Change therapy (GSC), Psychoeducation program about healthy habits
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Alcohol Use Disorder, Anxiety Disorder/Anxiety State
Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
Alcohol dependence is among the most common and costly public health problems affecting the nation. Among individuals with alcohol use disorder (AUD), those with (vs.
- Conditions
- Alcohol Use Disorder, Anxiety Disorder/Anxiety State, Stress Disorder, Hypothalamic Pituitary Adrenal
- Trial name
- NCT03056872
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adolescent Drinking, Adolescent Problem Behavior
Mindfulness Mobile App to Reduce Adolescent Substance Use
Substance-abusing youth - especially those who are involved in the juvenile justice system - are at higher risk than nonusers for mental health problems, including depression, conduct problems, personality disorders, suicidal…
- Trial name
- Qlarity (NCT04027075)
- Testing
- Qlarity app users
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Depression - Major Depressive Disorder, Schizophenia Disorder
A Novel Blood Test as a Biomarker in Mental Health
This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital…
- Conditions
- Depression - Major Depressive Disorder, Schizophenia Disorder, Psychosis, Mania (Neurotic)
- Trial name
- LEADING-MH (NCT06856161)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Fraser Health
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