Clinical trials: Alcohol-induced Disorders
Alcoholic Hepatitis
Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with alcoholic hepatitis. The liver might play an important role in this stress-catabolism by increasing the production of urea during the…
- Trial name
- NCT01245257
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Alcohol Dependence
The Efficacy of A Smartphone-based Support System to Reinforce Alcohol Abstinence in Treatment-seeking Patients
Background: Interactive and mobile technology to manage alcohol use problem potentially provide continuing care by offering emotional and instrumental support anywhere and in time, but the effectiveness for maintaining abstinence…
- Trial name
- NCT02385643
- Testing
- SmartPhone Support System
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Ming-Chyi Huang
Alcohol, Alcohol Use Disorders
A Phase I Study of the Interaction of Alcohol With Oral AFA-281 in Healthy Volunteers
The goal of this clinical trial is to evaluate if alcohol interacts with the drug candidate AFA-281 in adults (healthy volunteers). This trial will evaluate blood concentration levels of AFA-281 and ethanol.
- Trial name
- NCT06719908
- Testing
- AFA-281 is a small molecule, orally available, Alcohol (Ethanol)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Alcohol Use Disorder, Depression
Project VALOR: Veteran Stress and Wellbeing
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior veterans as the move into their second year post-Army.
- Trial name
- NCT06095817
- Testing
- Internet Delivered Brief Intervention (IDBI)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cornell University
Alcoholism
Health Focused Motivational Treatment for Alcohol Dependent Veterans
The purpose of this study is to determine whether a health focused motivational intervention will reduce alcohol use for dependent veterans who are receiving outpatient alcohol and drug treatment.
- Trial name
- NCT00252590
- Testing
- Health Motivational Feedback, Health Education, Control - treatment as usual
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Hepatitis, Chronic Hepatitis C
The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients
The investigators will evaluate the efficacy of high dose vitamin C in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.
- Conditions
- Chronic Hepatitis, Chronic Hepatitis C, Chronic Alcoholic Hepatitis
- Trial name
- NCT01413360
- Testing
- High dose vitamin C
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Alcohol Abuse, Post-Traumatic Stress Disorder
Pilot Evaluation of the VetChange Mobile App for Veterans With PTSD Who Engage in Problem Drinking
Concept: Alcohol misuse is common among Veterans with PTSD. It has been proposed that this high comorbidity is the result of "self-medication," with alcohol being used to alleviate common PTSD symptoms (e.g., hyperarousal, sleep…
- Trial name
- NCT03208738
- Testing
- VetChange, web-based drinking assessment and feedback tool (AFT)
- Volunteers
- 280 people
- Sponsor
- Eric Kuhn
Post-traumatic Stress Disorder, Alcohol Abuse
Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Recent needs assessments suggest that difficulties exist in care coordination between emergency medical services (EMS) systems and primary care for injured adolescents with alcohol problems and post-traumatic stress disorder…
- Conditions
- Post-traumatic Stress Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- ATRSCC (NCT00619255)
- Testing
- Adolescent Trauma Support Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Alcoholism, Alcohol Withdrawal
Outpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to compare a fixed-schedule therapy versus a symptom-triggered therapy for alcohol withdrawal syndrome in medical outpatients.
- Trial name
- NCT00136617
- Testing
- chlordiazepoxide
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Hvidovre University Hospital
Fetal Alcohol Spectrum Disorders
Nutritional Risk Factors for FASD in Ukraine
Interventional study randomizing pregnant women at two sites in Ukraine who have or have not already consumed moderate to heavy levels of alcohol in pregnancy to receiving a standard prenatal vitamin supplement with or without…
- Trial name
- NCT03782935
- Testing
- Prenatal multivitamin mineral supplement
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alcohol Use Disorder
Long-term Recovery: Longitudinal Study of Neuro-behavioral Markers of Recovery and Precipitants of Relapse
The goals of this study are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions.
- Trial name
- NCT04788004
- Testing
- Online survey
- Where
- United States
- Volunteers
- 733 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcoholism
Combined Pharmacotherapies for Alcoholism
This study would like to test whether the combination of ondansetron and naltrexone will be superior to either medication alone or placebo in the treatment of alcohol dependence.
- Trial name
- NCT00768508
- Testing
- Ondansetron 4 ug/kg b.i.d. + Cognitive Behavioral Therapy, Naltrexone 50 mg/day + Cognitive Behavioral Therapy, Ondansetron 4 ug/kg b.i.d.+ Naltrexone 50 mg/day + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bankole Johnson
Alcohol Use Disorder (AUD)
Acceptability and Feasibility Study of Non-alcoholic Beverages
This project will elucidate the acceptability and feasibility of incorporating provision of non-alcoholic beers into alcohol use disorder treatment, for patients interested in using non-alcoholic beers as part of their recovery…
- Trial name
- NCT07451574
- Testing
- Non-alcoholic beer, Sparkling water
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Heavy Drinking, Alcohol Abuse
Effects of Long-term Exercise on Various Parameters in Heavy Drinkers
The purpose of this research is to examine the effects of long-term aerobic exercise of moderate intensity on psychological, physiological, biochemical, physiological and alcohol-related parameters in heavy drinkers, in order to…
- Conditions
- Heavy Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT02664766
- Testing
- Exercise training program
- Volunteers
- 13 people
- Sponsor
- University of Thessaly
Alcohol Use Disorder, Mild, Alcohol Use, Unspecified
My Choices: Efficacy and Implementation Study
The aim of the study is to assess the efficacy of the My Choices - Alcohol program by comparing alcohol-use of people before and after doing the program to people that did not do the program on the same period of time (3 months).
- Trial name
- NCT05358613
- Testing
- My Choices
- Where
- 5 sites in Canada
- Volunteers
- 167 people
- Sponsor
- Université du Québec à Trois-Rivières
Alcoholic Liver Disease
Long Term Effect of Aggressive Nutritional Management on Survival in Patients With Alcoholic Liver Disease
Patient found to be malnourished after the nutritional evaluation would be randomized in the two groups of the study. The control group would receive standard nutritional counseling from a trained dietician where as those in the…
- Trial name
- NCT02140294
- Testing
- Polymeric nutritional supplements, Standard Nutrional Treatment
- Where
- India
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Use Disorder
NIAAA Natural History Protocol
Background: About 17 million adults had an alcohol use disorder in 2012. Researchers want to follow people that have alcohol problems and want treatment, as well as those who do not want treatment and healthy volunteers.
- Trial name
- NCT02231840
- Where
- United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
A Novel Human Lab Model for Screening AUD Medications
This study design consists of a randomized, double-blind, placebo-controlled, 3-arm, parallel-group study of naltrexone (50 mg QD) and varenicline (1 mg BID).
- Trial name
- NCT04249882
- Testing
- Naltrexone, Varenicline
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, Los Angeles
PTSD, AUD
PTSD and Alcohol Couples Treatment for Veterans
Treatment of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) treatment for Veterans is challenging for Veterans.
- Trial name
- PACT-V (NCT07388654)
- Testing
- COPE + BFIT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Alcohol-Related Disorders, Cocaine-Related Disorders
Interactions Between Cocaine and Ethanol and Disulfiram - 1
The purpose of this study is to assess potential interactions between intravenous cocaine and ethanol and oral disulfiram.
- Trial name
- NCT00094289
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
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