Clinical trials: Alcohol-induced Disorders
Alcoholism
Naltrexone for Relapse Prevention
This study is to evaluate the safety and effectiveness of an injectable slow releasing preparation of naltrexone to reduce alcohol consumption and risk of relapse in alcohol-dependent subjects.
- Trial name
- NCT00000442
- Testing
- naltrexone (Revia)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- UConn Health
Domestic Violence, Substance Abuse
Treatment of Intimate Partner Violence and Substance Abuse in a Substance Abuse Treatment Facility
Intimate partner violence is a significant societal problem. There is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists.
- Trial name
- NCT00847873
- Testing
- substance abuse/domestic violence treatment, Cognitive behavioral therapy addressing substance abuse
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Alcohol Withdrawal
Study of Exploratory Plasmatic Markers of Alcohol Withdrawal
This research focuses on alcohol withdrawal in hospitals and its potential neurological consequences. Alcohol withdrawal is an event that induces physical symptoms, such as tremors, sweating, anxiety and requires medical support.
- Trial name
- STEP-AW (NCT05216705)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alcohol Use Disorder
A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder
The objective of this proof-of-concept study to evaluate mazdutide in participants with alcohol use disorder (AUD). For any individual participant, the maximum duration of study participation is approximately 36 weeks, including…
- Trial name
- NCT06817356
- Testing
- Mazdutide
- Where
- 25 sites in United States
- Volunteers
- 308 people
- Sponsor
- Eli Lilly and Company
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Alcohol; Liver
Integrating Care for Patients With Alcohol Liver Disease and Alcohol Use Disorders
Alcohol related liver disease (ALD) contributes to 50% cases of cirrhosis worldwide and is the leading indication for liver transplant in North America.
- Trial name
- NCT05375682
- Testing
- Integrated care program
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Alcohol Use Disorder
Randomized Diagnostic Trial Comparing Ethylglucuronide and Ethanol
Background: Alcohol use disorders represent a major health burden. Efforts aiming at reducing alcohol-related harm include early detection of those with risky drinking habits as well detection of early relapse in patients with…
- Trial name
- NCT03276520
- Testing
- ethyl glucuronide, ethanol
- Volunteers
- 162 people
- Sponsor
- Hospital Clinic of Barcelona
Alcohol Use Disorder
Pioglitazone for the Treatment of Alcohol Use Disorder
Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best.
- Trial name
- PAUSE (NCT03864146)
- Testing
- Brief Behavioral Compliance Enhancement Treatment
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Alcohol Use Disorder
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD.
- Trial name
- NCT03667846
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Alcohol Use Disorder, Alcohol Abuse
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a significant public health problem, with prevalence rates of 13.9% for current and 29.1% for lifetime diagnosis (Grant et al., 2015).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol Dependence
- Trial name
- ABQTREAT (NCT03842670)
- Testing
- Cognitive Behavior Therapy, Mindfulness Based Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of New Mexico
Severe Alcoholic Hepatitis
A Comparison of Fecal Microbiota Transplantation and Steroid Therapy in Patients With Severe Alcoholic Hepatitis.
Study population: Patients attending the Out Patient Department and admitted to Institute of Liver and Biliary Sciences. Study design: Prospective randomized controlled trial Study period: One year- January 2017- December 2018…
- Trial name
- NCT03091010
- Testing
- Fecal Microbiota Transplantation, Steroids
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholism, Substance-Related Disorders
Intranasal Oxytocin Effects in Alcohol Withdrawal and Dependence; Follow-up Study
This study is an assessment of the long-term effect of oxytocin nasal spray on alcohol withdrawal and dependence in adults admitted for detoxification of alcohol after 60 days and 1 year.
- Trial name
- NCT03339024
- Testing
- intranasal oxytocin spray, intranasal spray without oxytocin
- Where
- Norway
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Alcohol Dependence
Extended-Release vs. Oral Naltrexone Alcohol Treatment in Primary Care
The proposed study is a pragmatic, randomized, open-label clinical trial of 24 weeks of XR-NTX vs. O-NTX using a COMBINE-adapted Medical Management primary care treatment model.
- Trial name
- X-ON (NCT01893827)
- Testing
- XR-NTX (Extended-Release Naltrexone), Oral Naltrexone (O-NTX)
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- NYU Langone Health
Alcohol Abuse, Cannabis Abuse
Trial of Computerized SBI to Reduce Teen Alcohol Use
The goal of this project is to test the effectiveness of a computer-facilitated alcohol screening and brief intervention (c-ASBI) system for 12- to 18-year-old primary care patients in a multi-site, randomized comparative…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Nicotine Dependence
- Trial name
- NCT01784627
- Testing
- c-ASBI
- Where
- 6 sites in United States
- Sponsor
- Boston Children's Hospital
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)
To assess the safety, feasibility and preliminary efficacy of ketamine-enhanced therapy (KET) for alcohol use disorder (AUD) and comorbid major depressive disorder (MDD) in an open-label, single arm, pilot clinical trial.
- Conditions
- Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD), Comorbidities and Coexisting Conditions
- Trial name
- KET-DUAL (NCT07247370)
- Testing
- Ketamine, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Drink Too Much, Drinking, Binge
Group-based Intervention for Club Patrons
The purpose of this study is to develop and test a group-based strategy for encouraging groups of young adults who are engaged in party behaviors at nightclubs to intervene with each other to reduce harms associated with overuse…
- Conditions
- Drink Too Much, Drinking, Binge, Drunk, Drug Use
- Trial name
- NCT03652688
- Testing
- Nightlife Safety Plans (NSP), Fire Safety
- Where
- 2 sites in United States
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Alcohol Use Disorder, Alcohol Abuse/Dependence
Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for the treatment of type 2 diabetes and obesity, have shown promise as a novel treatment for alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse/Dependence, Alcohol Dependence, Alcoholism
- Trial name
- DUALPSYCHIATRY (NCT06939088)
- Testing
- Tirzepatide
- Where
- 2 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder
Medication Development in Alcoholism: Apremilast Versus Placebo
The primary hypotheses under test are that alcohol dependent subjects treated with apremilast will report decreased craving for alcohol following alcohol exposure in the laboratory and report significantly less drinking under…
- Trial name
- NCT03175549
- Testing
- Apremilast
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Scripps Research Institute
Alcoholism, Depression
Pharmacological Intervention Project (Fluoxetine)
This is a large scale study involving fluoxetine (Prozac) versus a placebo in the treatment of adolescents with alcohol use disorder (AUD) and major depression (MDD).
- Trial name
- FIDAA (NCT00027378)
- Testing
- fluoxetine (Prozac)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Alcohol Addiction
Guided and Unguided Internet Treatment for Problematic Alcohol Use
The purpose of this study was to determine whether a 10-week internet-based program based on cognitive behavioral therapy (CBT) is effective in the treatment of alcohol problems, and if having therapist guidance leads to greater…
- Trial name
- NCT02384304
- Testing
- Choice, Messages, Self help
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
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