Clinical trials: Alcohol-induced Disorders
Alcohol Use Disorder
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder.
- Trial name
- NCT04098302
- Testing
- Dutasteride Capsules
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- UConn Health
Tobacco Abstinence
Varenicline For Smokers In Recovery From Alcohol Dependence
The goal of this proposal is to explore the potential effectiveness of varenicline to treat tobacco dependence among recovering alcoholic smokers who, as a group, are at high risk for tobacco-caused morbidity and mortality.
- Trial name
- NCT01092702
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Dependence
Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism
The overarching aim of this trial is to evaluate naltrexone's efficacy in light of genetic variation and brain response to alcohol cues utilizing a neuroimaging paradigm. This trial has four specific aims.
- Trial name
- NCT00920829
- Testing
- Naltrexone 50 Mg
- Where
- 2 sites in United States
- Volunteers
- 358 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, HIV-infection/Aids
Development of an Intervention to Reduce Heavy Drinking and Improve HIV Care Engagement Among Fisherfolk in Uganda
Fisherfolk are a high risk population for HIV and are prioritized to receive antiretroviral treatment (ART) in Uganda, but risky alcohol use among fisherfolk is a barrier to HIV care engagement; multilevel factors influence…
- Trial name
- NCT03919695
- Testing
- Kisoboka: Behavioral and Structural Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- San Diego State University
Alcohol Consumption, Alcohol Intoxication
A Text Message Behavioral Intervention to Reduce Alcohol Consumption in Young Adults
Investigators aim to test the effectiveness of a text-message-based behaivoral intervention in reducing binge drinking among young adults.
- Trial name
- TRAC (NCT01688245)
- Testing
- SMS Assessments & Feedback, SMS Assessments
- Where
- United States
- Volunteers
- 765 people
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Harmful Alcohol Use
Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment
Many people who have risky alcohol use or alcohol dependence do not seek help, often is due to concerns about potential consequences or feelings of shame.
- Conditions
- Alcohol Abuse, Harmful Alcohol Use, Hazardous Alcohol Use, Hazardous Drinking
- Trial name
- NCT06675812
- Testing
- Information intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorder, Alcohol Abuse
Effectiveness of a WeChat-based Alcohol Consumption Intervention Mini-program ("Sober Time ACT") in China
The purpose of this study is to explore whether "Sober Time ACT", a digital intervention tool for alcohol use developed based on wechat mini program, is effective in improving risky alcohol use among Chinese local drinkers.
- Trial name
- NCT05827822
- Testing
- Sober Time ACT
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Dependence
Effects of Sulfasalazine on BOLD Response to Alcohol Cues
The overarching objective of this pilot study is to apply both neuroimaging and pharmacogenetic tools to the study of alcohol dependence.
- Trial name
- NCT01312129
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Mind Research Network
Alcoholism, Depression
Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism.
The aim of the present study was to examine the influence of memantine, a noncompetitive NMDA receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor, escitalopram.
- Trial name
- NCT00368862
- Testing
- Ebixa (memantine hydrochloride), Cipralex (escitalopram)
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Fetal Alcohol Spectrum Disorders
Nutritional Risk Factors for FASD in Ukraine
Interventional study randomizing pregnant women at two sites in Ukraine who have or have not already consumed moderate to heavy levels of alcohol in pregnancy to receiving a standard prenatal vitamin supplement with or without…
- Trial name
- NCT03782935
- Testing
- Prenatal multivitamin mineral supplement
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alcoholic Hepatitis
Granulocyte Colony Stimulating Factor Four Week Plus N-Acetyl Cysteine in Severe Alcoholic Hepatitis
Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients died within first 6 months after the detection of the clinical syndrome.
- Trial name
- NCT05840640
- Testing
- Standard Medical Therapy, G-CSF, G-CSF and NAC
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Alcohol Use Disorder
Evaluating Cannabidiol as a Novel Anticraving Medication for Alcohol Use Disorder
This human laboratory study aims to assess the effects of cannabidiol on alcohol consumption and craving in participants with alcohol use disorder.
- Trial name
- NCT06512389
- Testing
- Oral solution
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Anxiety Sensitivity, Hopelessness
The UniVenture Program
UniVenture is a research partnership with one common goal: to adapt, test, and begin sharing an effective, sustainable, targeted wellness program to tackle the timely social issue of heavy drinking and other substance misuse on…
- Conditions
- Anxiety Sensitivity, Hopelessness, Sensation Seeking, Impulsivity
- Trial name
- NCT05383989
- Testing
- UniVenture Hopelessness manual, UniVenture Anxiety Sensitivity manual, UniVenture Sensation Seeking manual
- Where
- 5 sites in Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sherry Stewart
Alcohol Abuse
Family Based Contingency Management for Adolescent Alcohol Abuse
The goal is to adapt the family-based CM treatment to target primary adolescent alcohol abuse and dependence. Specific Aim 1 is to provide a preliminary demonstration of the efficacy of a family-based CM intervention to treat…
- Trial name
- NCT00595478
- Testing
- Motivational Enhancement Therapy (MET)/CBT+CM, Motivational Enhancement Therapy (MET)/CBT
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcoholism
The Teachable Moment: Screening and Brief Intervention for Admitted Trauma Patients
The American College of Surgeons now requires screening for alcohol use in trauma centers. The purpose of this research study is to provide information about the best screening and treatment methods.
- Trial name
- TM (NCT00865774)
- Testing
- Quantity Frequency Model, Targets Subjective Drunkenness
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- Wake Forest University Health Sciences
Alcohol Dependence
Alcohol Consumption and Stress at Patients Alcohol-dependants
This 3 weeks study examines the correlation between stress and alcohol using an ecological, prospective design.
- Trial name
- CASPA (NCT02087358)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Dependence
A New Pharmacotherapy for Alcohol Dependence: Olanzapine
Craving for alcohol has been related to loss of control drinking and is a major target of biological and behavioral interventions for alcohol dependence.
- Trial name
- NCT00746785
- Testing
- 2.5 mg Olanzapine, 5mg Olanzapine
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- The Mind Research Network
Fetal Alcohol Syndrome
Prenatal Alcohol Biomarker Study in Uruguay
The purpose of this study is to examine the association between maternal alcohol use and newborn phosphatidylethanol (PEth) levels in their newborn.
- Trial name
- NCT02600624
- Where
- 2 sites in United States, Uruguay
- Volunteers
- 1,412 people
- Sponsor
- Northwestern University
Alcohol Use Disorder, Depression
The Network Study: Soldiers Connecting for Work and Health
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior in Soldiers as they transition from Active Duty into the civilian workforce as a Veteran.
- Trial name
- NCT04463225
- Testing
- Internet-Delivered Brief Intervention
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Cornell University
Alcohol Abuse
Web Intervention for Concerned Partners to Prevent Service Member Alcohol Abuse Abuse
The purpose of this study is to adapt and pilot-test a web-based intervention intended to help concerned partners provide support to service members with alcohol misuse and to begin development of a service member module based on…
- Trial name
- PC (NCT02073825)
- Testing
- Web Brief Intervention (WBI)
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- RAND
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