Clinical trials: Aldosteronism
Hypertension, Resistant to Conventional Therapy
Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China
Recent studies indicate that primary aldosteronism (PA) is a much more common cause of hypertension than had been demonstrated historically.
- Trial name
- NCT01459042
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Aldosteronism Due to Aldosterone Producing Adenoma
MRA and ARB Treatment in Screening of Primary Aldosteronism
Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA).
- Trial name
- EMIRA (NCT04185857)
- Testing
- canrenone 50-100 mg orally once a day, olmesartan 10-20 mg orally once a day
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Primary Aldosteronism
A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Primary Aldosteronism
This is a multicenter, randomized, double-blind, placebo-controlled phase II study designed to explore the efficacy and safety of different doses of SAL0140 in primary aldosteronism.
- Trial name
- NCT07646535
- Testing
- SAL0140 Tablets
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Primary Aldosteronism
Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas
This observational study tests the hypothesis that endogenous aldosterone impairs insulin secretion and insulin sensitivity in subjects with primary aldosteronism.
- Trial name
- NCT02362308
- Testing
- Adrenalectomy, mineralocorticoid receptor antagonist
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Rapid Cortisol Assay in Adrenal Vein Sampling
Background: Adrenal vein sampling (AVS) is the gold standard test for the subtyping of primary aldosteronism (PA). This procedure is hampered by unsuccessful bilateral cannulation of adrenal veins, which can occur in up to two…
- Trial name
- I-PADUA (NCT03449797)
- Testing
- AVS performed with no intraprocedural rapid cortisol assay, AVS performed plus intraprocedural rapid cortisol assay
- Volunteers
- 200 people
- Sponsor
- University Hospital Padova
Hyperaldosteronism, Hypertension
Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.
This study aims to evaluate the diagnostic value of the Aldosterone-Renin Ratio (ARR)as a screening test for primary aldosteronism among hypertensives. The test characteristics will be studied.
- Trial name
- NCT00407784
- Testing
- eplerenone
- Where
- 13 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Erasmus Medical Center
Primary Aldosteronism, Suprarenalectomy
Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy
The aim of this study was to compare the efficacy and safety of adrenalectomy and superselective adrenal artery embolization in a prospective, multicenter, randomized controlled study.
- Conditions
- Primary Aldosteronism, Suprarenalectomy, Super Selective Adrenal Artery Embolization
- Trial name
- PA-SELECT (NCT06513585)
- Testing
- Superselective adrenal artery embolization or adrenalectomy
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Xinjiang Medical University
Prostate Cancer
Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy
The purpose of the study is to determine the safety and clinical benefit of the combinations of abiraterone acetate and prednisone or abiraterone and dexamethasone in prostate cancer patients.
- Trial name
- NCT01867710
- Testing
- Abiraterone Acetate, Prednisone 5 mg twice daily, Prednisone 5 mg once daily
- Where
- 17 sites in Belgium, Germany and 2 more
- Volunteers
- 164 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism
Efficacy and Safety of Finerenone vs. Spironolactone in Patients With Primary Aldosteronism
To study the efficacy and safety of finerenone vs. spironolactone in patients with primary aldosteronism
- Trial name
- FAVOR (NCT06164379)
- Testing
- Finerenone, Spironolactone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Endocrine Disorders, Hypertension
EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders
The goal of this trial is to learn whether wearable devices and hormone sampling can measure how the body changes during daily-life challenges in adults with endocrine or metabolic disorders.
- Conditions
- Endocrine Disorders, Hypertension, Primary Aldosteronism, Cortisol Excess
- Trial name
- EndoSense (NCT07727356)
- Testing
- Sequential Dietary Sodium Modulation
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Felix Beuschlein
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Hyperaldosteronism, Conn Syndrome
Laparoscopic Adrenalectomy Versus Radiofrequency Ablation
This is a prospective randomized controlled study comparing laparoscopic adrenalectomy (LA) versus image-guided percutaneous radiofrequency ablation (RFA) in treating aldosterone-producing adenoma.
- Conditions
- Hyperaldosteronism, Conn Syndrome, Adrenocortical Adenoma
- Trial name
- LARFA (NCT02030587)
- Testing
- Radiofrequency Ablation, Laparoscopic Adrenalectomy
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Primary Aldosteronism
Comparison of Three Confirmatory Tests in the Diagnosis of Primary Aldosteronism
To compare the diagnostic value of three confirmatory tests for primary aldosteronism.
- Trial name
- NCT04193137
- Testing
- Oral sodium loading test,Seated saline infusion test and Captopril challenge test
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Primary Aldosteronism Due to Adrenal Hyperplasia
Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT
This multicenter randomized controlled trial plans to enroll primary aldosteronism (PA) patients who meet the following criteria: confirmed unilateral dominant secretion by adrenal vein sampling (AVS), willingness to undergo…
- Trial name
- GRAFT_PA (NCT07558811)
- Testing
- Intervention_1
- Volunteers
- 90 people
- Sponsor
- Ruijin Hospital
Primary Aldosteronism
Multi-omics Studies of Primary Aldosteronism
Primary aldosteronism is a prevalent yet underdiagnosed cause of secondary hypertension, contributing to significant cardiovascular morbidity and renal dysfunction.
- Trial name
- NCT07111351
- Testing
- Without intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Primary Aldosteronism, High Blood Pressure
Diagnosing Variable Primary Aldosteronism.
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
- Trial name
- NCT05765786
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Queen Mary University of London
Primary Aldosteronism
Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke
The guideline requires clinical works to screen for primary aldosteronism(PA) in young adults with family history of stroke at early onset.
- Trial name
- NCT04203420
- Testing
- screening and confirmatory tests
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Chongqing Medical University