Clinical trials: Aldosteronism, open to volunteers
Primary Aldosteronism
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.
The objective of this observational study is to utilize the advantages of 68Ga-Pentixafor subtyping diagnosis and the diagnostic ability of 68Ga-FAPI-04 for cardiovascular disease to identify primary aldosterone patients in need…
- Trial name
- NCT06756737
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Hypertension, Hyperaldosteronaemia
Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia
Elevated aldosterone causes moderate to severe increase in blood pressure, and leads to various target organ damage including cardiovascular ones.
- Trial name
- EMRACHH (NCT05688579)
- Testing
- Mineralocorticoid Receptor Antagonists(MRAs), Blank control
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Nanfang Li
Primary Aldosteronism, Suprarenalectomy
Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy
The aim of this study was to compare the efficacy and safety of adrenalectomy and superselective adrenal artery embolization in a prospective, multicenter, randomized controlled study.
- Conditions
- Primary Aldosteronism, Suprarenalectomy, Super Selective Adrenal Artery Embolization
- Trial name
- PA-SELECT (NCT06513585)
- Testing
- Superselective adrenal artery embolization or adrenalectomy
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism
Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism
The goal of this clinical trial is to find out whether treatment with baxdrostat changes aldosterone-producing activity in the adrenal glands of people with primary aldosteronism.
- Trial name
- EliXir (NCT07800858)
- Testing
- baxdrostat
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Mary University of London
Primary Aldosteronism
Comparing Inclisiran Versus Statin for Primary Aldosteronism
Primary aldosteronism represents one of the leading causes of resistant hypertension. Circulating cholesterol is established as the exclusive substrate for adrenal aldosterone synthesis, and statins, which suppress cholesterol…
- Trial name
- NCT07884955
- Testing
- inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Adrenal Tumor
Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors
The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.
- Conditions
- Primary Aldosteronism, Adrenal Tumor, Cushing s Syndrome, Pheochromocytoma/Paraganglioma (PPGL)
- Trial name
- NCT07182175
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Hypertension, Primary Aldosteronism
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy.
- Conditions
- Hypertension, Primary Aldosteronism, Hypokalemia
- Trial name
- SSTT (NCT06569589)
- Testing
- 23NaMRI Scan, Potassium Chloride (KCl)
- Where
- 4 sites in Singapore
- Volunteers
- 80 people
- Sponsor
- Jens Titze
Primary Aldosteronism, Autonomous Cortisol Secretion
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the…
- Trial name
- NCT06833437
- Testing
- 68Ga-Pentixafor PET/CT, AVS
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qifu Li
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma
This is a prospective, single-center, single-arm study evaluating endoscopic ultrasound-guided ethanol ablation for left-sided aldosterone-producing adenoma.
- Trial name
- CREATE (NCT07700472)
- Testing
- Endoscopic Ultrasound-Guided Ethanol Ablation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
- Trial name
- NCT06750172
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism, Statin
Statin Combined with Amlodipine Treats Primary Aldosteronism
The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1…
- Conditions
- Primary Aldosteronism, Statin, Mineralocorticoid Receptor Antagonist, Hypertension
- Trial name
- STOP-PA (NCT06523465)
- Testing
- Simvastatin combined with Amlodipine besylate, Simvastatin combined with Spironolactone and Amlodipine besylate., Amlodipine besylate combined Spironolactone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
The goal of this clinical trial is to investigate the uptake characteristics of [18F]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism.
- Trial name
- SPACE (NCT06616142)
- Testing
- [18F]CETO tracer, Dexamethasone oral, Adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Primary Aldosteronism, Cognitive Dysfunction
The Association Between Primary Aldosteronism and Cognitive Dysfunction
The goal of this observational study is to learn about the prevalence, progression, and influencing factors of cognitive impairment in patients with primary aldosteronism (PA). The main questions it aims to answer are: 1.
- Conditions
- Primary Aldosteronism, Cognitive Dysfunction, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- PACD (NCT07304674)
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism, Super Selective Adrenal Arterial Embolization
Super Selective Adrenal Artery Embolization for Primary Aldosteronism: a Prospective Cohort Study(SAAE-PA)
The objective of this study was to evaluate the efficacy and safety of adrenal vein blood extraction for primary aldosteronism classification and adrenal artery embolization in the treatment of primary aldosteronism, to provide…
- Trial name
- NCT06513676
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Hyperaldosteronism
China National Study of Adrenal Venous Sampling
This multicenter study intends to combine retrospective analysis and prospective registry to evaluate the success rate and safety of adrenal venous sampling (AVS) via antecubital and femoral approach for patients with primary…
- Trial name
- CNAVS (NCT06192238)
- Testing
- adrenal venous sampling
- Where
- 48 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Adrenal Adenoma, Cushing Syndrome
A Prospective Cohort Study for Patients With Adrenal Diseases
The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.
- Conditions
- Adrenal Adenoma, Cushing Syndrome, Pheochromocytoma, Adrenal Incidentaloma
- Trial name
- NCT03474237
- Testing
- Hormone study and Imaging study
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Multi-omics Studies of Primary Aldosteronism
Primary aldosteronism is a prevalent yet underdiagnosed cause of secondary hypertension, contributing to significant cardiovascular morbidity and renal dysfunction.
- Trial name
- NCT07111351
- Testing
- Without intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Post Operative Pain, Acute
Comparison of Needlescopic vs. Conventional Laparoscopic Adrenalectomy for Tumor Less Than 4 cm
The investigator conduct a randomized clinical trial for the needlescopic and conventional laparoscopic adrenalectomy to assess whether mini laparoscopic adrenalectomy is better than conventional laparoscopic adrenalectomy in…
- Trial name
- NCT05675124
- Testing
- Needlescopic laparoscopic adrenalectomy, conventional laparoscopic adrenalectomy
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- National Taiwan University Hospital
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)