Clinical trials: Allergic Rhinitis (Disorder)
Rhinitis
A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712)
The purpose of this study is to determine the onset of action of two commercially available over-the-counter antihistamines (Loratadine and Fexofenadine) in a model of seasonal allergic rhinitis (SAR).
- Trial name
- NCT01469234
- Testing
- loratadine, fexofenadine
- Volunteers
- 255 people
- Sponsor
- Bayer
Seasonal Allergic Rhinitis
Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis
This study will compare the PK parameters of the combination test formulation to monotherapy reference products (mometasone furoate and azelastine hydrochloride) in adolescents and young adult patients with seasonal allergic…
- Trial name
- NCT05887843
- Testing
- Mometasone + Azelastine, Mometasone Furoate, Azelastine Hydrochloride
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Sandoz
Allergic Rhinitis
Allergenic Extract Standardized Cat Hair AP in an Allergic Rhinitis Model.
The goal of this study is to learn if a cat allergen extract known as Allergenic Extract Standardized Cat Hair Acetone Precipitated (AP Cat) can induce allergic rhinitis (AR) in a nasal allergen challenge model in cat-allergic…
- Trial name
- AP-CAT (NCT06828484)
- Testing
- Allergenic Extract Standardized Cat Hair Acetone-Precipitated (AP)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Seasonal Allergic Rhinitis
Azelastine Allergen Chamber - Onset of Action Study
This study is to assess the Onset of Action and Efficacy of azelastine hydrochloride 0.15% in treating the nasal symptoms of seasonal allergic rhinitis (SAR) induced by an allergen challenge in an Environmental Exposure Unit…
- Trial name
- NCT06126952
- Testing
- Treatment A: Azelastine hydrochloride 0.15% nasal spray (Azelair), Treatment C: Ryaltris (Active Control) - mometasone furoate monohydrate and olopatadine hydrochloride nasal spray
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Allergic Rhinitis
Single Dose Crossover Study of Patient Preference for Unscented Nasonex® Nasal Spray Versus Scented Flonase® Nasal Spray (Study P04208)
This was a one-day single dose trial conducted to compare patient's preference for Nasonex® (mometasone) versus Flonase® nasal spray. Each patient was randomized to take one dose (2 sprays in each nostril) of Nasonex or Flonase.
- Trial name
- NCT00783458
- Testing
- Mometasone Furoate Nasal Spray, fluticasone nasal spray
- Volunteers
- 100 people
- Sponsor
- Organon and Co
Rhinitis, Allergic, Perennial, Asthma
Biomarker-based Cockroach Sublingual Immunotherapy Study (BioCSI)
There is currently no effective way to prevent development of allergic rhinitis (nasal allergies) and asthma and no cure. Sublingual immunotherapy (SLIT), a type of therapy in which allergens are placed under the tongue, may be a…
- Trial name
- NCT00829985
- Testing
- Glycerinated German Cockroach Allergenic Extract
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Seasonal Allergic Rhinitis
Reduction of IgE Antibody in Human Allergic Subjects
The purpose of this study is to determine whether a neuropeptide, substance P, when injected along with an allergen, such as ragweed, can reduce allergic reactivity.
- Trial name
- NCT01280149
- Testing
- substance P, substance P injections
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Allergic Asthma, Allergy to Cats
Airway Immune Response to Allergens (Use Lay Language Here)
Most asthma is allergic in origin. The purpose of this study is to better understand the airway immune response to inhaled allergens in order to identify factors that promote asthma.
- Conditions
- Allergic Asthma, Allergy to Cats, Allergy to Dust Mites, Allergic Rhinitis
- Trial name
- NCT04619017
- Testing
- Segmental allergen challenge
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- JOSALYN CHO
Seasonal Allergic Rhinitis
Comparison of the Effects of Desloratadine and Placebo in the Relief of Nasal Symptom Scores in Subjects With Seasonal Allergic Rhinitis to Cypress Pollen (Study P02836)
The purpose of this study was to demonstrate the efficacy (% of change from baseline) of desloratadine to improve the nasal total symptom score of SAR to cypress pollen.
- Trial name
- NCT00867191
- Testing
- Desloratadine
- Volunteers
- 233 people
- Sponsor
- Organon and Co
Rhinitis, Allergic Rhinoconjunctivitis
Dietary Supplement (Beta-Glucans) in Allergic Patients Undergoing Subcutaneous Immunotherapy.
The present study will attempt to determine if the dietary supplement, based on a synergistic combination of β-glucans and Saccharomyces cerevisiae yeast enriched with Zinc and Selenium, can improve the immune response in…
- Conditions
- Rhinitis, Allergic Rhinoconjunctivitis, Rhinoconjunctivitis, Controlled Asthma
- Trial name
- NCT06448585
- Testing
- Specific immunotherapy (SIT) treatment, Dietary Supplement: ABB C1, Mini-tablets with pork extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Gala Servicios Clinicos S.L.
Seasonal Allergic Rhinitis, SAR
A Phase III Study to Assess the Efficacy and Safety of PG-011 Nasal Spray in Adults With Moderate to Severe Seasonal Allergic Rhinitis
The study is a multicenter, randomized, double-blind, placebo-controlled seamless and adaptive-designed phase IIb/III study encompassing a phase IIb and a phase III component, phase IIb is a dose-ranging part and has been done…
- Trial name
- Pumecitinib (NCT07146126)
- Testing
- PG-011 nasal spray 0.6%(twice daily)
- Where
- 38 sites in China
- Volunteers
- 600 people
- Sponsor
- Prime Gene Therapeutics Co., Ltd.
Allergic Rhinitis
Effects of AkPharma's Calcium Glycerophosphate Nasal Spray Wash
Over 20 million Americans have allergic nasal symptoms including stuffiness, sneezing and a "runny" nose. AkPharma's Calcium Glycerophosphate used as a nasal spray wash is believed to improve these symptoms without side effects…
- Trial name
- NCT01647633
- Testing
- Calcium Glycerophosphate Nasal Spray Wash
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Drexel University
Allergic Rhinitis, Asthma
A Trial of Immunological Outcomes of Sublingual Immunotherapy for House Dust Mite (D. Pteronyssinus) Allergy
Allergic diseases represent a major health issue worldwide. Mainstay treatment is allergen avoidance and pharmacotherapy for symptom relief.
- Trial name
- NCT00250263
- Testing
- (agent for immunotherapy) Staloral
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Bayside Health
Perennial Allergic Rhinitis, Allergic Rhinitis
Safety and Effectiveness of Ciclesonide Nasal Spray in Children (6 to 11 Years) With Perennial Allergic Rhinitis (BY9010/M1-403)
The purpose of this study is to investigate the safety and effectiveness of ciclesonide nasal spray as compared with placebo (inactive substance) nasal spray in relieving symptoms of perennial allergic rhinitis.
- Conditions
- Perennial Allergic Rhinitis, Allergic Rhinitis, Hay Fever
- Trial name
- NCT00163514
- Testing
- Ciclesonide
- Where
- 74 sites in United States, Canada
- Volunteers
- 636 people
- Sponsor
- AstraZeneca
Seasonal Allergic Rhinitis
The Efficacy of Preseasonal Omalizumab Treatment
Allergic rhinitis (AR) is induced by an immunoglobulin E (IgE)-mediated reaction in the allergen-sensitized subjects, affecting 10% to 40% of the world population.
- Trial name
- NCT04489121
- Testing
- Omalizumab
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Beijing Tongren Hospital
Allergic Rhinitis
Confirmatory Study on the Efficacy and Safety of the Fixed-dose Combination of Desloratadine/Betamethasone Versus Desloratadine
Phase IIIb , longitudinal, multicenter, randomized, double-blind, to evaluate efficacy and safety of the fixed-dose combination of Desloratadine 5 mg / Betamethasone 0.25 mg versus Desloratadine 5 mg monotherapy as treatment for…
- Trial name
- DESCUBRA (NCT06916884)
- Testing
- Desloratadine / Betamethasone in fixed dose, Desloratadine
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Allergic Rhinitis
The Effect of Desloratadine and Levocetirizine on Nasal Obstruction (Study P03609)
This was a study to measure the ability of desloratadine and levocetirizine to decrease nasal obstruction in subjects who had study-induced allergic rhinitis.
- Trial name
- NCT00789152
- Testing
- desloratadine, levocetirizine
- Volunteers
- 81 people
- Sponsor
- Organon and Co
Allergic Rhinitis
3-D Visualization of the Anti-Obstructive Effect of Levocetirizine
The prevalence of allergic rhinitis is high and appears to be rising worldwide. Therefore, it is important and necessary to understand and visualize therapy effects on this disease.
- Trial name
- LevoNasalFlo (NCT01000792)
- Testing
- Levocetirizine
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Clinical Research International Limited
Allergic Rhinitis, Sinusitis
Harnessing Digital Medicine to Improve Allergic Rhinitis Management in Primary Care (DMAR)
This study aims to evaluate the effectiveness of digital tools in managing allergic rhinitis (AR) in primary care settings. AR is a common condition that affects many people's quality of life.
- Trial name
- DMAR (NCT06603935)
- Testing
- QHSLab Digital Tools (AME and ARIS)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- QHSLab, Inc.
Seasonal Allergic Rhinitis, Asthma
Safety Study of Ragweed-SPIRE in Subjects With Ragweed Allergies and Asthma
The purpose of this study is to determine whether it is safe to administer Ragweed-SPIRE to subjects suffering from both ragweed allergy and asthma.
- Trial name
- NCT02061670
- Testing
- Ragweed-SPIRE
- Where
- 5 sites in Canada
- Volunteers
- 55 people
- Sponsor
- Circassia Limited
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