Clinical trials: Allergic Rhinitis Due to Pollen
Allergic Asthma, Thunderstorm Asthma
Creating A Risk Assessment Tool for Thunderstorm Asthma: the CARISTA Study
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen.
- Conditions
- Allergic Asthma, Thunderstorm Asthma, Seasonal Allergic Rhinitis, Grass Pollen Allergy
- Trial name
- CARISTA (NCT07055542)
- Testing
- Observational
- Where
- 6 sites in Australia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Allergic Rhinitis Due to Grass Pollens
M-Gard Particulate EW Efficacy Study on Seasonal Allergic Rhinitis
The goal of this clinical trial is to assess the efficacy and safety of M-Gard supplementation for alleviating the symptoms of allergic rhinitis.
- Trial name
- NCT06907680
- Testing
- M-Gard
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Allergic Rhinitis Due to Pollen, Allergic Conjunctivitis
Tyrosine Allergoid Paediatric and Adult Study
The primary objective of this 5-year study is to demonstrate non-inferiority of children compared to adults by exploring long-term effectiveness after treatment with TA Bäume (trees) and TA Gräser (grass) following a perennial…
- Conditions
- Allergic Rhinitis Due to Pollen, Allergic Conjunctivitis, Allergic Asthma
- Trial name
- NCT05186025
- Testing
- MATA trees or MATA grass
- Where
- Germany
- Volunteers
- 320 people
- Sponsor
- Allergy Therapeutics
Allergic Rhinitis Due to Weed Pollen, Allergic Rhinitis
Trial of INI-2004 in Healthy Volunteers and Participants With Allergic Rhinitis.
This is a Phase I/Ib, randomised, double-blind, placebo-controlled study of INI-2004, administered as single or multiple doses. This study will be conducted in two parts: Phase I single ascending dose (SAD) and Phase Ib multiple…
- Trial name
- NCT06038279
- Testing
- INI-2004
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Inimmune Corporation
Allergic Rhinitis Due to Pollen
Nasal Allergen Challenge Test as a Method to Detect Clinical Reactivity Against Birch Pollen
Clinical efficacy and tolerability for allergen specific immunotherapy (AIT) with Itulazax (birch pollen extract tablet) is well established.
- Trial name
- NAC (NCT06085963)
- Testing
- ITULAZAX 12 SQ-Bet, Nacl
- Where
- Sweden
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Allergic Rhinitis Due to Grass Pollen, Allergic Conjunctivitis of Both Eyes
Documentation of Efficacy of Intralymphatic Allergen Immunotherapy
Investigation of the clinical efficacy of 3 intralymphatic injections with grass pollen extract into inguinal lymph nodes on combined symptom-medication scores during grass pollen season in grass pollen allergic patients compared…
- Conditions
- Allergic Rhinitis Due to Grass Pollen, Allergic Conjunctivitis of Both Eyes, Allergic Asthma
- Trial name
- ILITNU (NCT05191186)
- Testing
- Grass pollen extract - Alutard Phleum pratense, ALK
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 450 people
- Sponsor
- Aarhus University Hospital
Rhinitis, Allergic, Seasonal, Rhinitis; Allergic, With Asthma
Intralymphatic Immunotherapy With Polvac Grass & Rye Allergen Extract
The primary goal is to investigate the efficacy of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis and allergic asthma due to sensitisation to grass pollen allergens.
- Conditions
- Rhinitis, Allergic, Seasonal, Rhinitis; Allergic, With Asthma, Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen
- Trial name
- NCT05297760
- Testing
- Polvac Grass+Rye, Saline 0.9%
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Allergic Rhinitis Due to Grass Pollen
Intralymphatic Immunotherapy Enhanced by Vitamin-D, a Randomized Placebo-controlled Trial and Comparison With SLIT
A national, multicenter, randmised double blind study with parallell arms. 360 patients with grass induced allergic rhinitis will be open randomised 1:2 to 3 years Grazax sublingual immunotherapy or 3 intralymphatic injections…
- Trial name
- ILIT vs SLIT (NCT06061848)
- Testing
- SLIT Grazax ALK Nordic 75 000 SQ-T, ILIT + Vitamin D
- Where
- 3 sites in Sweden
- Volunteers
- 360 people
- Sponsor
- Lars Olaf Cardell
Allergic Rhinitis Due to Grass Pollen
Determination of Grass Pollen Allergen Concentration Inducing Rhinoconjunctivitis Symptoms in Subjects Allergic to Grass Pollen in ALYATEC Allergen Exposure Chamber
The aim of this study is to determine the optimal concentration of grass pollen allergens inducing rhinoconjunctivitis in subjects allergic to grass pollen in ALYATEC allergen exposure chamber.
- Trial name
- NCT06104293
- Testing
- Grass Pollen Allergen Exposure
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Alyatec
Allergic Rhinitis Due to Pollen, Allergic Rhinitis With Asthma
Interaction Between Air Pollution, Pollens and Allergic Rhinitis
Seasonal allergic rhinitis has multiple consequences: sleep disturbances, fatigue, depressed mood, impaired quality of life and productivity, and co-morbid conditions such as asthma, which affects one third of AR patients.
- Trial name
- MISTRAL (NCT05007327)
- Testing
- Exposure to pollen and air pollution
- Where
- France
- Volunteers
- 1,215 people
- Sponsor
- MASK-air SAS
Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis
This is a Prospective, Controlled, Double Blinded, Single Center, Randomized, 3 Arm, Parallel Assignment, Phase 1b/2a Study to assess the safety, tolerability, and preliminary efficacy of B244 delivered as an intranasal spray in…
- Conditions
- Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen, Healthy Volunteers
- Trial name
- NCT03290248
- Testing
- B244 suspension, Vehicle
- Where
- 2 sites in United States, Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
Allergic Rhinitis Due to Grass Pollen
The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells
The aim of the study is to assess the effect of polyvalent mechanical bacterial lysate (PMBL, Ismigen) on the clinical course of grass pollen-induced allergic rhinitis (using: total nasal symptom score, visual analogue scale…
- Trial name
- NCT04802616
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lublin
Allergic Rhinitis Due to Grass Pollen
ILIT: Follow-up of Rhinitis Quality of Life
Re-evaluation of patients treated with intralymphatic immunotherapy (ILIT) in terms of quality of life and therapeutic efficacy and comparison with subcutaneous immunotherapy (SCIT) 15 years post immunotherapy
- Trial name
- NCT05037955
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Zurich
Allergic Rhinitis Due to Weed Pollen, Montelukast
Early Intervention in Allergic Patients
As many as 250 million people suffer from allergic rhinitis in China, which has a large population, early use of drugs may help better control the symptoms.This study aimed to investigate the effects of early interventional…
- Trial name
- NCT05040828
- Testing
- Start taking Montelukast Sodium Tablets 10mg quaque die orally two weeks before peak pollen count., Montelukast Sodium Tablets 10mg quaque die orally was administered after peak pollen count., No oral drug therapy throughout the pollen period
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Beijing Tongren Hospital
Allergic Rhinitis Due to Grass Pollen, Allergic Asthma
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation
IgE-associated allergy is a hypersensitivity disease affecting more than 40% of the population in industrialised countries. Recently the kinetics of change of clinical and immunological parameters (e.g.
- Trial name
- NCT04878237
- Testing
- Nasal Secretion Sampling
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Allergic Rhinitis Due to Tree Pollen, Allergic Conjunctivitis
Texan Allergy & Sinus Center Mountain Cedar Intra-Lymphatic Immunotherapy Study
TX-SMILE is an investigator-initiated, multi-center, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy, safety, and tolerability of intra-lymphatic administration of an approved…
- Conditions
- Allergic Rhinitis Due to Tree Pollen, Allergic Conjunctivitis, Allergic Rhinoconjunctivitis
- Trial name
- TX-SMILE (NCT03682965)
- Testing
- Intra-lymphatic allergenic extract
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Christopher Thompson, MD
Allergic Rhinitis Due to Grass Pollen, Allergic Inflammation
Efficacy of Puressentiel Protective Nasal Spray in Allergic Rhinitis
This study is a proof o concept aiming to determine the efficacy of Puressentiel nasal protective spray (PNPS) in patients with allergic rhinitis.
- Trial name
- EPPNS (NCT04700852)
- Testing
- Puressentiel protective nasal spray
- Volunteers
- 15 people
- Sponsor
- Puressentiel
Allergic Rhinitis Due to Grass Pollen
Is Intralymphatic Allergen Immunotherapy Effective and Safe?
15 patients with moderate to severe allergic rhinitis against grass were recruited and enrolled in the study. They received three open label intralympatic grass allergen injections with the dose 1000 SQ-U each and with one month…
- Trial name
- NCT04210193
- Testing
- ALK Alutard 5-grasses, ALK Diluent
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Lars Olaf Cardell
Allergic Rhinitis Due to Grass Pollens
Molecular and Cellular Mechanism in the Course of Immunotherapy With a Phleum Pratense Oral Lyophilisate
This trial is an exploratory randomised, parallel-group, double-blind, placebo- controlled, national, single-centre trial. The trial will be initiated before 2013 grass pollen season and subjects will be randomised in September…
- Trial name
- NCT01854736
- Testing
- Grazax
- Where
- 2 sites in Spain
- Volunteers
- 51 people
- Sponsor
- ALK-Abelló A/S
Allergic Rhinitis Due to Grass Pollen
Prospective Observational Study for Determination of Minimal Clinically Important Difference of Allergic Rhinitis Symptoms Due to Grass Pollen (Equinoxe 2)
Prospective multi-center study carried out in France involving patients with allergic rhinitis. Study in usual care where no specific diagnostic or therapeutic procedure is required.
- Trial name
- NCT01953471
- Testing
- Allergic rhinitis
- Where
- France
- Volunteers
- 959 people
- Sponsor
- Hopital Foch