Clinical trials: Allergy
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Allergic Conjunctivitis
Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy Volunteers
This study is being conducted to evaluate the safety of KetoNaph ophthalmic solution in healthy adult subjects and in pediatric subjects with a history or family history of ocular allergy.
- Trial name
- NCT01159015
- Testing
- KetoNaph, Vehicle
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Asthma
A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283
The purpose of this study is to compare how two different formulations of the study medicine (GSK5784283) move through the body over time (pharmacokinetic [PK] study) in healthy adults.
- Trial name
- NCT07712393
- Testing
- GSK5784283
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anaphylaxis, Hypoxia
Virtual Reality-Based Simulation Versus High-Fidelity Simulation for Emergency Management Training in Medical Interns
This study is a two-arm parallel randomized controlled non-inferiority trial designed to compare the educational effectiveness of virtual reality (VR)-based simulation with high-fidelity simulation (HFS) for emergency management…
- Trial name
- NCT07584863
- Testing
- Virtual Reality-Based Emergency Simulation, High-Fidelity Simulation
- Where
- South Korea
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Allergic Conjunctivitis
A Six-Week Safety Study of an Investigational Ophthalmic Solution
The purpose of this study was to evaluate the ocular safety of an investigational ophthalmic solution in subjects 2 years of age and older with asymptomatic eyes when administered once daily in both eyes for up to 6 weeks.
- Trial name
- NCT01698814
- Testing
- AL-4943A Ophthalmic Solution, AL-4943A Ophthalmic Solution Vehicle
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Skin, Sensitive Skin
Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women
This clinical study aims to determine whether taking two different doses of collagen-derived peptides for three months improves facial skin barrier integrity in women with dry, sensitive skin, compared with a placebo.
- Conditions
- Dry Skin, Sensitive Skin, Dry Skin in the Elderly, Dietary Supplement
- Trial name
- NCT07529249
- Testing
- Investigational Product 1, Investigational Product 2
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Centre de Pharmacologie Clinique Applique a la Dermatologie
Asthma
Study to Look at and Compare How Inhaled and Intravenous Fluticasone Furoate and GW642444 Are Processed by the Body in Healthy Subjects
This study is being done to look at the absolute bioavailability of fluticasone furoate and GW642444 inhalation powder when administered in healthy subjects.
- Trial name
- NCT01299558
- Testing
- fluticasone furoate//GW642444, fluticasone furoate, GW642444
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cough, Upper Respiratory Tract Infections
Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients with Upper Respiratory Tract Infections
The goal of this mechanism of disease study is to investigate the effect of flurbiprofen, a non-steroidal anti-inflammatory drug (NSAID), on the cough hypersensitivity associated with upper respiratory tract infections (URTI).
- Trial name
- NCT05955885
- Testing
- Flurbiprofen Oral Lozenge, Difflam, Flurbiprofen 8.75 MG
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Overweight and Obesity, Insulin Sensitivity
Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and that this improvement can be measured in all men, not…
- Trial name
- HOTAIR3 (NCT02136615)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Acute Lymphoblastic Leukemia
Forecasting Hypersensitivity Against PEG-asparaginase to Optimize Outcome in ALL
Asparaginase is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). Clinical hypersensitivity reactions and PEG-asparaginase inactivation is common (12-13% of the patients on the NOPHO (Nordic Society for…
- Trial name
- NCT06195735
- Where
- Denmark
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dentin Sensitivity
Dentine Hypersensitivity Management KAP Study
The study aims to assess and compare the knowledge, attitudes, and practices of Egyptian and Nigerian dentists on etiology, diagnosis, and management of DH.
- Trial name
- NCT06582238
- Testing
- Dentists in Clinical Practice
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Muhammad Modu
Carious Lesion
Efficacy of Nanoparticle-incorporated Bonding Agent on Post-restorative Sensitivity
Type of study: Randomized Clinical trial To compare post-restorative sensitivity between titania nanoparticle reinforced bonding agent and bonding agent without nanoparticles in posterior composite restorations.
- Trial name
- NCT05744648
- Testing
- Composite resin restoration using Titania nanoparticle reinforced bonding agent, Composite resin restoration without Titania nanoparticle incorporated bonding agent
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Asthma, COPD
A Clinical Study in Healthy Subjects to Evaluate 9MW1911 Injection
This is a Phase 1, randomized, placebo-controlled study, enrolling approximately 38 healthy adult subjects (18-65 yrs). The purpose of this study is to evaluate the safety, tolerability and PK of single ascending dose of 9MW1911…
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05170243
- Testing
- 9MW1911 Injection
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Pulse Spectrum Analysis, Pulmonary Function
Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath Condensate
Our hypothesis is that radial arterial pulse may reflect the severity and airway function in asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery in adult asthmatics, and evaluate its…
- Conditions
- Pulse Spectrum Analysis, Pulmonary Function, FeNO, Metabolites
- Trial name
- NCT01719393
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Human Volunteers With Visibly Tanned Skin
A Proof-of-Concept, Safety and Efficacy Study of SkinQ Glow Bright Wonder Mask in Healthy Human Subjects
This is an open-label, single-arm, single-centre, proof-of-concept, safety and efficacy, clinical study of SkinQ Glow Bright Wonder Mask in Healthy Human Subjects and adequate representation of varied skin types [Normal, Oily…
- Trial name
- NCT05499247
- Testing
- SkinQ Glow Bright Wonder Mask
- Where
- India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Atopic Immunoglobulin E-Mediated Allergic Disorder
A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy
The primary objective of this study is to assess the safety and tolerability of STMC-103H compared to placebo in allergic subjects who are otherwise healthy.
- Trial name
- NCT03819881
- Testing
- STMC-103H
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Siolta Therapeutics, Inc.
Asthma
Pharmacokinetic Study Comparing Salmeterol/Fluticasone Easyhaler and Seretide Diskus
Pharmacokinetic study comparing Salmeterol/fluticasone Easyhaler products and Seretide Diskus 50/500 µg/inhalation; a randomised, open, single centre, single dose, crossover study in healthy subjects
- Trial name
- NCT03060044
- Testing
- Salmeterol/fluticasone Easyhaler, Salmeterol/fluticasone Easyhaler with charcoal, Seretide Diskus
- Where
- Finland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Asthma
A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population
Asthmatic patients and non-asthmatic controls were recruited prospectively from four referral hospitals in Korea. Participants were challenged with each of methacholine and mannitol inhalation on different days.
- Trial name
- NCT02104284
- Testing
- methacholine and mannitol bronchial challenge tests
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- BL&H Co., Ltd
Dentin Sensitivity
Propolis in Reducing Dentin Hypersensitivity
Objective: This randomized, double-blind, parallel, placebo-controlled clinical trial aims to evaluate the effect of propolis with two distinct concentrations (10% and 15%), and the impact on volunteers' quality of life.
- Trial name
- NCT05083052
- Testing
- Propolis 15%, Propolis 10%
- Where
- Brazil
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Asthma
The Use of the Propeller Health Platform to Improve Inhaled Corticosteroid (ICS) Use Among Adults With Uncontrolled Persistent Asthma
This is a behavioral randomized controlled trial of adults with uncontrolled persistent asthma that tests if the Propeller Health sensor, mobile application, and dashboard can improve adherence to ICS.
- Trial name
- NCT03860519
- Testing
- Electronic Medication Monitors on ICS and SABA - Active Mode, Electronic Medication Monitors on ICS and SABA - Silent Mode, Asthma App Tracking of ICS/SABA Usage - Active Mode
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
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