Clinical trials: Allergy Wheat
Non-celiac Gluten Sensitivity, Wheat Intolerance
Bread Study: Comparison of the Tolerance of Spelt and Wheat Bread
This project aims to verify the hypothesis that spelt products are more tolerable than bread wheat products in a target group of individuals with self-diagnosed wheat sensitivity.
- Trial name
- NCT04401956
- Testing
- bread
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Food Allergy
Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy
This study is researching an experimental drug called linvoseltamab combined with another drug called dupilumab. The study is looking at patients who have severe IgE-mediated food allergy.
- Trial name
- NCT06369467
- Testing
- linvoseltamab, dupilumab
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- Regeneron Pharmaceuticals
Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome)
NCWS or IBS/FD in Relatives of CD Patients
Over 50% of non-celiac wheat sensitivity (NCWS) patients are HLA DQ2/DQ8 positive and often have a Celiac Disease (CD) family history.
- Conditions
- Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome), Functional Dyspepsia, Celiac Disease
- Trial name
- NCT07584473
- Testing
- Wheat-Free Diet
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- University of Palermo
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Non-celiac Wheat Sensitivity
Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03022513
- Testing
- Gluten free diet
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- University of Palermo
Celiac Disease, Wheat Hypersensitivity
Changes in Intestinal Permeability 4 Hours After Gluten Challenge
This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.
- Conditions
- Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy
- Trial name
- NCT03288831
- Testing
- Gluten
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wheat Allergy, Children
Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care
Wheat allergy is increasing in Thailand. Some studies show that cutaneous exposure of allergen may cause allergy and there are many wheat containing skin care products that are over-the-counter.
- Trial name
- NCT04013763
- Testing
- wheat containing skin care products
- Where
- Thailand
- Volunteers
- 7 people
- Sponsor
- Mahidol University
Non-celiac Wheat Sensitivity
Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03017274
- Testing
- Abdominal ultrasound examination
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Non-celiac Wheat Sensitivity
Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients
In the last few years a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or…
- Trial name
- NCT03008252
- Testing
- Lactose breath test, DBPC cow's milk protein challenge
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Palermo
Not-celiac Gluten Sensitivity
Diagnostic Significance of Positive EmA Antibodies in the Duodenal Culture Medium of Not-Celiac Wheat Sensitivity (NCWS)
The most frequent diseases caused by wheat ingestion are T cell-mediated disorders, i.e. celiac disease and immunoglobulin E (IgE)-mediated allergic reactions.
- Trial name
- NCWS (NCT02203201)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Non-celiac Wheat Sensitivity
Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03022994
- Testing
- Duodenum and rectum examination
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Palermo
Non-celiac Wheat Sensitivity
KIR Genes and Non-Celiac Wheat Sensitivity
Non-celiac gluten sensitivity (NCGS) is a condition characterized by gastrointestinal and extraintestinal symptoms which are triggered by gluten ingestion in the absence of celiac disease (CD) and wheat allergy.
- Trial name
- NCT05469971
- Testing
- KIR genotyping
- Where
- 4 sites in Italy
- Volunteers
- 170 people
- Sponsor
- University of Palermo
Wheat Allergy
Oral Desensitization to Wheat in School Aged Children
The aim of the study is to induce tolerance to wheat in wheat allergic children via oral desensitization therapy. The hypothesis is that oral administration of wheat with increasing dosing will increase the individual threshold…
- Trial name
- NCT01755884
- Testing
- Wheat oral immunotherapy
- Where
- 4 sites in Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Non-celiac Wheat Sensitivity
Self-reported Non-celiac Wheat Sensitivity (NCWS) in Patients Undergoing Digestive Endoscopy
Self-reported food hypersensitivity is common, particularly in women, with a reported prevalence of about 20% in the UK community.
- Trial name
- NCT04154137
- Testing
- Questionnaire
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Palermo
Occupational Asthma
Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests
Occupational asthma (OA) caused by high molecular weight (HMW) substances have been shown to induce predominantly an eosinophilic inflammation.
- Trial name
- NCT01783873
- Testing
- standardized bronchial challenge test (SCL SCL • • GenaSOL ™ GenaSIC ™)
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Strasbourg, France
Allergy;Food, Allergy Wheat
Food Challenge With Barley Starch as Active Comparator
Aim of the present study is to verify in a double-blind placebo controlled food challenge (DBPCFC) test that highly purified barley starch ingredient do not cause allergic reaction in subjects most potential to get allergic…
- Trial name
- BALA (NCT03352856)
- Testing
- Barley starch, Maize starch
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lyckeby Starch AB
Non-celiac Wheat Sensitivity
Osteoporosis In Non-Celiac Wheat Sensitivity Patients
Non-celiac gluten sensitivity (NCGS) or 'wheat sensitivity' (NCWS) is included in the spectrum of gluten-related disorders. No data are available on the prevalence of low bone mass density (BMD) in NCWS.
- Trial name
- NCT02421783
- Where
- 2 sites in Italy
- Volunteers
- 270 people
- Sponsor
- University of Palermo
Wheat Allergy
Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy
This is an observational pilot study investigating the effectiveness, safety and specific immunological mechanisms of Specific Oral Tolerance Induction (SOTI) in children with IgE-mediated wheat allergy.
- Trial name
- NCT03352193
- Testing
- Wheat spaghetti
- Where
- Greece
- Volunteers
- 15 people
- Sponsor
- Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
Wheat Allergy
Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study
Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5…
- Trial name
- NCT01070368
- Testing
- Commercial extract and in-house wheat extract
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy
A Phase 1 Study of Cizutamig in IgE Mediated Diseases
The purpose of this study is to evaluate the pharmacodynamics, safety, tolerability, pharmacokinetics, and immunogenicity of cizutamig in IgE Mediated Diseases.
- Conditions
- IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy, IgE-Mediated Cow Milk Allergy
- Trial name
- NCT07408869
- Testing
- Cizutamig
- Where
- Australia
- Sponsor
- Candid Therapeutics