Clinical trials: Allodynia
Hyperalgesia, Pain
Effect of High Dose Naloxone on Secondary Hyperalgesia
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Hyperalgesia, Pain, Naloxone, Opioid Antagonist
- Trial name
- NCT01935206
- Testing
- Naloxone (2 mg/kg)
- Where
- 2 sites in Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Hyperalgesia
Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models
MOR-NRI like Tapentadol are expected to reduce signs and symptoms of central sensitisation besides effectively reducing pain intensity in pain.
- Conditions
- Pain, Hyperalgesia, Allodynia
- Trial name
- NCT01615510
- Testing
- Tapentadol immediate release
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Healthy
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
N,N-dimethyltryptamine (DMT) is a classical psychedelic with similar effects like LSD or psilocybin. Preliminary evidence from case series and small open-label trials suggests that psychedelics may be promising candidates for the…
- Trial name
- DPS (NCT06180759)
- Testing
- Intravenous infusion of DMT, Intravenous infusion of ketamine
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Hyperalgesia
Influence of Genetics in Pain Sensitivity
The purpose of this study is to learn more about the role of genetics in pain sensitivity. Pain perception varies widely among individuals, and information gained from this trial may lead to better methods of preventing and…
- Conditions
- Healthy, Hyperalgesia, Pain
- Trial name
- NCT00001956
- Testing
- Blood draw, Oral surgery, Tissue biopsy
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pain Perception, Secondary Hyperalgesia
Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
This exploratory study is to improve an established pain model by a new stimulation profile that allows preferential activation of C fibers that are of main clinical interest in chronic pain and also to generate a stable…
- Trial name
- NCT05440266
- Testing
- Study Intervention: 25 ms half-sine wave stimulation, Control Intervention: 500 µs rectangular shaped stimulation
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Hyperalgesia
Positron Emission Tomography to Measure Pain and Pain Control
This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli.
- Conditions
- Healthy, Hyperalgesia, Pain, Peripheral Nervous System Disease
- Trial name
- NCT00001307
- Testing
- Oxygen-15 Water, Capsaicin
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Acute Pain
Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults
This study is to investigate the effect of open-label placebo (OLP) application on acute pain in an experimental model of acute pain (simulating wound pain: this installation will apply monophasic, rectangular electrical pulses…
- Trial name
- BOLPAP (NCT05819476)
- Testing
- OLP-injection, Scripted Evidence-based treatment rationale, Experimental model of acute pain
- Where
- Switzerland
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain Sensation, Hyperalgesia
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.
- Conditions
- Pain Sensation, Hyperalgesia, Allodynia
- Trial name
- CANAB I (NCT03985995)
- Testing
- CBD 800 mg p.o
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Complex Regional Pain Syndrome, Peripheral Nerve Injuries
Somatosensory Assessment and Rehabilitation of Allodynia (SARA)
This pilot study will test a new therapy, somatosensory rehabilitation, for the painful sensitivity experienced by persons with nerve injuries and/or complex regional pain syndrome (CRPS).
- Conditions
- Complex Regional Pain Syndrome, Peripheral Nerve Injuries, Hand Fractures
- Trial name
- SARA (NCT02070367)
- Testing
- Somatosensory rehabilitation, Usual treatment: physiotherapy
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Healthy
Trial Investigating the Characteristics of Knismesis - a Lever to Explore Allodynia in Neuropathic Pain
Also known as a "moving itch", knismesis is a mildly annoying sensation caused by a light movement on the skin, such as from a crawling insect. Its underlying mechanism rely on spatial summation, i.e.
- Trial name
- TICKLE (NCT04621747)
- Testing
- Battery of neurophysiological explorations
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Neuropathic
Gabapentin and Donepezil Combination on Experimental Human Pain Models
This study will compare the effects of gabapentin alone, and gabapentin + donepezil given together in two types of experimental electrical pain tests in up to 48 healthy male subjects (after 24 recruited in the first cohort an…
- Trial name
- NCT01485185
- Testing
- Gabapentin lower dose, Donepezil, Gabapentin higher dose
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Low Back Pain
Assessment of LTP-like Pain Amplification in Chronic Low Back Pain Patients
The present study is aimed to assess the LTP-like pain amplification in chronic low back pain patients to explore the central and peripheral effect for pain LTP.
- Trial name
- NCT03362827
- Testing
- Chronic low back pain patients, Subjects without chronic low back pain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Hyperalgesia, Allodynia
Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers
Our goal is to demonstrate that healthy volunteers treated with fenobam will develop a significantly reduced area of cutaneous hyperalgesia compared to volunteers treated with placebo, after exposure to the heat/capsaicin model…
- Trial name
- NCT01981395
- Testing
- Fenobam
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Laura Cavallone
Migraine With Aura, Migraine Without Aura
Can DFN-15 Terminate Migraine With Allodynia?
The majority of migraineurs seeking secondary or tertiary medical care develop cutaneous allodynia during the course of migraine, a sensory abnormality mediated by sensitization of central trigeminovascular neurons in the spinal…
- Conditions
- Migraine With Aura, Migraine Without Aura, Allodynia
- Trial name
- NCT03472378
- Testing
- DFN-15
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Healhty
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect).
- Trial name
- MDPS (NCT07494214)
- Testing
- MDMA 25 mg, MDMA 75 mg, MDMA 125 mg
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Symptomatic Irreversible Pulpitis, Acute Apical Periodontitis of Pulpal Origin
The Effect of Central Sensitization on Assessment Capacity of Patients
the aim of this study is to evaluate the effect of dental hyperalgesia and mechanical allodynia on the assessment capacity of individuals in a local Turkish population.
- Trial name
- NCT03553641
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Acute Nociceptive Pain, Hyperalgesia
Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults
Prospective, randomized, placebo-controlled, double-blinded, crossover study to investigate the effect of cannabidiol (CBD) on remifentanil-induced hyperalgesia in healthy volunteers in a well-established acute pain model.
- Conditions
- Acute Nociceptive Pain, Hyperalgesia, Allodynia, Opioid-induced Hyperalgesia
- Trial name
- CANAB II (NCT04059978)
- Testing
- CBD, Remifentanil
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Peripheral Neuropathic Pain, Nociceptive Pain
Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers
The purpose of this study is to investigate the effect of AZD3161 on mechanical pain sensitivity and axon reflex flare in normal and ultraviolet C irradiated skin.
- Trial name
- NCT01240148
- Testing
- AZD3161, Lidocaine
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pain
The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00657358
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Analgesia
The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
1. Introduction Paracetamol, an analgesic prescribed daily, has been in use for more than 50 years. Surprisingly, its mode of action is still unclear.
- Trial name
- NCT00970450
- Testing
- Paracetamol, Tropisetron
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland