Clinical trials: Alpha-Tocopherol
Smoking
Oxidative Stress and Vitamin E Requirements
The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements.
- Trial name
- NCT00067899
- Testing
- Vitamin E with and without Vitamin C
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Beta Thalassemia Major Anemia, Hemolysis
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia.
- Conditions
- Beta Thalassemia Major Anemia, Hemolysis, Oxidative Stress
- Trial name
- NCT03948737
- Testing
- Alpha-Tocopherol
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Asthma
Safety Study of a Vitamin E Supplement in Normal Volunteers and Those With Both Allergy and Asthma
Gamma tocopherol (gt) is a naturally occurring form of vitamin E that is found in many foods, and is also commercially available as a vitamin supplement.
- Trial name
- NCT00386178
- Testing
- Vitamin E supplement rich in gamma tocopherol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dry Eye Syndromes
Treatment of Dry Eye With Supplements
Dry eye syndrome (DES) is a highly prevalent ocular condition inducing an inflammatory response on the ocular surface. Common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential…
- Trial name
- NCT01364311
- Testing
- Vitamac® Tag and Nacht capsules
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Asthma
The Role of Vitamins E and C in Maintaining Lung Health in People With Asthma
This study will determine if airway antioxidant levels in allergic asthmatics are enhanced with a combination of vitamin E and vitamin C therapy.
- Trial name
- VITAS (NCT00142610)
- Testing
- Vitamin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Type 2 Diabetes
Ability of Almonds to Improve Nutrition During GLP-1 Treatment
This 8-week randomized controlled pilot trial is to test the hypothesis that, compared to a Usual Diet control group, almond intake will increase vitamin E (alpha-tocopherol) levels in the blood and improve diet quality (Healthy…
- Trial name
- NCT07796204
- Testing
- Almond Diet
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Pennington Biomedical Research Center
Carpal Tunnel Syndrome
A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) is a common condition that causes numbness, tingling, pain, and weakness in the hand due to compression of the median nerve at the wrist.
- Trial name
- NCT07312123
- Testing
- Alpha-Lipoic Acid, Vitamin E, and Vitamin B Complex, Combination Vitamin B1,B6,B12
- Where
- Malaysia
- Volunteers
- 84 people
- Sponsor
- Hospital Universiti Sains Malaysia
Colorectal Cancer
Vitamin E Supplements in Treating Patients Undergoing Surgery for Colorectal Cancer
RATIONALE: Vitamin E may help prevent the development of cancer. Studying samples of tissue from patients with colorectal cancer who receive Vitamin E before undergoing surgery in the laboratory may help doctors learn more about…
- Trial name
- NCT00905918
- Testing
- vitamin E, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rutgers, The State University of New Jersey
Drug Toxicity, Lung Cancer
13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer
RATIONALE: 13 Cis retinoic acid may prevent the development of cancer cells. PURPOSE: Randomized double-blinded phase II trial to study the effectiveness of 13-cis retinoic acid with or without vitamin E for chemoprevention or…
- Trial name
- 13-Cis (NCT00002586)
- Testing
- 13-cis retinoic acid, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Colorado, Denver
Lipid Metabolism Disorders
Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic Hyperlipidemia
Background: Obesity is known to lead to diseases such as diabetes and high cholesterol (or fats) in the blood (hyperlipidemia). But no one knows why.
- Trial name
- NCT07715890
- Testing
- High fat liquid shake
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Inflammation, Oxidative Stress
Antioxidants Combined With Cryotherapy on Inflammatory Response After Resistance Exercise in Untrained Volunteers
Acutely resistance exercise induces inflammatory responses and leukocytosis arising of oxidative stress, that clinically manifested by pain and/or delayed onset muscle soreness (DOMS).
- Conditions
- Inflammation, Oxidative Stress, Pain
- Trial name
- NCT02902315
- Testing
- Cryotherapy, Vitamins C and E, Vitamins C and E associated with cryotherapy
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Alzheimer's Disease
A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease
The purpose of this study is to determine whether alpha-tocopherol, memantine (Namenda), or the combination will significantly delay clinical progression in mild to moderately demented patients with Alzheimer's disease compared…
- Trial name
- TEAM-AD (NCT00235716)
- Testing
- dl-alpha-tocopherol, Memantine
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 613 people
- Sponsor
- US Department of Veterans Affairs
Stroke, Diabetes Mellitus
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
The project is a passive follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort. Originally, this was a large, randomized, double-blind, placebo-controlled, 2x2 factorial primary prevention trial…
- Conditions
- Stroke, Diabetes Mellitus, Heart Disease, Cancer
- Trial name
- NCT00342992
- Where
- Finland
- Volunteers
- 29,133 people
- Sponsor
- National Cancer Institute (NCI)
Burn
Vitamin E Supplementation in Burned Patients
A dietary antioxidant, alpha-tocopherol, will be used to potentially attenuate Vitamin E short- and long-term losses in plasma and adipose, reverse the oxidative stress of burn injury and, in the process, decrease the secondary…
- Trial name
- NCT01749371
- Testing
- Vitamin E
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Allergic Rhinitis, Mild Asthma
Effect of House Dust Mite Allergen Challenge in Persons Using 1200 mg Gamma Tocopherol Supplements
Twenty, house dust mite (HDM)-allergic non-smoking subjects with or without mild asthma between the ages 18-50 will be recruited. The primary endpoint will be nasal eosinophilia.
- Trial name
- MiteE (NCT00466596)
- Testing
- Gamma Tocopherol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alzheimer's Disease
Anti-Oxidant Treatment of Alzheimer's Disease
The purpose of this study is to examine the safety and effectiveness of two anti-oxidant treatment regimens in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00117403
- Testing
- Vitamin E, Vitamin C, and Alpha-lipoic Acid, Coenzyme Q
- Where
- 13 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute on Aging (NIA)
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Skin Aging, Wrinkles
Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging
The purpose of this study is to determine the clinical efficacy of a combination of Astaxanthin (2 mg), Lycopene (1.8 mg), and d-alpha-Tocopherol (10 IU) in terms of its skin anti-aging properties.
- Trial name
- NCT03460860
- Testing
- Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU)
- Where
- Philippines
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- United Laboratories
Dyslipidaemia
Effect of Alpha Tocopherol and Psyllium on Lipid Levels in Dyslipidaemia Patients
The goal of this clinical trial is to find out whether Vitamin E (Alpha tocopherol), taken alone or together with Psyllium husk (a type of dietary fibre), can improve blood fat levels in adults with dyslipidaemia (abnormal blood…
- Trial name
- NCT07610304
- Testing
- Alpha tocopherol, Combination therapy (Alpha Tocopherol and Psyllium husk)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- NUR International University
Fragile X Syndrome
Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome
The Fragile X syndrome (FXS) was first described by Dr. Martin and Dr. Bell in 1943, in families with several patients affected by sex-linked mental disability.
- Trial name
- SXF-TRA152 (NCT01329770)
- Testing
- Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Yolanda de Diego Otero