Clinical trials: Als
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Amyotrophic Lateral Sclerosis
From Movement Preparation to Gait Execution in ALS
This research program will focus on gait initiation and postural control in Amyotrophic Lateral Sclerosis (ALS) patients, by comparing patients with vs without postural instability (but also in comparison to controls), by using a…
- Trial name
- GAITALS (NCT01874808)
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Amyotrophic Lateral Sclerosis
mGluR5 Imaging in ALS Using PET
In ALS models, it was shown that receptors, that bind an important messenger substance (glutamate) in the brain, are increased. In this research project, the investigators want to use a specific radioactive substance to find out…
- Trial name
- NCT05340660
- Testing
- [ 18 F]PSS232
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nathalie Braun
Amyotrophic Lateral Sclerosis
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects central and peripheral motor neurons. None of the clinical trials conducted have been clearly successful and the disease remains incurable, putting…
- Trial name
- METABOCALS (NCT03984708)
- Testing
- Samples, Indirect calorimetry, Electrical bioimpedance
- Where
- 2 sites in France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Healthy Volunteers
A Study of VRG50635 in Healthy Volunteers
The primary objectives of this study are to investigate the safety and tolerability of VRG50635 and to determine how VRG50635 is absorbed by the body.
- Trial name
- NCT06286475
- Testing
- VRG50635
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Verge Genomics
Amyotrophic Lateral Sclerosis, Neurodegenerative Disease
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular condition characterized by weakness, muscle wasting, fasciculations and increased reflexes.
- Conditions
- Amyotrophic Lateral Sclerosis, Neurodegenerative Disease, Motor Neuron Disease
- Trial name
- BCI (NCT00718458)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS
This observational study will use new smartwatch technology to continuously and remotely monitor the health of ALS patients and healthy controls over time. This information will be used to develop digital biomarkers for ALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Muscular Atrophy, Progressive, Frontotemporal Dementia
- Trial name
- NCT05830214
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis
Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, devastating, neurodegenerative disease characterized by the loss of cortical, brain stem, and spinal motor neurons.
- Trial name
- NCT03377868
- Testing
- Optic coherence tomography, Pulmonary function test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Digital Speech Markers for Monitoring ALS in Spanish Speakers
The goal of this observational study is to learn how speech and breathing change over time in Spanish-speaking individuals with amyotrophic lateral sclerosis (ALS) compared to age- and gender-matched individuals without ALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, ALS
- Trial name
- NCT07341334
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Amyotrophic Lateral Sclerosis, Parkinson Disease
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for…
- Trial name
- NCT03613038
- Testing
- Phonetic complexity effects on speech motor performance
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Ondine Syndrome, Healthy
Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)
The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.
- Conditions
- Ondine Syndrome, Healthy, Amyotrophic Lateral Sclerosis
- Trial name
- VENTIPSY (NCT03095729)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Neurodegenerative Diseases, Alzheimer Disease
Exploratory Evaluation of [11C]MPC6827
This is a phase 0 study that will enable an assessment of biodistribution and estimation of absorbed dose in humans based on data collected from five healthy volunteers, which is typically the minimum number required by the FDA…
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Amyotrophic Lateral Sclerosis
- Trial name
- NCT04575727
- Testing
- [11C]MPC6827
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Columbia University
Amyotrophic Lateral Sclerosis
Developing a Discrimination Model to Diagnose ALS
To combine several brain imaging techniques to develop a new diagnostic test to help with earlier diagnosis of amyotrophic lateral sclerosis.
- Trial name
- NCT01995903
- Testing
- MRI(magnetic resonance imaging)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Amyotrophic Lateral Sclerosis
Counterfactual Thinking in Amyotrophic Lateral Sclerosis
The properness of our past choices and action is usually judged according to what could have been if we had behaved differently.
- Trial name
- CFTSLA (NCT05768646)
- Testing
- Neuropsychological instruments
- Where
- Italy
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)
To evaluate whether dexpramipexole prolongs the QTc interval when orally administered to healthy volunteers.
- Trial name
- NCT01511029
- Testing
- Dexpramipexole, Moxifloxacin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Knopp Biosciences
Amyotrophic Lateral Sclerosis (ALS)
Safety, Tolerability, and Pharmacokinetics of FHND1002 Granules in Healthy Adults
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of FHND1002 granules in healthy adult volunteers.
- Trial name
- FHND1002-Ⅰ (NCT06782958)
- Testing
- 50mg FHND1002, 100mg FHND1002, 150 mg FHND1002
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.
Amyotrophic Lateral Sclerosis
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS cells from various types of cell cultures or lines…
- Trial name
- NCT00801333
- Where
- 2 sites in Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization