Clinical trials: Alteration of Cognitive Function
Cognitive Change
Cognitive Testing in Diverse Populations to Further the Objective and Clinical Understanding of Cognivue Study
An open-label, multi-site, validity and reliability study to obtain data on the Cognivue 5-Minute Screening and Cognivue 10-Minute Assessment tests to assess scoring and normative ranges and compare against other cognitive tests…
- Trial name
- FOCUS (NCT05712005)
- Where
- United States
- Volunteers
- 1,437 people, healthy volunteers welcome
- Sponsor
- Cognivue, Inc.
Cognitive Change, Stress, Psychological
Acute and Chronic Effects of Avena Sativa on Cognition and Stress
The flavanoid and terpene phytochemicals present in wild green oat interact with multiple mechanisms relevant to brain function; including those which would modulate cognition and stress.
- Conditions
- Cognitive Change, Stress, Psychological, Mood
- Trial name
- NCT03689348
- Testing
- Avena sativa
- Where
- United Kingdom
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Change
Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy
Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metabolism.
- Trial name
- NIR-Flow (NCT03740152)
- Testing
- Transcranial Light Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Change
Validating the Digital Virginia Tech Carilion Cognitive Examination
Currently, cognitive screening is performed in-person after the individual expresses symptoms or it is noticed by someone close to them and are largely done in clinical settings.
- Trial name
- VTC-Cog (NCT04265898)
- Testing
- The Digital Virginia Tech Carilion Cognitive Examination
- Volunteers
- healthy volunteers welcome
- Sponsor
- Carilion Clinic
Learning Disorders, Learning Disabilities
Efficacy of the MovinCog Intervention in Children
This study aims to test the efficacy of the MovinCog Intervention to enhance cognitive abilities in children 7-15 yrs. The intervention consists of two parts: a physical exercise regimen, based on high-intensity training, and a…
- Conditions
- Learning Disorders, Learning Disabilities, Cognitive Change
- Trial name
- NCT03255499
- Testing
- Exercise, Cognitive, Active control
- Where
- New Zealand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Aging, Cognitive Change
Test and Usability of Mixed-reality Screening Tool for Early Detection of Cognitive Declines
The aim of this study as part of the SCOBES-AR project is to establish and test a protocol for implementation and usability of mixed reality-enhanced multidisciplinary screening tool for early detection of cognitive impairments…
- Trial name
- SCOBES-AR (NCT05403814)
- Testing
- observational screening procedure (no intervention)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cognitive Change
Improved Cognitive Outcomes Associated With Feihe HMO With DHA/ARA in Infant Formula
The goal of this interventional clinical trial is to test the effectiveness of improving cognitive development in newly born infants fed with Feihe investigational formula product containing HMO, and DHA/ARA.
- Trial name
- NCT06146387
- Testing
- Investigational Formula, Control Formula, Breastfeeding
- Where
- 3 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Heilongjiang Feihe Dairy Co. Ltd.
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Sleep Deprivation, Military Activity
Can Ammonium Inhalants Maintain Performance in Sleep Deprived Soldiers?
This study aims to examine the effectiveness of ammonia inhalants in countering the effects of total sleep deprivation on cognitive and physical performance tests relevant to military personnel.
- Conditions
- Sleep Deprivation, Military Activity, Sleep, Cognitive Change
- Trial name
- NCT05868798
- Testing
- Ammonia Inhalant
- Where
- Czechia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jan Malecek
Cognitive Change, Nutrient Deficiency
Nutrition, Vision, and Cognition in Sport Study: Beef
The purpose of this study is to determine whether a 30 day beef intervention can improve peak cognitive performance in young, normally menstruating adult women.
- Conditions
- Cognitive Change, Nutrient Deficiency, Nutritional Anemia, Visual Spatial Processing
- Trial name
- IONSport:Beef (NCT04427852)
- Testing
- 30 day Daily consumption of 1 serving of beef, 30 day Daily consumption of 1 serving of the vegatable protein source
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cognitive Change, Mood
The Acute Effect of a Walnut Intervention on Cognitive Performance, Brain Activation, and Serum Markers of Inflammation in Young Adults
This study investigates the effect of acute walnut consumption on the cognitive behaviour, mood, brain activation, and markers of inflammation in young adults.
- Conditions
- Cognitive Change, Mood, Inflammatory Response, Brain Derived Neurotrophic Factor Level
- Trial name
- WalCog (NCT04075448)
- Testing
- Control, 50 g Walnut
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Reading
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Post-Operative Cognitive Decline in Older Adults
Study To Analyze Memory/Thinking Problems In Older Adults After Surgery
The purpose of the study is to examine specific neuroimaging predictors of memory and executive decline in older adults at various stages after total knee replacement surgery.
- Trial name
- POCD (NCT01786577)
- Testing
- Magnetic Resonance Imaging, Cognitive assessment testing
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Alteration of Cognitive Function
Physiologic Effects of Topiramate on Cognition
Data generated from this pilot project will be used to support a larger, NIH funded study to investigate the physiologic mechanisms associated with the cognitive side effects of a commonly prescribed antiepileptic drug (AED)…
- Trial name
- NCT02884050
- Testing
- Topiramate
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Impairment, Cognitive Change
Validation of a Digital Self-Administered Cognitive Screening Tool: MoCA-XpressO
The investigators conducted a validation study for the Montreal Cognitive Assessment (MoCA)-XpressO compared to the digital-MoCA test (version 8.1) as the gold standard.
- Conditions
- Cognitive Impairment, Cognitive Change, Cognitive Deficit, Assessment, Self
- Trial name
- MoCA (NCT05879562)
- Testing
- MoCA-Xpresso
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MoCA Clinic and Institute
Cognitive Change
Effect of Alpha Hope Dietary Supplement on Health and Cognitive Performance
The purpose of the present research study is to evaluate the claims about the supplement influencing cognitive function that may impact performance on cognitive task and related biochemical measures.
- Trial name
- NCT05589051
- Testing
- Drink
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Environmental Exposure, Physical Activity
Neurophysiological Mechanisms of Physical Activity Interventions in Unique Environments
This randomized intervention is designed to compare the influence of physical activity in natural and urban environments on cognitive and physical health.
- Trial name
- NCT03501953
- Testing
- Physical Activity
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northeastern University
Cognitive Change
Cognitive and Cerebral Blood Flow Effects of Zanthozylum Armatum Fruit Extract in Healthy Adults Aged 30 - 55
Zanthozylum armatum (Z. armatum)-otherwise known as Nepalese pepper, or timut-is an perennial shrub found in India and across Southeast Asia. Preparations of the bark, fruit and seeds of Z.
- Trial name
- NCT03673930
- Testing
- Zanthozylum armatum
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northumbria University