Clinical trials: Altered State of Consciousness
COVID-19 Pandemic
The Combined Usage of Clinical Physical Finding in Management of COVID 19 Patients
Physiological indicators such as blood pressure, heart rate, respiratory rate, and consciousness status of COVID-19 patients are used to apply the START (simple triage and rapid treatment, START), Modified Early Warning Score…
- Trial name
- NCT06528119
- Testing
- COVID 19 pandemic
- Where
- Taiwan
- Volunteers
- 10,000 people
- Sponsor
- St. Martin De Porress Hospital
Neurologic Disorder, Brain Injuries
Effect of Transcranial Direct Current Stimulation in Altered States of Consciousness
Transcranial Direct Current Stimulation (tDCS) is a non-invasive, painless brain stimulation treatment that uses low-intensity direct electrical currents to stimulate specific parts of the brain.
- Trial name
- tDCS-GCA (NCT06236503)
- Testing
- Real Stimulation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Healthy
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
The primary objective of this study is to determine whether equivalent moderately high doses of LSD, psilocybin, and DMT produce qualitatively similar peak effects when the effect duration is standardized with ketanserin.
- Trial name
- LPD (NCT06899334)
- Testing
- LSD, Psilocybin, DMT
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Neuronal Correlates of Altered States of Consciousness
The aim of the present study is to assess the neuronal correlates of alterations in waking consciousness pharmacologically induced by a 5-hydroxytryptamine (HT)2A receptor agonist in healthy subjects using functional magnetic…
- Trial name
- 5HT2A-fMRI (NCT02308969)
- Testing
- LSD
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Psychedelic Effects in Healthy Volunteers
Psilocybin Administration With 5-HT1a Blockade
The purpose of this study is to assess the effects of 5-HT1A receptor blockade on the acute subjective effects of psilocybin, as measured through subjective survey measures and acute electroencephalography (EEG).
- Trial name
- PsilBlock1 (NCT07565493)
- Testing
- Pindolol, Psilocybin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin
LSD (lysergic acid diethylamide) and psilocybin (the active substance in "magic mushrooms") are widely used for recreational purposes.
- Trial name
- LSD-psilo (NCT03604744)
- Testing
- LSD, Psilocybin
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Bodily Self-Consciousness, Interoception
Hyperventilation Effects on Bodily Self-Consciousness
This study examines how voluntary fast, deep breathing (hyperventilation) affects the way healthy adults perceive their own body.
- Conditions
- Bodily Self-Consciousness, Interoception, Healthy Volunteers
- Trial name
- HYPERSELF (NCT07769710)
- Testing
- Voluntary hyperventilation (guided paced breathing), Normal spontaneous breathing (within-subject control), Synchronous respiratory-visual VR feedback
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Altered State of Consciousness, General Anesthetics
Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
This prospective observational study is designed to investigate and compare the dynamic features of whole-brain electroencephalogram (EEG) during the induction of unconsciousness using various anesthetic agents with distinct…
- Trial name
- NCT07410702
- Testing
- Anesthetic Agents
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Huazhong University of Science and Technology
Healthy
Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study)
Serotonin receptors, especially the 5HT2A receptor, are thought to be involved in the effects of various recreationally used psychedelic substances such as LSD.
- Trial name
- LDR (NCT03321136)
- Testing
- LSD
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness
Mescaline (the active substance in Peyote and San Pedro cacti) is a classic and long known serotonergic psychedelic substance (hallucinogen) that is widely used for recreational, spiritual, and/or ethno medical purposes.
- Trial name
- MDR (NCT04849013)
- Testing
- Mescaline 100mg, Mescaline 200mg, Mescaline 400mg
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Disorder of Consciousness, MMN
Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients
In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as…
- Conditions
- Disorder of Consciousness, MMN, Modification of Cognitive Status Indication, Anoxic Brain Damage
- Trial name
- VEG-TDCS (NCT04614792)
- Testing
- Transcranial direct current stimulation
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Oded Meiron
Healthy Volunteers
Neural Correlates of Self
Despite the increasing popularity of mindfulness meditation and hypnosis in healthcare and in the general community the underlying neurobiological mechanisms are unclear.
- Trial name
- NeuCoSe (NCT03206840)
- Testing
- "control", "meditation", "hypnosis".
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Altered States of Consciousness, Wellbeing
Comparing Effects of Intense Breathwork to Meditation on Altered States of Consciousness
This study aims to investigate the impact of high ventilation breathwork (HVB) and meditation on altered states of consciousness (ASCs).
- Trial name
- A2A (NCT06916312)
- Testing
- High ventilation breathwork, Meditation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Social Anxiety
Breathe Hard to Breathe Easy: Online Breathwork-Assisted Therapy for Social Anxiety
This study aims to investigate the potential of supplementing psychotherapy with breathing techniques as a new online therapeutic approach to reduce social anxiety (SA).
- Trial name
- BHBE (NCT07259005)
- Testing
- Breathwork-Assisted Therapy 1, Breathwork-Assisted Therapy 2
- Where
- Netherlands
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Addiction, Substance Abuse
Breathwork-assisted Treatment for Cannabis Use Disorder
The purpose of this proof-of-concept study is to evaluate the safety, feasibility and acceptability of a breathwork workshop intervention in individuals with cannabis use disorder.
- Conditions
- Addiction, Substance Abuse, Cannabis Use Disorder, Cannabis Use
- Trial name
- NCT05219825
- Testing
- Breathwork workshop
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Elias Dakwar
Psilocybin, Music Intervention
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
The goal of this clinical trial is to understand how personally meaningful, autobiographically salient music compares to standardized playlists when combined with psilocybin in healthy adults ages 21 to 75.
- Trial name
- PRoMiSS (NCT07180108)
- Testing
- Psilocybin (high dose), Playlist 1, Playlist 2
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness
Psilocybin (active compound of "magic mushrooms") is a prototypical psychedelic substance that acts via agonism on serotonin (5-HT) 2A receptors. Psilocybin is rapidly metabolized into its active metabolite psilocin.
- Trial name
- PDR (NCT06796361)
- Testing
- Ketanserin 40mg plus Psilocybin 40mg, 40mg Psilocybin, 20mg Psilocybin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Altered Waking States of Consciousness in Healthy Humans
Characterization of Altered Waking States of Consciousness in Healthy Humans
Altered waking states of consciousness and its underlying functional organization have gained increasing interest in recent years, i.e. in identifying the neural basis of consciousness.
- Trial name
- NCT03853577
- Testing
- TMS/EEG
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Zurich