Clinical trials: Altitude
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude, Six-minute Walk Test
Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of descent from high altitude (Quito Ecuador: 2850m) to sea level on six-minute walking distance and scores in healthy individuals, who live permanently >2600m.
- Conditions
- High Altitude, Six-minute Walk Test, High Altitude Effects, Healthy
- Trial name
- NCT07801872
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Hypoxia, Exogenous Ketosis
The Effects of Ketone Ester Supplementation During a 5 Week Live High, Train Low Altitude Training Camp
This study aims to investigate the effects of post-exercise and pre-sleep exogenous ketosis via oral ketone ester supplementation during a 5 week simulated altitude training camp.
- Trial name
- NCT06596083
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Altitude Hypoxia
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on sleep disordered breathing in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536507
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypoxia
Ketone Esters for Optimization of Operator Performance in Hypoxia
The primary purpose of the study was to investigate effects of an orally administered ketone ester drink on endurance exercise performance during acute extreme hypoxia.
- Trial name
- HVMN7 (NCT07065864)
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Iron Deficiency Anemia, Iron Deficiency (Without Anemia)
Effect of Altitude on Iron Absorption in Iron Depleted Women
One of the most common nutritional deficiencies worldwide is iron deficiency. Iron deficiency is considered the main cause of anaemia in developing countries, including those in South America.
- Conditions
- Iron Deficiency Anemia, Iron Deficiency (Without Anemia), Altitude Hypoxia
- Trial name
- PotatoAlt (NCT05500014)
- Testing
- Biofortified potato, not genetically modified
- Where
- 2 sites in Peru
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Distance University of Applied Sciences
Pulmonary Disease, Cardiovascular Disease
Cardio-Respiratory Health and Indoor Pollution
The aim of this study is to assess in the sample of population resident in the KHUMBU valley (NEPAL): 1. the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute…
- Trial name
- NCT01329159
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
Altitude, Ultraviolet Rays
Ultraviolet Exposure, Antioxidant Use and Skin Erythema at Extreme High Altitude
With the increasing tourism and adventure travel into extreme environments comes the need to reassess the required protection against ultraviolet (UV) radiation and possible other oxidative stresses.
- Conditions
- Altitude, Ultraviolet Rays, Antioxidants, Oxidative Stress
- Trial name
- NCT00685438
- Where
- Nepal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Hypoxemia, Acute Mountain Sickness (AMS)
The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude
High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood…
- Conditions
- Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
- Trial name
- NCT07517068
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Severe High Altitude Pulmonary Edema, Severe High Altitude Cerebral Edema
Key Diagnostic & Therapeutic Technologies for Severe Acute High Altitude Disease (SAHAD): Integration and Application
This study aims to establish a key technical system for the diagnosis and treatment of severe acute mountain sickness based on real-world clinical data in Xizang, develop standardized diagnosis and treatment protocols and an…
- Trial name
- SAHAD (NCT07639931)
- Testing
- Multicenter study of HAPE：CPAP or BiPAP Group, Multicenter study of HAPE group：NO Group, Protocol for Proteomics and Peptidomics Study of HAPE：Case Group
- Where
- China
- Volunteers
- 3,035 people, healthy volunteers welcome
- Sponsor
- Tibet Autonomous Region People's Hospital
Hypoxia, Exercise Performance
Acetazolamide and Exercise Performance at Altitude
The goals of the present study are to evaluate whether the most common, and effective, treatment for acute mountain sickness (AMS), acetazolamide (AZ), has a negative, positive, or no influence on exercise performance, cognitive…
- Conditions
- Hypoxia, Exercise Performance, Cognitive Function, Dexterity
- Trial name
- NCT03525561
- Testing
- Acetazolamide Pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Acute Mountain Sickness and Fatigue
A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude
Acute exposure of the unacclimatized human body to high altitude leads to health complications, such as loss of exercise performance capacity and fatigue.
- Trial name
- GQ02 (NCT01794078)
- Testing
- Aminophylline 400 mg, Ambrisentan 5 mg
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Robert J Noveck, M.D.
Negative Air Ions, Altitude Sickness
The Effects of Artificial Air Negative Ions on High-Altitude Acclimatization, Serum HIF1, and PWC170 Index
To explore the effects of negative ions generated by an ion converter on the high-altitude acclimatization of healthy populations and their impact on serum HIF1 (hypoxia-inducible factor 1) and PWC170 index after entering…
- Conditions
- Negative Air Ions, Altitude Sickness, High-altitude Adaptation
- Trial name
- 2022JW (NCT07056751)
- Testing
- Air negative ion intervention study, No air negative ion intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Putian City, Putian, Fujian
Hypoxia, Endotoxemia
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
The objective of the present protocol is to study whether a low level of oxygen in the blood will affect the immune response to as well as cerebral blood flow and metabolism during an infection and, conversely, whether the acute…
- Conditions
- Hypoxia, Endotoxemia, Healthy
- Trial name
- NCT00332267
- Testing
- Endotoxin infusion, Normobaric hypoxia
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neonatal Disease, Altitude Hypoxia
Reference Interval for SPO2 in Neonates at High Altitudes During First 2 Hours and Umbilical Artery Blood Gas
Pulse oximetry offers real time and non-invasive estimation of arterial oxygen saturation in a cost-effective way, and has become a critical tool in guiding the usage of supplemental oxygen in sick newborns.
- Trial name
- NCT05468515
- Testing
- pulse oxygen saturation
- Where
- China
- Volunteers
- 956 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Arrhythmias, Cardiac, Tachycardia, Ventricular
Cardiac Arrhythmias at Extreme Altitude
Background: Exposure to high altitudes has been associated with an increased risk of cardiac arrhythmias in healthy subjects and an increased risk of sudden cardiac death.
- Conditions
- Arrhythmias, Cardiac, Tachycardia, Ventricular, Tachycardia, Supraventricular, Bradycardia
- Trial name
- SUMMIT (NCT05676398)
- Testing
- Ambulatory rhythm recording
- Where
- Nepal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern