Clinical trials: Altitude
Sleep-Disordered Breathing, Glucose Intolerance
Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing
Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance.
- Trial name
- NCT05462834
- Testing
- Compressed Air, Supplemental Oxygen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Acute Mountain Sickness
Inhaled Budesonide and Acute Mountain Sickness
The primary objective of the study is to investigate the effect of inhaled budesonide on the incidence of AMS. The primary study question to ask is: 1.
- Trial name
- NCT02811016
- Testing
- Budesonide 200, Budesonide 800
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Health, Children, Only
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora.
- Conditions
- Health, Children, Only, Gut Microbiota
- Trial name
- NCT06157346
- Where
- China
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Acute Mountain Sickness
Alternative Treatments in Acute Mountain Sickness
The purpose of this research is to support a hypothesis that osteopathic manual medicine (OMM) and / or a 10 cmH2O end-expiratory pressure (PEEP) could be used in the prevention of acute mountain sickness (AMS).
- Trial name
- TAIA (NCT03956472)
- Testing
- Osteopathic protocol for improving drainage of LCS, PEEP 10cmH2O, Fake Osteopathic protocol
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Acute Mountain Sickness
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness
Acute mountain sickness (AMS) is a common condition that can occur when healthy people travel quickly to high altitude. Typical symptoms include headache, nausea, tiredness, dizziness, and poor sleep.
- Trial name
- NCT07653516
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Acute Mountain Sickness
Colorado-Oregon Altitude Study
Investigating the utility of prophylactic treatment with iron sucrose and/or erythropoietin on the prevention of acute mountain sickness in fit, young, healthy individuals.
- Trial name
- COAST (NCT05734716)
- Testing
- Erythropoietin, Iron sucrose (Venofer), Sterile Sodium Chloride
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Hypoxia, Altitude, Blood Flow Restriction
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions.
- Conditions
- Hypoxia, Altitude, Blood Flow Restriction, Resistance Training
- Trial name
- NCT06171841
- Testing
- low-intensity resistance training, high-intensity resistance training, low-intensity resistance training combined with blood flow restriction
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Neurocognition
Effect of Supplemental Oxygen Therapy on Neurocognitive Performance in Healthy Highlanders
Exposure to high altitudes, defined as locations above 2500 m, has been shown to cause cognitive alternations due to reduced blood oxygenation (SpO2).
- Trial name
- SPIRIT_1 (NCT07651917)
- Testing
- Supplemental oxygen therapy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of theophylline and bambuterol in healthy human…
- Trial name
- NCT01566565
- Testing
- Theophylline and Bambuterol
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Norwegian Armed Forces Medical Service
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Cerebral Edema
Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)
When the brain detects a drop in oxygen levels in the blood (hypoxia) there is a compensatory increase in blood flow. Acute mountain sickness (AMS) is a cluster of symptoms which commonly occur in those ascending to high altitude…
- Trial name
- D4H (NCT03341676)
- Testing
- Dexamethasone
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Hypobaric Hypoxia, Hypobaric Normoxia
Cognition at Altitude in HEMS - Part II
The aim of the current study is to evaluate under blinded conditions, both in a simulated environment and during helicopter flight, the effect of a rapid (within 20 minutes) exposure to altitude (4000 m asl) on physiological…
- Conditions
- Hypobaric Hypoxia, Hypobaric Normoxia, Cognitive Performance, Emergency Medicine
- Trial name
- HEMS II (NCT05073406)
- Testing
- Altitude exposure in hypobaric normoxic condition, Altitude exposure in hypobaric hypoxic condition
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Altitude Intolerance, High-Altitude Illness
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex.
- Trial name
- NCT00202683
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Société Française de Cardiologie
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
- Trial name
- NCT02829255
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
Erythropoietin in the Prevention of Acute Mountain Sickness
Acute mountain sickness (AMS) is a syndrome of nonspecific symptoms and is therefore subjective. The Lake Louise Consensus Group defined acute mountain sickness as the presence of headache in an unacclimatized person who has…
- Trial name
- EPO-AMS (NCT01665781)
- Testing
- Erythropoietin
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Ulsan
Acute Mountain Sickness, High Altitude Pulmonary Edema
Hemodynamic Changes in Altitude Adaptation
We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of…
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT01698619
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Goethe University
High Altitude Headache
Intracranial Pressure in Experimental Models of Headache
The purpose of this study is to determine whether increased pressure in the head is elevated in people who suffer from High Altitude Headache.
- Trial name
- NCT01288781
- Testing
- Acetazolamide, Lactose monohydrate
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Hypoxia, Altitude, Cold Exposure
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the…
- Conditions
- Hypoxia, Altitude, Cold Exposure, Heat Exposure
- Trial name
- NCT06159374
- Testing
- exercise and environmental conditions
- Where
- Poland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland