Clinical trials: Altitude
Weight Loss, Other Effects of High Altitude
Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization
This research will evaluate nutrition requirements for missions at high altitude (i.e. >7800 feet above sea level) and the information obtained can be used to optimize nutrient content specifications for combat rations.
- Trial name
- NCT02731066
- Testing
- Standard pro, High pro, carbo bev
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
Acute Mountain Sickness (AMS)
Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness
This trial is aimed to evaluate the effects of "Wu Zhu Yu Tang" on the prevention of Acute Mountain Sickness(AMS).
- Trial name
- NCT01682551
- Testing
- Chinese Medicine, Acetalozamide
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Mountain Sickness, Chronic
Chronic Mountain Sickness, Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD) or emphysema, represent major medical and socio-economical problems and one of the leading cause of morbidity and mortality in the…
- Trial name
- CMS (NCT01182792)
- Testing
- Vitamin C and E
- Where
- 2 sites in Bolivia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
High-altitude Training Adaptations in Adolescent Male Rowers
Effects of a 4-Week Altitude Training on Sport-Specific Performance, Body Composition, and Cardiac and Pulmonary Function in Adolescent Male Rowers
This study aims to investigate the effects of a 4-week altitude training program on adolescent male rowers. The research will examine changes in athletic performance, athletic body composition, athletic cardiac function, athletic…
- Trial name
- NCT07612956
- Testing
- 4-Week Altitude Training
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Hypothermia, Hypoxia
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
Warfighter Performance Optimization in Extreme Environments remains an area of important and intense investigation, with the following goals: (1) Optimize, sustain and augment medical readiness and physiological/ psychological…
- Conditions
- Hypothermia, Hypoxia, Mountain Sickness
- Trial name
- PhITHy-Ho (NCT06129825)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
High Altitude, Healthy Adult
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently >2600m.
- Conditions
- High Altitude, Healthy Adult, Echocardiography, Pulmonary Resistance
- Trial name
- NCT07804485
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Adults, High Altitude
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Human milk oligosaccharides (HMOs) are the third-most abundant component in mothers' milk and are an important prebiotic factor for the development of the gut microbiota of infants, promoting the growth of certain beneficial…
- Conditions
- Healthy Adults, High Altitude, Isolation, Social
- Trial name
- NCT06133530
- Testing
- Human milk oligosaccharides, Maltose
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IU University of Applied Sciences
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction at Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00724321
- Testing
- iloprost
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Hypoxia
High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia
The aim of the project "High Altitude Medical Research Expedition Himlung 2013" (HiReach2013) is to comprehensively investigate the cerebral, cardiovascular and pulmonary adaptation and the reactions of the human immune system…
- Trial name
- HiReach 2013 (NCT01953198)
- Testing
- Hypobaric hypoxia
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypoxia, Altitude Sickness
Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely
This project will consist of two studies, each investigating resting and exercise cardio-respiratory responses during exposure to hypoxia in individuals born prematurely and individuals born at full term of two different age…
- Conditions
- Hypoxia, Altitude Sickness, Tolerance
- Trial name
- PreTerm (NCT02780908)
- Testing
- Graded exercise testing, Resting testing
- Where
- 2 sites in Slovenia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Acute Mountain Sickness and Fatigue
A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude
Acute exposure of the unacclimatized human body to high altitude leads to health complications, such as loss of exercise performance capacity and fatigue.
- Trial name
- GQ02 (NCT01794078)
- Testing
- Aminophylline 400 mg, Ambrisentan 5 mg
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Robert J Noveck, M.D.
Neonatal Disease, Altitude Hypoxia
Reference Interval for SPO2 in Neonates at High Altitudes During First 2 Hours and Umbilical Artery Blood Gas
Pulse oximetry offers real time and non-invasive estimation of arterial oxygen saturation in a cost-effective way, and has become a critical tool in guiding the usage of supplemental oxygen in sick newborns.
- Trial name
- NCT05468515
- Testing
- pulse oxygen saturation
- Where
- China
- Volunteers
- 956 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Hypoxia
Dark Chocolate and Exercise Performance in Hypoxia
Nitrate supplements (beetroot juice, pure sodium nitrate) have become common among endurance athletes because the ingestion of exogenous nitrate leads to increased levels of nitric oxide (NO) in the body.
- Trial name
- NCT03945916
- Testing
- Dark chocolate
- Where
- 2 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Physiological Function in Low Oxygen Environment
Rapid Acclimatization to Hypoxia at Altitude
In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower…
- Trial name
- NCT01702025
- Testing
- Aminophylline, Methazolamide, Aminophylline+Methazolamide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Decompression Sickness, Acute Mountain Sickness
Decompression Tables for Diving at Altitude
The aims of this proposal are to test current USN procedures for adjusting decompression procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression algorithm for no-stop dives to 100 feet of sea…
- Trial name
- NCT03390335
- Testing
- Pressure, Breathing Gas
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Duke University