Clinical trials: Altitude
Hypoxia-Induced Pulmonary Artery Hypertension
Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of the factors implicated in high-altitude pulmonary oedema.
- Trial name
- NCT00260819
- Testing
- Bosentan, Bosentam TRACLEER
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Altitude, Healthy
Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in healthy individuals, who live…
- Conditions
- High Altitude, Healthy, Healthy Adult, Six-minute Walk Test
- Trial name
- NCT07797088
- Testing
- Re-Ascent sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Acute Mountain Sickness, Subclinical High Altitude Pulmonary Edema
The Incidence of Subclinical High-altitude Pulmonary Oedema at High Altitude
The aim of this investigation is to determine the incidence of silent interstitial pulmonary edema by chest ultrasound at moderate altitude (3905m).
- Trial name
- NCT01794130
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Pre-Eclampsia
Are There Sleep-related Factors That Contribute to an Increased Incidence of Pre-eclampsia at Altitude?
Women at altitude have an increased incidence of pre-eclampsia. Populations at altitude have a greater incidence of sleep apnea. And women with sleep apnea are at increased risk of developing preeclampsia.
- Trial name
- NCT06702475
- Testing
- Home Sleep Test with Watch PAT-one
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypoxia, Altitude Hypoxia
The Psychophysiological Effect of Simulated and Terrestrial Altitude
The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.
- Conditions
- Hypoxia, Altitude Hypoxia, Altitude Sickness, Altitude
- Trial name
- Hypoxia (NCT04075565)
- Testing
- Terrestrial altitude, Cloud 9
- Where
- 3 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Acute Mountain Sickness
Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness
Acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) are complications of rapid ascent to high altitude.
- Trial name
- NCT00664001
- Testing
- Anti-oxidant supplementation
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Altitude Physiology Expeditions
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Altitude Hypoxia, Ventilation
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Conditions
- Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress
- Trial name
- NCT03368352
- Testing
- Melatonin, Hypoxia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Altitude, Pulmonary Hypertension
Effect of Bosentan on Exercise Capacity at High Altitude
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
- Trial name
- NCT00432978
- Testing
- Bosentan administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
High Altitude, Healthy
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy…
- Conditions
- High Altitude, Healthy, Healthy Adult, High Altitude Effects
- Trial name
- NCT07804589
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Acute Mountain Sickness
Drug Combination on Exercise Performance at High Altitude
This study is being conducted to determine the effectiveness of using two FDA approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at…
- Trial name
- NCT01902758
- Testing
- ambrisentan and theophylline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Montana
Altitude Hypoxia
Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on maximal exercise performance in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536455
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude
Establishing the Reference Interval for Pulse Oxygen Saturation in Neonates at High Altitude
The now widely used reference interval for pulse oxygen saturation of the neonate after 24 hours of birth has been developed relying on data from low altitude.It is not suitable for neonates at high altitude.
- Trial name
- NCT05115721
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
AMS, Acute Mountain Sickness
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI…
- Trial name
- PAMS (NCT06310642)
- Testing
- Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Adult
Effects of RIC on Cognitive Function and Blood Oxygen Levels in Unacclimatized Adult at High Altitude
Several studies have shown cognitive impairment such as memory, perception and learning skill during ascent to high altitudes. However, few studies have directly investigated the effect of high altitudes exposure on attention-a…
- Trial name
- NCT03728114
- Testing
- RIC
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Athletic Performance, Physical Endurance
Event-Specific Adaptations to CrossFit and Running-Based HIIT in Elite Distance Runners at Moderate Altitude
The goal of this clinical trial is to compare the effects of two high-intensity training programs on physical performance and physiological adaptations in elite male middle- and long-distance runners aged 25 to 35 years who live…
- Conditions
- Athletic Performance, Physical Endurance, Altitude Training Adaptation, Aerobic Capacity
- Trial name
- NCT07675577
- Testing
- Running-Based High-Intensity Interval Training (HIIT), CrossFit-Based High-Intensity Training (CF)
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Altitude Training, Race Walking
Effects of Alternating Altitude Training Versus Fixed-Altitude Training on Exercise Capacity and Physiological Adaptations in Elite Race Walkers: A Randomized Controlled Trial
This randomized controlled trial aims to compare the effects of alternating altitude training and fixed-altitude training on physical performance and physiological adaptations in elite race walkers living at altitude.
- Trial name
- NCT07718009
- Testing
- Alternating Altitude Training, Fixed-Altitude Training
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
High Altitude
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude
Ibuprofen is often taken by travelers to high altitude to treat the symptoms of acute mountain sickness such as headache and malaise.
- Trial name
- NCT02233582
- Testing
- Ibuprofen, Sugar pill
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00708565
- Testing
- iloprost
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System