Clinical trials: Altitude Effectiveness
Acute Mountain Sickness (AMS)
Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
The specific aim of this double blind, randomized phase III trial is to evaluate the safety and efficacy of T89 in preventing Acute Mountain Sickness (AMS) and relieving the symptoms of AMS after rapid ascent.
- Trial name
- NCT04993729
- Testing
- T89 capsule
- Where
- 3 sites in United States, China
- Volunteers
- 853 people, healthy volunteers welcome
- Sponsor
- Tasly Pharmaceuticals, Inc.
Hypertension, Pulmonary, Altitude Sickness
Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
During ascent to high altitude there is a physiologic response to hypoxia that results in an elevated pulmonary arterial pressure associated with decreased exercise performance, altitude-induced pulmonary hypertension, and high…
- Trial name
- NCT02024386
- Testing
- Riociguat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Richard Moon
Acute Mountain Sickness
EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
The aim of this randomized, controlled trial is to evaluate the safety and efficacy of Suxiao Jiuxin Pills for prevention of acute mountain sickness (AMS) after high altitude exposure in healthy volunteers, and its influences on…
- Trial name
- EVEREST (NCT06531161)
- Testing
- Suxiao Jiuxin Pill
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Acute Mountain Sickness
Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy
This double blind randomized trial will compare ibuprofen to acetazolamide for the prevention of acute mountain sickness. These drugs have never been directly compared for efficacy.
- Trial name
- ASPIRATE (NCT03154645)
- Testing
- Ibuprofen, Acetazolamide
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Grant S Lipman
Altitude Effectiveness
Altitude Training Effectiveness; Is There a Role for Sleep and Menstrual Health?
Therefore, the present study aims to evaluate the role of the impact of altitude on sleep and the menstrual cycle in the inter- and intraindividual variability of altitude training effectiveness.
- Trial name
- FEMHEALTH (NCT07337928)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Performance, Executive Function (Cognition)
Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia
This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for ~180 minutes).
- Conditions
- Cognitive Performance, Executive Function (Cognition), Working Memory, Hypoxia Induced Cognitive Impairment
- Trial name
- NCT07166835
- Testing
- Nootropics (ginkgo biloba, nicergoline, piracetam, or others)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
AMS, Acute Mountain Sickness
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI…
- Trial name
- PAMS (NCT06310642)
- Testing
- Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Acute Mountain Sickness
Altitude Sickness Prevention and Efficacy of Comparative Treatments
This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude.
- Trial name
- ASPECT (NCT02604173)
- Testing
- Budesonide, Acetazolamide
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Mountain Sickness (AMS)
Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
Acute mountain sickness (AMS) is one of three syndromes of altitude illness. It is very common when people venture over 2500 meters altitude.
- Trial name
- NCT03552263
- Testing
- T89 capsule
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tasly Pharmaceuticals, Inc.