Clinical trials: Alveolar Hypoventilation
Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea
Simplus and Eson Non-Invasive Ventilation (NIV) Evaluation - Germany
This investigation is designed to evaluate the performance, comfort and ease of use of the Simplus and Eson masks amongst NIV patients who are currently on Bi-level therapy
- Conditions
- Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
- Trial name
- NCT02726048
- Testing
- Simplus/Eson
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Fisher and Paykel Healthcare
Obesity Hypoventilation Syndrome
Prevalence of Obesity Hypoventilation Syndrome
Rationale of the "BIO-OHS" study (Prevalence of Obesity Hypoventilation Syndrome): The overall prevalence of Obesity Hypoventilation Syndrome (OHS) has never been directly assessed in the general population.
- Trial name
- BIO-OHS (NCT01903135)
- Testing
- Blood test analysis in the clinical labs, Pneumologist consult to establish the diagnosis of OHS
- Where
- 5 sites in France
- Volunteers
- 1,004 people
- Sponsor
- AGIR à Dom
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS)
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Diseases (NMD)
- Trial name
- Vivo NOVA (NCT06560411)
- Testing
- Non-Invasive Ventilation
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Breas Medical, Inc.
ROHHAD, Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation
International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation (ROHHAD) Registry
The Center for Autonomic Medicine in Pediatrics (CAMP) has collaborated with doctors from around the world to build the first International ROHHAD (Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic…
- Trial name
- NCT03135730
- Testing
- ROHHAD
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Nasal High Flow Therapy, Intensive Care Unit
High Flow Therapy in ICUs Across Ibero America
The study aims to describe the use of Nasal High Flow (NHF) in the intensive care units of participating centers in Iberoamerica.
- Conditions
- Nasal High Flow Therapy, Intensive Care Unit, Ventilatory Failure, Hypoxia
- Trial name
- T-Calfi (NCT03364946)
- Testing
- No intervention
- Where
- 9 sites in Colombia, Dominican Republic and 2 more
- Volunteers
- 255 people
- Sponsor
- Fundación Santa Fe de Bogota
Acute Exacerbation of COPD, Acute Exacerbation of Bronchiectasis
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in…
- Conditions
- Acute Exacerbation of COPD, Acute Exacerbation of Bronchiectasis, Acute Exacerbation of Asthma, Interstitial Lung Disease
- Trial name
- DVD (NCT04098094)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Overweight and Obesity, Overweight or Obesity
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding obesity.
- Conditions
- Overweight and Obesity, Overweight or Obesity, Obesity, Obesity, Morbid
- Trial name
- NCT04100616
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Neuromuscular Disorders, Chest Wall Disorders
Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern
The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.
- Conditions
- Neuromuscular Disorders, Chest Wall Disorders, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- NCT01991535
- Testing
- Spontaneous Ventilation Mode, Controlled Ventilation Mode, Simulator Ventilation Mode
- Where
- Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Obesity Hypoventilation Syndrome
Alternative of Treatment in Obesity Hypoventilation Syndrome
Primary objectives: evaluate the efficacy of noninvasive ventilation (NIV) treatment versus continuous positive airway pressure (CPAP) and life style modification treatment in Obesity Hypoventilation Syndrome (OHS), with PCO2…
- Trial name
- NCT01405976
- Testing
- life style modification, noninvasive ventilation, CPAP
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Medical Complication
Postoperative Opioid and Respiratory Depression in Opioid Naive and Chronic Opioid Patients
Aim: To describe the duration of desaturation and bradypnea in postoperative opioid-naïve and chronic opioid patients. Patients: 691 patients included from two previous WARD (Wireless Assessment of Respiratory and circulatory…
- Trial name
- NCT06227208
- Testing
- Continuous vital sign monitoring
- Where
- 2 sites in Denmark
- Volunteers
- 691 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS)
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU)…
- Trial name
- NCT06983418
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Mansoura University
Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease
Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients
The goal of this clinical trial is to clinically validate a system for the monitoring of patients' respiratory function and automated oxygen treatment proposal using non-invasive ventilation devices in the treatment of intensive…
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease, Interstitial Lung Disease, Pneumonia
- Trial name
- Smartassistant (NCT06090149)
- Testing
- PHASE 1 Lowenstein medical BiLevel Prisma 25ST device: withount oxygen support., PHASE 2. Continous/Bilevel positive airway presure with additional oxygen support by Devilbiss 525 KS oxygen concentrator
- Where
- Latvia
- Volunteers
- 30 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Gastrostomy, Ventilatory Failure
Concomitant Bedside Percutaneous Tracheostomy and Ultrasound Gastrostomy
The goal of this research study is to assess the FDA approved technique for inserting a feeding tube (gastrostomy) along with a breathing tube (tracheostomy) for patients that cannot breathe or eat on their own in the ICU…
- Conditions
- Gastrostomy, Ventilatory Failure, Respiratory Failure
- Trial name
- TPUG (NCT05955534)
- Testing
- TPUG, PEG, PRG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Ventilatory Failure
Comparison of Two Different NCPAP Methods in Preterm Infants With Respiratory Distress Syndrome
is to compare introduction of two different NCPAP methods in terms of mechanical ventilation (MV) need (non-invasive respiratory support failure) and surfactant need within the first 72 hours of life in preterm infants with…
- Trial name
- (NCPAP) (NCT03400670)
- Testing
- ventilator NCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD)
The investigators hypothesize that continuation of non-invasive ventilation (NIV) at home after an episode of acute hypercapnic respiratory failure (AHRF) treated by NIV in COPD patients would reduce the likelihood of death and…
- Trial name
- NCT00429156
- Testing
- Home non-invasive ventilation
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- United Christian Hospital
Chronic Obstructive Pulmonary Disease
Innovation in NOn Invasive Ventilation in COPD Patients Treated by Long Term Oxygen Therapy
The aim of this study is to investigate the efficacy of non-invasive ventilation (NIV) on nocturnal hypoventilation in patients with chronic obstructive pulmonary disease (COPD) who are on long term oxygen therapy (LTOT) at home.
- Trial name
- INOV-LTOT (NCT03584269)
- Testing
- NIV Device + LTOT, LTOT
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
Assessment of Breathing Pattern During NIV
COPD and OHS are respiratory conditions that disrupt normal breathing. Positive airway pressure, specifically Non-Invasive Ventilation (NIV), has been shown to improve breathing and reduce symptoms in patients with these…
- Trial name
- NCT06682286
- Testing
- NIV mask A, NIV mask B
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
Slow Breathing, Acute Myocardial Infarction
The Effect of Slow Breathing Exercise Applied to Patients on Pulse, Blood Pressure and Quality of Life
This study was designed as a randomized controlled experimental type in order to determine the effect of slow breathing exercise applied after the procedure on heart rate, blood pressure and quality of life in patients who…
- Trial name
- NCT06098222
- Testing
- Slow breathing exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Sleep Apnea, Obstructive, Obesity Hypoventilation Syndrome
Feasibility of a Modified Positive Airway Pressure Device to Treat Sleep Disordered Breathing
This study will use a modified version of a positive airway pressure device to supply air to the participant, while undergoing supervised polysomnography.
- Trial name
- NCT02368639
- Testing
- Fisher & Paykel Healthcare PAP Device
- Where
- New Zealand
- Volunteers
- 14 people
- Sponsor
- Fisher and Paykel Healthcare