Clinical trials: Alveolar Lung Disease
COVID-19
Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)
Phase IV study to evaluate the effectiveness of additional inhaled sargramostim (GM-CSF) versus standard of care on blood oxygenation in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure.
- Trial name
- SARPAC (NCT04326920)
- Testing
- Sargramostim, Control
- Where
- 4 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- University Hospital, Ghent
Lung Cancer
Gene Therapy in Treating Patients With Non-small Cell Lung Cancer That Cannot Be Surgically Removed
RATIONALE: Exposing tumor cells to the p53 gene may improve the body's ability to fight non-small cell lung cancer. PURPOSE: Phase I trial to study the effectiveness of gene therapy in treating patients who have non-small cell…
- Trial name
- NCT00003649
- Testing
- Ad5CMV-p53 gene
- Where
- 3 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Atelectasis, Mechanical Ventilation
Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography
During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis…
- Conditions
- Atelectasis, Mechanical Ventilation, General Anesthesia, Prone Position
- Trial name
- NCT07325812
- Testing
- Alveolar Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Acute Respiratory Distress Syndrome (ARDS), Hypovolemia
Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)
The need for fluid resuscitation (FR) in ICU patients with acute respiratory distress syndrome (ARDS) is common. Indeed, relative or absolute hypovolemia is a common phenomenon that the intensivist must recognize early and treat…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypovolemia, Pulmonary Edema
- Trial name
- IROCA (NCT01763853)
- Testing
- 4% albumin
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lung Cancer
Topotecan and Vinorelbine in Treating Patients With Recurrent Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as topotecan and vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00287963
- Testing
- topotecan hydrochloride, vinorelbine tartrate
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical University of South Carolina
Lung Cancer, Metastatic Cancer
Paclitaxel and Hyperthermic Perfusion in Treating Patients With Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Heating paclitaxel to several degrees above body temperature and infusing it to the affected area around the…
- Trial name
- NCT00020007
- Testing
- isolated perfusion, paclitaxel, hyperthermia treatment
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Extrinsic Allergic Alveolitis
Bronchoalveolar Immune Response Determination
The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens.
- Trial name
- BIRD (NCT01237145)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Bossink, A.W.J.
COPD
Functional Proteomics of Alveolar Macrophages
The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes…
- Trial name
- NCT00806091
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Lung Cancer
Gemcitabine and Cisplatin Before or After Surgery in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00398385
- Testing
- cisplatin, gemcitabine hydrochloride, adjuvant therapy
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- National Cancer Center, Korea
Autoimmune Pulmonary Alveolar Proteinosis
The Longitudinal Evaluation of Autoimmune Pulmonary Alveolar Proteinosis
The major goal of this study is to conduct a prospective, longitudinal study of autoimmune PAP to examine outcome measures for disease severity of potential use in clinical practice and/or clinical research studies.
- Trial name
- LongPAP (NCT03531996)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Coronary Artery Disease, Coronary Artery Bypass
Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres
The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Hypovolemia, Anesthesia, General
- Trial name
- PreDeARM (NCT02678559)
- Testing
- tee measurement, flotrac measurement, clearsight measurement
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
COPD
Comparing Pressure Based and Dilution Based Total Lung Capacity Measurements in COPD Patients for Lung Function Diagnostics
Total Lung Capacity (TLC) of the lungs can be determined using a pressure based method (i.e. by body plethysmography) or it can be determined using a dilution based method (i.e.
- Trial name
- NCT04531293
- Testing
- Respiratory Analysis System
- Where
- Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- ndd Medizintechnik AG
Acute Respiratory Distress Syndrome
Immune Alveolar Alterations During Pneumonia-Associated Acute Respiratory Distress Syndrome
Sepsis is a dysregulated host response to severe life-threatening infections, leading to organ failure and death in up to 40% of patients with septic shock.
- Trial name
- PICARD2 (NCT03971006)
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Acute Respiratory Distress Syndrome
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)
1. Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) 2. Research center: Single-center study. 3.
- Trial name
- NCT04552821
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tianjin Nankai Hospital
Pulmonary Alveolar Proteinosis(PAP)
The Study of Mesenchymal Stem Cells Treat Autoimmune Pulmonary Alveolar Proteinosis in Vitro
Autoimmune pulmonary alveolar proteinosis (aPAP) is a respiratory disease characterized by massive deposition of pulmonary surfactant in the alveoli, involving a variety of immune cells and factor disorders.
- Trial name
- NCT05640687
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to…
- Trial name
- NCT00281203
- Testing
- blood drawing, fiberoptic bronchoscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Lung Cancer
Diagnosis of Lung Cancer From Exhaled Breath With Silicon Biophotonic Device
The overall objective of this proposal is to develop a non-invasive, inexpensive and accurate device that detects VOCs in exhaled breath for lung cancer screening.
- Trial name
- NCT01660087
- Testing
- Biophotonic platform for VOC detection
- Where
- 2 sites in Singapore
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Pulmonary Alveolar Proteinosis
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis
This observational study was designed as a prospective epidemiological screening study. Patients who have applied to the centers participating in the study and who have previously been clinically or pathologically diagnosed with…
- Trial name
- NCT05300360
- Testing
- adenosine deaminase test
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- TRPHARM
Acute Respiratory Distress Syndrome (ARDS)
Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN)
Randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy of intravenous metoprolol in patients with Acute Respiratory Respiratory Distress Syndrome (ARDS).
- Trial name
- MAIDEN (NCT05847517)
- Testing
- Metoprolol Injection, saline 0.9%
- Where
- 12 sites in Spain
- Volunteers
- 14 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Pulmonary Alveolar Proteinosis, Bronchiectasis
Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects
This is a randomized, double-blind, placebo-controlled, single ascending (SAD), and multiple ascending dose (MAD) study conducted at a single clinical site within the UK.
- Conditions
- Pulmonary Alveolar Proteinosis, Bronchiectasis, Cystic Fibrosis, Acute Respiratory Distress Syndrome
- Trial name
- NCT02468908
- Testing
- Molgramostim
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Savara Inc.